3PGW

Crystal structure of human U1 snRNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005685	cellular_component	U1 snRNP
A	0030619	molecular_function	U1 snRNA binding
A	0042802	molecular_function	identical protein binding
A	0071011	cellular_component	precatalytic spliceosome
A	0097525	cellular_component	spliceosomal snRNP complex
A	1990446	molecular_function	U1 snRNP binding
B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
B	0000245	biological_process	spliceosomal complex assembly
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0005683	cellular_component	U7 snRNP
B	0005684	cellular_component	U2-type spliceosomal complex
B	0005685	cellular_component	U1 snRNP
B	0005686	cellular_component	U2 snRNP
B	0005687	cellular_component	U4 snRNP
B	0005689	cellular_component	U12-type spliceosomal complex
B	0005690	cellular_component	U4atac snRNP
B	0005697	cellular_component	telomerase holoenzyme complex
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006479	biological_process	protein methylation
B	0008380	biological_process	RNA splicing
B	0030532	cellular_component	small nuclear ribonucleoprotein complex
B	0034693	cellular_component	U11/U12 snRNP
B	0034709	cellular_component	methylosome
B	0034719	cellular_component	SMN-Sm protein complex
B	0036261	biological_process	7-methylguanosine cap hypermethylation
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
B	0070034	molecular_function	telomerase RNA binding
B	0070990	molecular_function	snRNP binding
B	0071001	cellular_component	U4/U6 snRNP
B	0071002	cellular_component	U4atac/U6atac snRNP
B	0071004	cellular_component	U2-type prespliceosome
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071006	cellular_component	U2-type catalytic step 1 spliceosome
B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
B	0071011	cellular_component	precatalytic spliceosome
B	0071013	cellular_component	catalytic step 2 spliceosome
B	0071014	cellular_component	post-mRNA release spliceosomal complex
B	0071016	cellular_component	U12-type precatalytic spliceosome
B	0071018	cellular_component	U12-type catalytic step 2 spliceosome
B	0071020	cellular_component	post-spliceosomal complex
B	0071045	biological_process	nuclear histone mRNA catabolic process
B	0071204	cellular_component	histone pre-mRNA 3'end processing complex
B	0071208	molecular_function	histone pre-mRNA DCP binding
B	1903241	biological_process	U2-type prespliceosome assembly
B	1990446	molecular_function	U1 snRNP binding
B	1990447	molecular_function	U2 snRNP binding
E	0000244	biological_process	spliceosomal tri-snRNP complex assembly
E	0000245	biological_process	spliceosomal complex assembly
E	0000387	biological_process	spliceosomal snRNP assembly
E	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0005683	cellular_component	U7 snRNP
E	0005684	cellular_component	U2-type spliceosomal complex
E	0005685	cellular_component	U1 snRNP
E	0005686	cellular_component	U2 snRNP
E	0005687	cellular_component	U4 snRNP
E	0005689	cellular_component	U12-type spliceosomal complex
E	0005690	cellular_component	U4atac snRNP
E	0005697	cellular_component	telomerase holoenzyme complex
E	0005829	cellular_component	cytosol
E	0030532	cellular_component	small nuclear ribonucleoprotein complex
E	0034693	cellular_component	U11/U12 snRNP
E	0034709	cellular_component	methylosome
E	0034715	cellular_component	pICln-Sm protein complex
E	0034719	cellular_component	SMN-Sm protein complex
E	0036261	biological_process	7-methylguanosine cap hypermethylation
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
E	0071001	cellular_component	U4/U6 snRNP
E	0071002	cellular_component	U4atac/U6atac snRNP
E	0071005	cellular_component	U2-type precatalytic spliceosome
E	0071006	cellular_component	U2-type catalytic step 1 spliceosome
E	0071007	cellular_component	U2-type catalytic step 2 spliceosome
E	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
E	0071011	cellular_component	precatalytic spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
E	0071014	cellular_component	post-mRNA release spliceosomal complex
