3PDC
Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a benzoxazole inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ZYI A 1 |
| Chain | Residue |
| A | PHE265 |
| A | TRP524 |
| A | ASP333 |
| A | MET337 |
| A | TYR381 |
| A | GLN382 |
| A | LEU406 |
| A | LEU427 |
| A | TYR465 |
| A | HIS523 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ZYI B 2 |
| Chain | Residue |
| B | PHE265 |
| B | ASP333 |
| B | TRP334 |
| B | THR358 |
| B | TYR381 |
| B | GLN382 |
| B | LEU406 |
| B | LEU427 |
| B | TYR465 |
| B | HIS523 |
| B | TRP524 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | ASP333 | |
| B | ASP333 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | TYR465 | |
| B | TYR465 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | HIS523 | |
| B | HIS523 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 |
| Chain | Residue | Details |
| A | TYR381 | |
| B | TYR381 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P34914 |
| Chain | Residue | Details |
| A | SER368 | |
| B | SER368 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P34914 |
| Chain | Residue | Details |
| A | LYS420 | |
| A | LYS454 | |
| B | LYS420 | |
| B | LYS454 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | LIPID: S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine => ECO:0000305|PubMed:21164107 |
| Chain | Residue | Details |
| A | CYS521 | |
| B | CYS521 |
