3QD6

Crystal structure of the CD40 and CD154 (CD40L) complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
D	0005164	molecular_function	tumor necrosis factor receptor binding
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
E	0005164	molecular_function	tumor necrosis factor receptor binding
E	0006955	biological_process	immune response
E	0016020	cellular_component	membrane
F	0005164	molecular_function	tumor necrosis factor receptor binding
F	0006955	biological_process	immune response
F	0016020	cellular_component	membrane
R	0009897	cellular_component	external side of plasma membrane
R	0038023	molecular_function	signaling receptor activity
R	0042113	biological_process	B cell activation
R	0050776	biological_process	regulation of immune response
S	0009897	cellular_component	external side of plasma membrane
S	0038023	molecular_function	signaling receptor activity
S	0042113	biological_process	B cell activation
S	0050776	biological_process	regulation of immune response
T	0009897	cellular_component	external side of plasma membrane
T	0038023	molecular_function	signaling receptor activity
T	0042113	biological_process	B cell activation
T	0050776	biological_process	regulation of immune response
U	0009897	cellular_component	external side of plasma membrane
U	0038023	molecular_function	signaling receptor activity
U	0042113	biological_process	B cell activation
U	0050776	biological_process	regulation of immune response

Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LtVKrQGLYYIyaQVtF

Chain	Residue	Details
A	LEU161-PHE177

---

site_id	PS00652
Number of Residues	34
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Crekq..Ylinsq.....C..Csl.Cqpgqklvsd..Cteft..ETEC

Chain	Residue	Details
R	CYS26-CYS59

---

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtCeeGWhctsea..C

Chain	Residue	Details
R	CYS103-CYS116

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"11676606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	168
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	70
Details	Repeat: {"description":"TNFR-Cys 1"}

Chain

Residue

Details

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