E	0071016	cellular_component	U12-type precatalytic spliceosome
E	0071018	cellular_component	U12-type catalytic step 2 spliceosome
E	0071020	cellular_component	post-spliceosomal complex
E	0071045	biological_process	nuclear histone mRNA catabolic process
E	1903241	biological_process	U2-type prespliceosome assembly
F	0000244	biological_process	spliceosomal tri-snRNP complex assembly
F	0000245	biological_process	spliceosomal complex assembly
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005682	cellular_component	U5 snRNP
F	0005683	cellular_component	U7 snRNP
F	0005684	cellular_component	U2-type spliceosomal complex
F	0005685	cellular_component	U1 snRNP
F	0005686	cellular_component	U2 snRNP
F	0005687	cellular_component	U4 snRNP
F	0005689	cellular_component	U12-type spliceosomal complex
F	0005690	cellular_component	U4atac snRNP
F	0005829	cellular_component	cytosol
F	0008380	biological_process	RNA splicing
F	0022618	biological_process	protein-RNA complex assembly
F	0030532	cellular_component	small nuclear ribonucleoprotein complex
F	0034693	cellular_component	U11/U12 snRNP
F	0034709	cellular_component	methylosome
F	0034715	cellular_component	pICln-Sm protein complex
F	0034719	cellular_component	SMN-Sm protein complex
F	0036261	biological_process	7-methylguanosine cap hypermethylation
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
F	0071001	cellular_component	U4/U6 snRNP
F	0071002	cellular_component	U4atac/U6atac snRNP
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0071006	cellular_component	U2-type catalytic step 1 spliceosome
F	0071007	cellular_component	U2-type catalytic step 2 spliceosome
F	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
F	0071011	cellular_component	precatalytic spliceosome
F	0071013	cellular_component	catalytic step 2 spliceosome
F	0071014	cellular_component	post-mRNA release spliceosomal complex
F	0071016	cellular_component	U12-type precatalytic spliceosome
F	0071018	cellular_component	U12-type catalytic step 2 spliceosome
F	0071020	cellular_component	post-spliceosomal complex
F	0071045	biological_process	nuclear histone mRNA catabolic process
F	1903241	biological_process	U2-type prespliceosome assembly
G	0000244	biological_process	spliceosomal tri-snRNP complex assembly
G	0000245	biological_process	spliceosomal complex assembly
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005682	cellular_component	U5 snRNP
G	0005683	cellular_component	U7 snRNP
G	0005684	cellular_component	U2-type spliceosomal complex
G	0005685	cellular_component	U1 snRNP
G	0005686	cellular_component	U2 snRNP
G	0005687	cellular_component	U4 snRNP
G	0005689	cellular_component	U12-type spliceosomal complex
G	0005690	cellular_component	U4atac snRNP
G	0005829	cellular_component	cytosol
G	0008380	biological_process	RNA splicing
G	0030532	cellular_component	small nuclear ribonucleoprotein complex
G	0034693	cellular_component	U11/U12 snRNP
G	0034709	cellular_component	methylosome
G	0034719	cellular_component	SMN-Sm protein complex
G	0036261	biological_process	7-methylguanosine cap hypermethylation
G	0043186	cellular_component	P granule
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
G	0071001	cellular_component	U4/U6 snRNP
G	0071002	cellular_component	U4atac/U6atac snRNP
G	0071004	cellular_component	U2-type prespliceosome
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0071006	cellular_component	U2-type catalytic step 1 spliceosome
G	0071007	cellular_component	U2-type catalytic step 2 spliceosome
G	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
G	0071011	cellular_component	precatalytic spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
G	0071014	cellular_component	post-mRNA release spliceosomal complex
G	0071016	cellular_component	U12-type precatalytic spliceosome
G	0071018	cellular_component	U12-type catalytic step 2 spliceosome
G	0071020	cellular_component	post-spliceosomal complex
G	0071045	biological_process	nuclear histone mRNA catabolic process
G	0097526	cellular_component	spliceosomal tri-snRNP complex
G	1903241	biological_process	U2-type prespliceosome assembly
