3PZE

JNK1 in complex with inhibitor

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Functional Information from GO Data

ChainGOidnamespacecontents
A0030424cellular_componentaxon
A0097441cellular_componentbasal dendrite
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005739cellular_componentmitochondrion
A0043005cellular_componentneuron projection
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0005524molecular_functionATP binding
A0019899molecular_functionenzyme binding
A0042826molecular_functionhistone deacetylase binding
A0035033molecular_functionhistone deacetylase regulator activity
A0004705molecular_functionJUN kinase activity
A0016301molecular_functionkinase activity
A0004707molecular_functionMAP kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0034198biological_processcellular response to amino acid starvation
A0071276biological_processcellular response to cadmium ion
A0071345biological_processcellular response to cytokine stimulus
A0071222biological_processcellular response to lipopolysaccharide
A0071260biological_processcellular response to mechanical stimulus
A0071310biological_processcellular response to organic substance
A0034614biological_processcellular response to reactive oxygen species
A0038095biological_processFc-epsilon receptor signaling pathway
A0035556biological_processintracellular signal transduction
A0007254biological_processJNK cascade
A0007258biological_processJUN phosphorylation
A0043066biological_processnegative regulation of apoptotic process
A0032091biological_processnegative regulation of protein binding
A0048666biological_processneuron development
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0043065biological_processpositive regulation of apoptotic process
A0031281biological_processpositive regulation of cyclase activity
A0090045biological_processpositive regulation of deacetylase activity
A0010628biological_processpositive regulation of gene expression
A1900740biological_processpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
A0051247biological_processpositive regulation of protein metabolic process
A0006468biological_processprotein phosphorylation
A0042752biological_processregulation of circadian rhythm
A1902595biological_processregulation of DNA replication origin binding
A0051090biological_processregulation of DNA-binding transcription factor activity
A0010468biological_processregulation of gene expression
A0016241biological_processregulation of macroautophagy
A0032880biological_processregulation of protein localization
A0009612biological_processresponse to mechanical stimulus
A0009411biological_processresponse to UV
A0048511biological_processrhythmic process
A0051403biological_processstress-activated MAPK cascade
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15BINDING SITE FOR RESIDUE SO4 A 402
ChainResidue
AGLY35
AALA36
AARG69
ALYS153
AHOH423

AC24BINDING SITE FOR RESIDUE SO4 A 403
ChainResidue
AARG25
ALEU48
ALYS288
AHOH390

AC38BINDING SITE FOR RESIDUE SO4 A 404
ChainResidue
APRO244
ACYS245
AVAL303
AILE304
AASP305
AHOH368
AHOH393
AHOH429

AC44BINDING SITE FOR RESIDUE SO4 A 405
ChainResidue
ATHR188
AARG189
AARG192
ATYR230

AC510BINDING SITE FOR RESIDUE CFK A 1
ChainResidue
AILE32
ASER34
AVAL40
AALA53
AGLU109
ALEU110
AMET111
AASP112
AALA113
ALEU168

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
CFK_3pze_A_1193-(carbamoylamino)-5-phenylthiophene-2-carboxamide binding site
ChainResidueligand
AILE32-GLY35CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
AGLY38CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
AVAL40CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
AALA53CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
ALYS55CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
AILE86CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
AMET108-ASN114CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
AGLN117CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
AVAL158CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide
ALEU168CFK: 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS01351103
ChainResidueDetails
APHE61-CYS163

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Proton acceptor. {ECO:0000255|PROSITE- ProRule:PRU00159, ECO:0000255|PROSITE- ProRule:PRU10027}.
ChainResidueDetails
AASP145

SWS_FT_FI21ATP. {ECO:0000255|PROSITE- ProRule:PRU00159}.
ChainResidueDetails
ALYS49

SWS_FT_FI39ATP. {ECO:0000255|PROSITE- ProRule:PRU00159}.
ChainResidueDetails
AILE26-VAL34

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Catalytic Information from CSA

site_idNumber of ResiduesDetails