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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3Q3F

Engineering Domain-Swapped Binding Interfaces by Mutually Exclusive Folding: Insertion of Ubiquitin into position 103 of Barnase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004521	molecular_function	RNA endonuclease activity
A	0004540	molecular_function	RNA nuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 189

Chain	Residue
A	ALA1
A	GLN2
A	VAL3
A	ARG146
A	ARG176
A	LEU177
A	ARG178
A	HOH235
A	HOH298

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 190

Chain	Residue
A	LYS62
A	ASN77
A	THR79
A	GLY181
A	HOH276
A	HOH291
A	HOH326
A	HOH365
A	HOH420

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 191

Chain	Residue
A	ARG146
A	GLN153
A	ARG176
A	HOH256
A	HOH313
A	HOH395
A	HOH402

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 192

Chain	Residue
A	SER57
A	ARG59
A	THR118
A	LEU119
A	GLU120
A	LYS137
A	HOH308
A	HOH429

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 193

Chain	Residue
A	LYS27
A	GLU73
A	ARG83
A	ARG87
A	HIS102
A	GLY105
A	GLU120
A	HOH397
A	HOH424
A	HOH450

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A 194

Chain	Residue
A	TRP35
A	ALA37
A	SER38
A	LYS39
A	GLY40
A	PHE82
A	ARG83
A	LYS167
A	HOH250
A	HOH268
A	HOH335

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 195

Chain	Residue
A	ARG72
A	SER92
A	HOH356
A	HOH421

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 196

Chain	Residue
A	ARG72
A	HOH387

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 197

Chain	Residue
A	THR6
A	PHE7
A	ASP8
A	ASN77
A	HOH378
A	HOH415
A	HOH422
A	HOH425

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 198

Chain	Residue
A	HIS18
A	TRP94
A	ALA150
A	HOH227

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 199

Chain	Residue
A	ARG59
A	HOH249
A	HOH380

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 200

Chain	Residue
A	THR113
A	LYS115
A	HOH389

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	GLU155
A	ARG158
A	HOH245
A	HOH325

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	LYS152
A	GLN153

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	PHE149
A	SER169
A	THR170
A	HOH255
A	HOH261
A	HOH340

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 204

Chain	Residue
A	GLY65
A	ARG69
A	HOH210
A	HOH229
A	HOH231

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS131-ASP156

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	GLU73

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	HIS102

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
A	ARG158
A	ARG176

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Essential for function

Chain	Residue	Details
A	HIS172

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291

Chain	Residue	Details
A	SER169

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269\|PubMed:32330457

Chain	Residue	Details
A	THR170

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269\|PubMed:28525742

Chain	Residue	Details
A	GLY180

site_id	SWS_FT_FI8
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603

Chain	Residue	Details
A	LYS110

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY180

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603, ECO:0000269\|PubMed:16543144

Chain	Residue	Details
A	LYS115
A	LYS152

site_id	SWS_FT_FI11
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:15466860

Chain	Residue	Details
A	LYS131

site_id	SWS_FT_FI12
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:25752573, ECO:0000269\|PubMed:25752577, ECO:0000269\|PubMed:34239127

Chain	Residue	Details
A	LYS133

site_id	SWS_FT_FI13
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:25752577

Chain	Residue	Details
A	LYS137

site_id	SWS_FT_FI14
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:18719106

Chain	Residue	Details
A	LYS167

218853

PDB entries from 2024-04-24

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