H	0000244	biological_process	spliceosomal tri-snRNP complex assembly
H	0000245	biological_process	spliceosomal complex assembly
H	0000387	biological_process	spliceosomal snRNP assembly
H	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005682	cellular_component	U5 snRNP
H	0005683	cellular_component	U7 snRNP
H	0005684	cellular_component	U2-type spliceosomal complex
H	0005685	cellular_component	U1 snRNP
H	0005686	cellular_component	U2 snRNP
H	0005687	cellular_component	U4 snRNP
H	0005689	cellular_component	U12-type spliceosomal complex
H	0005690	cellular_component	U4atac snRNP
H	0005697	cellular_component	telomerase holoenzyme complex
H	0005829	cellular_component	cytosol
H	0030532	cellular_component	small nuclear ribonucleoprotein complex
H	0034693	cellular_component	U11/U12 snRNP
H	0034709	cellular_component	methylosome
H	0034715	cellular_component	pICln-Sm protein complex
H	0034719	cellular_component	SMN-Sm protein complex
H	0036261	biological_process	7-methylguanosine cap hypermethylation
H	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
H	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
H	0071001	cellular_component	U4/U6 snRNP
H	0071002	cellular_component	U4atac/U6atac snRNP
H	0071005	cellular_component	U2-type precatalytic spliceosome
H	0071006	cellular_component	U2-type catalytic step 1 spliceosome
H	0071007	cellular_component	U2-type catalytic step 2 spliceosome
H	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
H	0071011	cellular_component	precatalytic spliceosome
H	0071013	cellular_component	catalytic step 2 spliceosome
H	0071014	cellular_component	post-mRNA release spliceosomal complex
H	0071016	cellular_component	U12-type precatalytic spliceosome
H	0071018	cellular_component	U12-type catalytic step 2 spliceosome
H	0071020	cellular_component	post-spliceosomal complex
H	0071045	biological_process	nuclear histone mRNA catabolic process
H	1903241	biological_process	U2-type prespliceosome assembly
I	0000244	biological_process	spliceosomal tri-snRNP complex assembly
I	0000245	biological_process	spliceosomal complex assembly
I	0000387	biological_process	spliceosomal snRNP assembly
I	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0005682	cellular_component	U5 snRNP
I	0005683	cellular_component	U7 snRNP
I	0005684	cellular_component	U2-type spliceosomal complex
I	0005685	cellular_component	U1 snRNP
I	0005686	cellular_component	U2 snRNP
I	0005687	cellular_component	U4 snRNP
I	0005689	cellular_component	U12-type spliceosomal complex
I	0005690	cellular_component	U4atac snRNP
I	0005829	cellular_component	cytosol
I	0008380	biological_process	RNA splicing
I	0022618	biological_process	protein-RNA complex assembly
I	0030532	cellular_component	small nuclear ribonucleoprotein complex
I	0034693	cellular_component	U11/U12 snRNP
I	0034709	cellular_component	methylosome
I	0034715	cellular_component	pICln-Sm protein complex
I	0034719	cellular_component	SMN-Sm protein complex
I	0036261	biological_process	7-methylguanosine cap hypermethylation
I	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
I	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
I	0071001	cellular_component	U4/U6 snRNP
I	0071002	cellular_component	U4atac/U6atac snRNP
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071006	cellular_component	U2-type catalytic step 1 spliceosome
I	0071007	cellular_component	U2-type catalytic step 2 spliceosome
I	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
I	0071011	cellular_component	precatalytic spliceosome
I	0071013	cellular_component	catalytic step 2 spliceosome
I	0071014	cellular_component	post-mRNA release spliceosomal complex
I	0071016	cellular_component	U12-type precatalytic spliceosome
I	0071018	cellular_component	U12-type catalytic step 2 spliceosome
I	0071020	cellular_component	post-spliceosomal complex
I	0071045	biological_process	nuclear histone mRNA catabolic process
I	1903241	biological_process	U2-type prespliceosome assembly
J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
