3PX4
Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (wobble) in Ajar Conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0006260 | biological_process | DNA replication |
| D | 0006261 | biological_process | DNA-templated DNA replication |
| D | 0008408 | molecular_function | 3'-5' exonuclease activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DCT A 203 |
| Chain | Residue |
| A | GLU469 |
| A | GLN470 |
| A | ASP471 |
| A | ARG472 |
| A | LEU473 |
| A | LEU767 |
| A | HIS768 |
| A | HOH918 |
| A | HOH1365 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE DCT D 202 |
| Chain | Residue |
| D | MG1 |
| D | HOH84 |
| D | ARG615 |
| D | TYR654 |
| D | GLN656 |
| D | GLU658 |
| D | HIS682 |
| D | ARG702 |
| D | LYS706 |
| D | TYR710 |
| D | ASP830 |
| D | HOH891 |
| D | HOH1143 |
| D | HOH1373 |
| D | HOH1454 |
| E | DOC29 |
| E | HOH101 |
| F | DA3 |
| F | DG4 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 1 |
| Chain | Residue |
| D | DCT202 |
| D | ASP653 |
| D | TYR654 |
| D | ASP830 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 877 |
| Chain | Residue |
| D | MET299 |
| D | ALA300 |
| D | ARG343 |
| D | ARG677 |
| D | HOH1432 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2 |
| Chain | Residue |
| A | ARG779 |
| A | ASN780 |
| D | ARG423 |
| D | PRO424 |
| D | HOH1175 |
Functional Information from PROSITE/UniProt
| site_id | PS00447 |
| Number of Residues | 20 |
| Details | DNA_POLYMERASE_A DNA polymerase family A signature. RrqAKavnYGivYgiSdygL |
| Chain | Residue | Details |
| A | ARG702-LEU721 |
