3Q8K

Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+, and K+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0004518	molecular_function	nuclease activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SM A 1001

Chain	Residue
A	ASP86
A	GLU160
A	HOH598
A	HOH693
A	HOH742
E	DT2

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SM A 1002

Chain	Residue
A	OH347
A	HOH555
E	DT2
A	GLU160
A	ASP179
A	ASP181

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SM A 1003

Chain	Residue
A	GLU57
A	GLU285
A	GLU313
A	GLN342
A	HOH767
A	HOH768
A	HOH769

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SM A 1004

Chain	Residue
A	GLU57
A	GLU59
A	GLU313
A	GLN342
A	HOH764
A	HOH765
A	HOH766

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1101

Chain	Residue
A	SER237
A	ILE238
A	ILE241
A	HOH627
D	DT5
D	HOH628

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE OH A 347

Chain	Residue
A	GLY2
A	ASP179
A	ASP181
A	ASP233
A	HOH555
A	SM1002
E	DT2
E	HOH455

---

Functional Information from PROSITE/UniProt

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPvYVFDGkpPqLK

Chain	Residue	Details
A	ILE79-LYS93

---

site_id	PS00842
Number of Residues	15
Details	XPG_2 XPG protein signature 2. GIPYLdAPsEAEASC

Chain	Residue	Details
A	GLY149-CYS163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	131
Details	Region: {"description":"I-domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK2","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---