J	0000245	biological_process	spliceosomal complex assembly
J	0000387	biological_process	spliceosomal snRNP assembly
J	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0005682	cellular_component	U5 snRNP
J	0005683	cellular_component	U7 snRNP
J	0005684	cellular_component	U2-type spliceosomal complex
J	0005685	cellular_component	U1 snRNP
J	0005686	cellular_component	U2 snRNP
J	0005687	cellular_component	U4 snRNP
J	0005689	cellular_component	U12-type spliceosomal complex
J	0005690	cellular_component	U4atac snRNP
J	0005829	cellular_component	cytosol
J	0008380	biological_process	RNA splicing
J	0030532	cellular_component	small nuclear ribonucleoprotein complex
J	0034693	cellular_component	U11/U12 snRNP
J	0034709	cellular_component	methylosome
J	0034719	cellular_component	SMN-Sm protein complex
J	0036261	biological_process	7-methylguanosine cap hypermethylation
J	0043186	cellular_component	P granule
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
J	0071001	cellular_component	U4/U6 snRNP
J	0071002	cellular_component	U4atac/U6atac snRNP
J	0071004	cellular_component	U2-type prespliceosome
J	0071005	cellular_component	U2-type precatalytic spliceosome
J	0071006	cellular_component	U2-type catalytic step 1 spliceosome
J	0071007	cellular_component	U2-type catalytic step 2 spliceosome
J	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
J	0071011	cellular_component	precatalytic spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
J	0071014	cellular_component	post-mRNA release spliceosomal complex
J	0071016	cellular_component	U12-type precatalytic spliceosome
J	0071018	cellular_component	U12-type catalytic step 2 spliceosome
J	0071020	cellular_component	post-spliceosomal complex
J	0071045	biological_process	nuclear histone mRNA catabolic process
J	0097526	cellular_component	spliceosomal tri-snRNP complex
J	1903241	biological_process	U2-type prespliceosome assembly
L	0000387	biological_process	spliceosomal snRNP assembly
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
L	0003729	molecular_function	mRNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005685	cellular_component	U1 snRNP
L	0016607	cellular_component	nuclear speck
L	0030619	molecular_function	U1 snRNA binding
L	0043202	cellular_component	lysosomal lumen
L	0043484	biological_process	regulation of RNA splicing
L	0061084	biological_process	negative regulation of protein refolding
L	0071004	cellular_component	U2-type prespliceosome
L	0071011	cellular_component	precatalytic spliceosome
L	0071300	biological_process	cellular response to retinoic acid
L	0071356	biological_process	cellular response to tumor necrosis factor
L	0071560	biological_process	cellular response to transforming growth factor beta stimulus
L	1904715	biological_process	negative regulation of chaperone-mediated autophagy
L	1990446	molecular_function	U1 snRNP binding
P	0000387	biological_process	spliceosomal snRNP assembly
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003676	molecular_function	nucleic acid binding
P	0003677	molecular_function	DNA binding
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005685	cellular_component	U1 snRNP
P	0030619	molecular_function	U1 snRNA binding
P	0042802	molecular_function	identical protein binding
P	0071011	cellular_component	precatalytic spliceosome
P	0097525	cellular_component	spliceosomal snRNP complex
P	1990446	molecular_function	U1 snRNP binding
Q	0000244	biological_process	spliceosomal tri-snRNP complex assembly
Q	0000245	biological_process	spliceosomal complex assembly
Q	0000387	biological_process	spliceosomal snRNP assembly
Q	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0005682	cellular_component	U5 snRNP
Q	0005683	cellular_component	U7 snRNP
Q	0005684	cellular_component	U2-type spliceosomal complex
Q	0005685	cellular_component	U1 snRNP
Q	0005686	cellular_component	U2 snRNP
Q	0005687	cellular_component	U4 snRNP
Q	0005689	cellular_component	U12-type spliceosomal complex
Q	0005690	cellular_component	U4atac snRNP
Q	0005697	cellular_component	telomerase holoenzyme complex
