3PT6

Crystal structure of mouse DNMT1(650-1602) in complex with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0008168	molecular_function	methyltransferase activity
A	0008270	molecular_function	zinc ion binding
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0008168	molecular_function	methyltransferase activity
B	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS1479
A	CYS1481
A	CYS1487
A	HIS1504

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS656
A	CYS659
A	CYS662
A	CYS694

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	CYS823
A	CYS897
A	CYS900
A	HIS796

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 4

Chain	Residue
A	CYS667
A	CYS670
A	CYS673
A	CYS689

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	HIS796
B	CYS823
B	CYS897
B	CYS900

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS656
B	CYS659
B	CYS662
B	CYS694

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 3

Chain	Residue
B	CYS1479
B	CYS1481
B	CYS1487
B	HIS1504

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 4

Chain	Residue
B	CYS667
B	CYS670
B	CYS673
B	CYS689

---

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH A 1603

Chain	Residue
A	HOH5
A	HOH13
A	PHE1148
A	SER1149
A	GLY1152
A	GLY1153
A	LEU1154
A	GLU1171
A	MET1172
A	TRP1173
A	GLU1192
A	ASP1193
A	GLY1226
A	ASN1580
A	ALA1581
A	VAL1582

---

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH B 1603

Chain	Residue
B	HOH5
B	PHE1148
B	SER1149
B	GLY1150
B	GLY1152
B	GLY1153
B	LEU1154
B	GLU1171
B	MET1172
B	TRP1173
B	ASP1193
B	CYS1194
B	GLY1226
B	ALA1581
B	VAL1582

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS

Chain	Residue	Details
A	GLU1221-SER1233

---

site_id	PS00095
Number of Residues	19
Details	C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI

Chain	Residue	Details
A	ARG1576-ILE1594

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:17576694

Chain	Residue	Details
A	CYS1229
B	CYS1229

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00509

Chain	Residue	Details
A	CYS656
B	CYS659
B	CYS662
B	CYS667
B	CYS670
B	CYS673
B	CYS689
B	CYS694
A	CYS659
A	CYS662
A	CYS667
A	CYS670
A	CYS673
A	CYS689
A	CYS694
B	CYS656

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:4DA4

Chain	Residue	Details
A	SER1149
B	SER1149

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9, ECO:0007744|PDB:4DA4

Chain	Residue	Details
A	GLY1153
A	GLU1171
A	VAL1582
B	GLY1153
B	GLU1171
B	VAL1582

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9

Chain	Residue	Details
A	ASP1193
B	ASP1193

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER713
B	SER713

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER717
B	SER717

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P26358

Chain	Residue	Details
A	SER735
A	SER882
B	SER735
B	SER882

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P26358

Chain	Residue	Details
A	LYS752
A	LYS1352
A	LYS1418
B	LYS752
B	LYS895
B	LYS961
B	LYS965
B	LYS979
B	LYS1114
B	LYS1116
B	LYS1118
A	LYS895
B	LYS1120
B	LYS1352
B	LYS1418
A	LYS961
A	LYS965
A	LYS979
A	LYS1114
A	LYS1116
A	LYS1118
A	LYS1120

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS1122
A	LYS1124
B	LYS1122
B	LYS1124

---