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3PSL

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000123cellular_componenthistone acetyltransferase complex
A0001501biological_processskeletal system development
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0006094biological_processgluconeogenesis
A0006325biological_processchromatin organization
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0035097cellular_componenthistone methyltransferase complex
A0042393molecular_functionhistone binding
A0042800molecular_functionhistone H3K4 methyltransferase activity
A0044545cellular_componentNSL complex
A0044665cellular_componentMLL1/2 complex
A0044666cellular_componentMLL3/4 complex
A0045722biological_processpositive regulation of gluconeogenesis
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0045893biological_processpositive regulation of DNA-templated transcription
A0045995biological_processregulation of embryonic development
A0048188cellular_componentSet1C/COMPASS complex
A0051302biological_processregulation of cell division
A0051726biological_processregulation of cell cycle
A0071339cellular_componentMLL1 complex
A0072686cellular_componentmitotic spindle
A0140004molecular_functionhistone H3Q5ser reader activity
A0140109molecular_functionhistone H3K4me1 reader activity
A0140672cellular_componentATAC complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000123cellular_componenthistone acetyltransferase complex
B0001501biological_processskeletal system development
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0006094biological_processgluconeogenesis
B0006325biological_processchromatin organization
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0035097cellular_componenthistone methyltransferase complex
B0042393molecular_functionhistone binding
B0042800molecular_functionhistone H3K4 methyltransferase activity
B0044545cellular_componentNSL complex
B0044665cellular_componentMLL1/2 complex
B0044666cellular_componentMLL3/4 complex
B0045722biological_processpositive regulation of gluconeogenesis
B0045815biological_processtranscription initiation-coupled chromatin remodeling
B0045893biological_processpositive regulation of DNA-templated transcription
B0045995biological_processregulation of embryonic development
B0048188cellular_componentSet1C/COMPASS complex
B0051302biological_processregulation of cell division
B0051726biological_processregulation of cell cycle
B0071339cellular_componentMLL1 complex
B0072686cellular_componentmitotic spindle
B0140004molecular_functionhistone H3Q5ser reader activity
B0140109molecular_functionhistone H3K4me1 reader activity
B0140672cellular_componentATAC complex
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR CHAIN C OF N-ALPHA ACETYLATED FORM OF HISTONE H3
ChainResidue
AHOH13
APHE133
ACYS261
APHE263
AGLU322
AHOH368
BHOH407
CHOH11
CHOH74
CHOH157
AALA47
AVAL48
ASER49
AGLY89
AILE90
ASER91
AASP107
ATYR131

site_idAC2
Number of Residues22
DetailsBINDING SITE FOR CHAIN D OF N-ALPHA ACETYLATED FORM OF HISTONE H3
ChainResidue
AGLU151
AHIS170
BHOH9
BALA47
BSER49
BGLY89
BILE90
BSER91
BASP107
BTYR131
BPHE133
BTYR260
BCYS261
BPHE263
BHOH336
BHOH349
BHOH363
BHOH454
DHOH12
DHOH64
DHOH68
DHOH479

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
ChainResidueDetails
ALEU102-VAL116
AILE144-VAL158
AILE186-THR200
AILE274-LEU288

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsSITE: Important for interaction with histone H3
ChainResidueDetails
AASP107
APHE133
APHE263
AGLU322
BASP107
BPHE133
BPHE263
BGLU322

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS112
BLYS112

site_idSWS_FT_FI3
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS27
ALYS46
BLYS27
BLYS46

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PDB entries from 2025-06-18

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