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006479	biological_process	protein methylation
Q	0008380	biological_process	RNA splicing
Q	0030532	cellular_component	small nuclear ribonucleoprotein complex
Q	0034693	cellular_component	U11/U12 snRNP
Q	0034709	cellular_component	methylosome
Q	0034719	cellular_component	SMN-Sm protein complex
Q	0036261	biological_process	7-methylguanosine cap hypermethylation
Q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Q	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
Q	0070034	molecular_function	telomerase RNA binding
Q	0070990	molecular_function	snRNP binding
Q	0071001	cellular_component	U4/U6 snRNP
Q	0071002	cellular_component	U4atac/U6atac snRNP
Q	0071004	cellular_component	U2-type prespliceosome
Q	0071005	cellular_component	U2-type precatalytic spliceosome
Q	0071006	cellular_component	U2-type catalytic step 1 spliceosome
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
Q	0071011	cellular_component	precatalytic spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
Q	0071014	cellular_component	post-mRNA release spliceosomal complex
Q	0071016	cellular_component	U12-type precatalytic spliceosome
Q	0071018	cellular_component	U12-type catalytic step 2 spliceosome
Q	0071020	cellular_component	post-spliceosomal complex
Q	0071045	biological_process	nuclear histone mRNA catabolic process
Q	0071204	cellular_component	histone pre-mRNA 3'end processing complex
Q	0071208	molecular_function	histone pre-mRNA DCP binding
Q	1903241	biological_process	U2-type prespliceosome assembly
Q	1990446	molecular_function	U1 snRNP binding
Q	1990447	molecular_function	U2 snRNP binding
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003676	molecular_function	nucleic acid binding
S	0003723	molecular_function	RNA binding
S	0003729	molecular_function	mRNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005685	cellular_component	U1 snRNP
S	0016607	cellular_component	nuclear speck
S	0030619	molecular_function	U1 snRNA binding
S	0043202	cellular_component	lysosomal lumen
S	0043484	biological_process	regulation of RNA splicing
S	0061084	biological_process	negative regulation of protein refolding
S	0071004	cellular_component	U2-type prespliceosome
S	0071011	cellular_component	precatalytic spliceosome
S	0071300	biological_process	cellular response to retinoic acid
S	0071356	biological_process	cellular response to tumor necrosis factor
S	0071560	biological_process	cellular response to transforming growth factor beta stimulus
S	1904715	biological_process	negative regulation of chaperone-mediated autophagy
S	1990446	molecular_function	U1 snRNP binding
U	0000243	cellular_component	commitment complex
U	0000244	biological_process	spliceosomal tri-snRNP complex assembly
U	0000245	biological_process	spliceosomal complex assembly
U	0000387	biological_process	spliceosomal snRNP assembly
U	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0005682	cellular_component	U5 snRNP
U	0005684	cellular_component	U2-type spliceosomal complex
U	0005685	cellular_component	U1 snRNP
U	0005686	cellular_component	U2 snRNP
U	0005687	cellular_component	U4 snRNP
U	0005689	cellular_component	U12-type spliceosomal complex
U	0005690	cellular_component	U4atac snRNP
U	0005829	cellular_component	cytosol
U	0006396	biological_process	RNA processing
U	0008380	biological_process	RNA splicing
U	0030532	cellular_component	small nuclear ribonucleoprotein complex
U	0034693	cellular_component	U11/U12 snRNP
U	0034709	cellular_component	methylosome
U	0034715	cellular_component	pICln-Sm protein complex
U	0034719	cellular_component	SMN-Sm protein complex
U	0036261	biological_process	7-methylguanosine cap hypermethylation
U	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
U	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
U	0071001	cellular_component	U4/U6 snRNP
U	0071002	cellular_component	U4atac/U6atac snRNP
U	0071005	cellular_component	U2-type precatalytic spliceosome
U	0071006	cellular_component	U2-type catalytic step 1 spliceosome
U	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
