3PTA

Crystal structure of human DNMT1(646-1600) in complex with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0008168	molecular_function	methyltransferase activity
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH A 1601

Chain	Residue
A	PHE1145
A	CYS1191
A	PRO1225
A	LEU1247
A	GLU1266
A	ASN1578
A	ALA1579
A	VAL1580
A	SER1146
A	GLY1147
A	GLY1150
A	LEU1151
A	GLU1168
A	MET1169
A	TRP1170
A	GLU1189

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS1476
A	CYS1478
A	CYS1485
A	HIS1502

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS653
A	CYS656
A	CYS659
A	CYS691

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	HIS793
A	CYS820
A	CYS893
A	CYS896

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 5

Chain	Residue
A	CYS664
A	CYS667
A	CYS670
A	CYS686
A	GLN687

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS

Chain	Residue	Details
A	GLU1218-SER1230

---

site_id	PS00095
Number of Residues	19
Details	C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI

Chain	Residue	Details
A	ARG1574-ILE1592

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	ZN_FING: CXXC-type => ECO:0000255|PROSITE-ProRule:PRU00509

Chain	Residue	Details
A	ASN646-PRO692

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE:

Chain	Residue	Details
A	CYS1226

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00509

Chain	Residue	Details
A	CYS653
A	CYS656
A	CYS659
A	CYS664
A	CYS667
A	CYS670
A	CYS686
A	CYS691

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P13864

Chain	Residue	Details
A	SER1146
A	GLY1150
A	ASP1190
A	VAL1580

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PTA

Chain	Residue	Details
A	GLU1168
A	CYS1191
A	ASN1578

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER714

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336

Chain	Residue	Details
A	SER732

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21947282

Chain	Residue	Details
A	LYS749
A	LYS891
A	LYS957
A	LYS961
A	LYS975
A	LYS1054
A	LYS1349
A	LYS1415

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER878

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21947282, ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1111
A	LYS1113
A	LYS1115

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by EHMT2 => ECO:0000269|PubMed:21947282

Chain	Residue	Details
A	LYS1117

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P13864

Chain	Residue	Details
A	LYS1119
A	LYS1121

---