3QF7

The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006302	biological_process	double-strand break repair
A	0016887	molecular_function	ATP hydrolysis activity
B	0006302	biological_process	double-strand break repair
B	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE ANP A 853

Chain	Residue
A	LEU12
A	SER38
A	ARG53
A	TYR54
A	ASP59
A	VAL61
A	ASN62
A	ARG63
A	GLN142
A	GLU798
A	MG854
A	GLY13
A	HOH863
A	HOH864
A	HOH874
A	HOH931
B	ARG741
B	ARG762
B	GLY766
B	SER768
B	GLY769
B	GLY770
A	PRO31
B	GLU771
A	ASN32
A	GLY33
A	ALA34
A	GLY35
A	LYS36
A	SER37

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 854

Chain	Residue
A	SER37
A	GLN142
A	ANP853
A	HOH863
A	HOH876

---

site_id	AC3
Number of Residues	29
Details	BINDING SITE FOR RESIDUE ANP B 853

Chain	Residue
A	ARG741
A	ARG762
A	GLY766
A	SER768
A	GLY769
A	GLY770
A	GLU771
A	HOH882
B	LEU12
B	GLY13
B	PRO31
B	ASN32
B	GLY33
B	ALA34
B	GLY35
B	LYS36
B	SER37
B	SER38
B	ARG53
B	TYR54
B	ASP59
B	VAL61
B	ASN62
B	ARG63
B	GLN142
B	GLU798
B	MG854
B	HOH855
B	HOH881

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 854

Chain	Residue
B	SER37
B	GLN142
B	ANP853
B	HOH855
B	HOH856

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGERALISISLAM

Chain	Residue	Details
A	LEU767-MET781

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25349191","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21458667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"4W9M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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