U	0071011	cellular_component	precatalytic spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
U	0071014	cellular_component	post-mRNA release spliceosomal complex
U	0071016	cellular_component	U12-type precatalytic spliceosome
U	0071018	cellular_component	U12-type catalytic step 2 spliceosome
U	0071020	cellular_component	post-spliceosomal complex
U	0097526	cellular_component	spliceosomal tri-snRNP complex
U	1903241	biological_process	U2-type prespliceosome assembly
U	1990446	molecular_function	U1 snRNP binding
V	0000244	biological_process	spliceosomal tri-snRNP complex assembly
V	0000245	biological_process	spliceosomal complex assembly
V	0000387	biological_process	spliceosomal snRNP assembly
V	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0005682	cellular_component	U5 snRNP
V	0005684	cellular_component	U2-type spliceosomal complex
V	0005685	cellular_component	U1 snRNP
V	0005686	cellular_component	U2 snRNP
V	0005687	cellular_component	U4 snRNP
V	0005689	cellular_component	U12-type spliceosomal complex
V	0005690	cellular_component	U4atac snRNP
V	0005829	cellular_component	cytosol
V	0008380	biological_process	RNA splicing
V	0030532	cellular_component	small nuclear ribonucleoprotein complex
V	0034693	cellular_component	U11/U12 snRNP
V	0034709	cellular_component	methylosome
V	0034715	cellular_component	pICln-Sm protein complex
V	0034719	cellular_component	SMN-Sm protein complex
V	0036261	biological_process	7-methylguanosine cap hypermethylation
V	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
V	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
V	0070062	cellular_component	extracellular exosome
V	0071001	cellular_component	U4/U6 snRNP
V	0071002	cellular_component	U4atac/U6atac snRNP
V	0071005	cellular_component	U2-type precatalytic spliceosome
V	0071006	cellular_component	U2-type catalytic step 1 spliceosome
V	0071007	cellular_component	U2-type catalytic step 2 spliceosome
V	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
V	0071011	cellular_component	precatalytic spliceosome
V	0071013	cellular_component	catalytic step 2 spliceosome
V	0071014	cellular_component	post-mRNA release spliceosomal complex
V	0071016	cellular_component	U12-type precatalytic spliceosome
V	0071018	cellular_component	U12-type catalytic step 2 spliceosome
V	0071020	cellular_component	post-spliceosomal complex
V	0097525	cellular_component	spliceosomal snRNP complex
V	1903241	biological_process	U2-type prespliceosome assembly
W	0000243	cellular_component	commitment complex
W	0000244	biological_process	spliceosomal tri-snRNP complex assembly
W	0000245	biological_process	spliceosomal complex assembly
W	0000387	biological_process	spliceosomal snRNP assembly
W	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0005682	cellular_component	U5 snRNP
W	0005683	cellular_component	U7 snRNP
W	0005684	cellular_component	U2-type spliceosomal complex
W	0005685	cellular_component	U1 snRNP
W	0005686	cellular_component	U2 snRNP
W	0005687	cellular_component	U4 snRNP
W	0005689	cellular_component	U12-type spliceosomal complex
W	0005690	cellular_component	U4atac snRNP
W	0005697	cellular_component	telomerase holoenzyme complex
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006396	biological_process	RNA processing
W	0006479	biological_process	protein methylation
W	0008380	biological_process	RNA splicing
W	0016604	cellular_component	nuclear body
W	0019899	molecular_function	enzyme binding
W	0030532	cellular_component	small nuclear ribonucleoprotein complex
W	0034693	cellular_component	U11/U12 snRNP
W	0034709	cellular_component	methylosome
W	0034715	cellular_component	pICln-Sm protein complex
W	0034719	cellular_component	SMN-Sm protein complex
W	0036261	biological_process	7-methylguanosine cap hypermethylation
W	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
W	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
W	0070034	molecular_function	telomerase RNA binding
W	0071001	cellular_component	U4/U6 snRNP
W	0071002	cellular_component	U4atac/U6atac snRNP
W	0071005	cellular_component	U2-type precatalytic spliceosome
W	0071006	cellular_component	U2-type catalytic step 1 spliceosome
W	0071007	cellular_component	U2-type catalytic step 2 spliceosome
W	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
W	0071011	cellular_component	precatalytic spliceosome
W	0071013	cellular_component	catalytic step 2 spliceosome
W	0071014	cellular_component	post-mRNA release spliceosomal complex
W	0071016	cellular_component	U12-type precatalytic spliceosome
W	0071018	cellular_component	U12-type catalytic step 2 spliceosome
W	0071020	cellular_component	post-spliceosomal complex
W	0071045	biological_process	nuclear histone mRNA catabolic process
W	0071208	molecular_function	histone pre-mRNA DCP binding
W	0071209	molecular_function	U7 snRNA binding
W	0097526	cellular_component	spliceosomal tri-snRNP complex
W	1903241	biological_process	U2-type prespliceosome assembly
X	0000243	cellular_component	commitment complex
X	0000244	biological_process	spliceosomal tri-snRNP complex assembly
X	0000245	biological_process	spliceosomal complex assembly
X	0000387	biological_process	spliceosomal snRNP assembly
X	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0005682	cellular_component	U5 snRNP
X	0005684	cellular_component	U2-type spliceosomal complex
X	0005685	cellular_component	U1 snRNP
X	0005686	cellular_component	U2 snRNP
X	0005687	cellular_component	U4 snRNP
X	0005689	cellular_component	U12-type spliceosomal complex
X	0005690	cellular_component	U4atac snRNP
X	0005829	cellular_component	cytosol
X	0006396	biological_process	RNA processing
X	0008380	biological_process	RNA splicing
X	0030532	cellular_component	small nuclear ribonucleoprotein complex
X	0034693	cellular_component	U11/U12 snRNP
X	0034709	cellular_component	methylosome
X	0034715	cellular_component	pICln-Sm protein complex
X	0034719	cellular_component	SMN-Sm protein complex
X	0036261	biological_process	7-methylguanosine cap hypermethylation
X	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
X	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
X	0071001	cellular_component	U4/U6 snRNP
X	0071002	cellular_component	U4atac/U6atac snRNP
X	0071005	cellular_component	U2-type precatalytic spliceosome
X	0071006	cellular_component	U2-type catalytic step 1 spliceosome
X	0071007	cellular_component	U2-type catalytic step 2 spliceosome
X	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
X	0071011	cellular_component	precatalytic spliceosome
X	0071013	cellular_component	catalytic step 2 spliceosome
X	0071014	cellular_component	post-mRNA release spliceosomal complex
X	0071016	cellular_component	U12-type precatalytic spliceosome
X	0071018	cellular_component	U12-type catalytic step 2 spliceosome
X	0071020	cellular_component	post-spliceosomal complex
X	0097526	cellular_component	spliceosomal tri-snRNP complex
X	1903241	biological_process	U2-type prespliceosome assembly
X	1990446	molecular_function	U1 snRNP binding
Y	0000244	biological_process	spliceosomal tri-snRNP complex assembly
Y	0000245	biological_process	spliceosomal complex assembly
Y	0000387	biological_process	spliceosomal snRNP assembly
Y	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0003723	molecular_function	RNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005681	cellular_component	spliceosomal complex
Y	0005682	cellular_component	U5 snRNP
Y	0005684	cellular_component	U2-type spliceosomal complex
Y	0005685	cellular_component	U1 snRNP
Y	0005686	cellular_component	U2 snRNP
Y	0005687	cellular_component	U4 snRNP
Y	0005689	cellular_component	U12-type spliceosomal complex
Y	0005690	cellular_component	U4atac snRNP
Y	0005829	cellular_component	cytosol
Y	0008380	biological_process	RNA splicing
Y	0030532	cellular_component	small nuclear ribonucleoprotein complex
Y	0034693	cellular_component	U11/U12 snRNP
Y	0034709	cellular_component	methylosome
Y	0034715	cellular_component	pICln-Sm protein complex
Y	0034719	cellular_component	SMN-Sm protein complex
Y	0036261	biological_process	7-methylguanosine cap hypermethylation
Y	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Y	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
Y	0070062	cellular_component	extracellular exosome
Y	0071001	cellular_component	U4/U6 snRNP
Y	0071002	cellular_component	U4atac/U6atac snRNP
Y	0071005	cellular_component	U2-type precatalytic spliceosome
Y	0071006	cellular_component	U2-type catalytic step 1 spliceosome
Y	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Y	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
Y	0071011	cellular_component	precatalytic spliceosome
Y	0071013	cellular_component	catalytic step 2 spliceosome
Y	0071014	cellular_component	post-mRNA release spliceosomal complex
Y	0071016	cellular_component	U12-type precatalytic spliceosome
Y	0071018	cellular_component	U12-type catalytic step 2 spliceosome
Y	0071020	cellular_component	post-spliceosomal complex
Y	0097525	cellular_component	spliceosomal snRNP complex
Y	1903241	biological_process	U2-type prespliceosome assembly
Z	0000243	cellular_component	commitment complex
Z	0000244	biological_process	spliceosomal tri-snRNP complex assembly
Z	0000245	biological_process	spliceosomal complex assembly
Z	0000387	biological_process	spliceosomal snRNP assembly
Z	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0003723	molecular_function	RNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005681	cellular_component	spliceosomal complex
Z	0005682	cellular_component	U5 snRNP
Z	0005683	cellular_component	U7 snRNP
Z	0005684	cellular_component	U2-type spliceosomal complex
Z	0005685	cellular_component	U1 snRNP
Z	0005686	cellular_component	U2 snRNP
Z	0005687	cellular_component	U4 snRNP
Z	0005689	cellular_component	U12-type spliceosomal complex
Z	0005690	cellular_component	U4atac snRNP
Z	0005697	cellular_component	telomerase holoenzyme complex
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0006396	biological_process	RNA processing
Z	0006479	biological_process	protein methylation
Z	0008380	biological_process	RNA splicing
Z	0016604	cellular_component	nuclear body
Z	0019899	molecular_function	enzyme binding
Z	0030532	cellular_component	small nuclear ribonucleoprotein complex
Z	0034693	cellular_component	U11/U12 snRNP
Z	0034709	cellular_component	methylosome
Z	0034715	cellular_component	pICln-Sm protein complex
Z	0034719	cellular_component	SMN-Sm protein complex
Z	0036261	biological_process	7-methylguanosine cap hypermethylation
Z	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Z	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
Z	0070034	molecular_function	telomerase RNA binding
Z	0071001	cellular_component	U4/U6 snRNP
Z	0071002	cellular_component	U4atac/U6atac snRNP
Z	0071005	cellular_component	U2-type precatalytic spliceosome
Z	0071006	cellular_component	U2-type catalytic step 1 spliceosome
Z	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Z	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
Z	0071011	cellular_component	precatalytic spliceosome
Z	0071013	cellular_component	catalytic step 2 spliceosome
Z	0071014	cellular_component	post-mRNA release spliceosomal complex
Z	0071016	cellular_component	U12-type precatalytic spliceosome
Z	0071018	cellular_component	U12-type catalytic step 2 spliceosome
Z	0071020	cellular_component	post-spliceosomal complex
Z	0071045	biological_process	nuclear histone mRNA catabolic process
Z	0071208	molecular_function	histone pre-mRNA DCP binding
Z	0071209	molecular_function	U7 snRNA binding
Z	0097526	cellular_component	spliceosomal tri-snRNP complex
Z	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	158
Details	Domain: {"description":"RRM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	156
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	62
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	66
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	504
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	158
Details	Region: {"description":"Sufficient for interaction with CLNS1A","evidences":[{"source":"PubMed","id":"11747828","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Matallanas D.","Cooper W.N.","Kolch W."]}},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---