3P8B
X-ray crystal structure of Pyrococcus furiosus transcription elongation factor Spt4/5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0003735 | molecular_function | structural constituent of ribosome |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005840 | cellular_component | ribosome |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006354 | biological_process | DNA-templated transcription elongation |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0032784 | biological_process | regulation of DNA-templated transcription elongation |
| C | 0005515 | molecular_function | protein binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003729 | molecular_function | mRNA binding |
| D | 0003735 | molecular_function | structural constituent of ribosome |
| D | 0003746 | molecular_function | translation elongation factor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005840 | cellular_component | ribosome |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0006354 | biological_process | DNA-templated transcription elongation |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| D | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| D | 0006412 | biological_process | translation |
| D | 0006414 | biological_process | translational elongation |
| D | 0032784 | biological_process | regulation of DNA-templated transcription elongation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 101 |
| Chain | Residue |
| A | CYS6 |
| A | CYS9 |
| A | CYS18 |
| A | CYS21 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BME A 62 |
| Chain | Residue |
| A | GLU3 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 153 |
| Chain | Residue |
| A | GLU3 |
| A | TRP30 |
| B | GLU16 |
| B | SER40 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 154 |
| Chain | Residue |
| A | ARG61 |
| A | HOH92 |
| B | GLU84 |
| B | LYS86 |
| B | ASP120 |
| B | ASP140 |
| B | HOH164 |
| D | PRO104 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 155 |
| Chain | Residue |
| B | GLY62 |
| B | HOH185 |
| C | VAL37 |
| C | ASP38 |
| D | ASN30 |
| D | LEU31 |
| D | ILE33 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BME B 156 |
| Chain | Residue |
| A | VAL37 |
| A | ASP38 |
| B | VAL26 |
| B | ASN30 |
| B | LEU31 |
| B | ILE33 |
| D | ARG61 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME B 157 |
| Chain | Residue |
| B | GLN108 |
| B | LYS109 |
| B | ILE127 |
| B | ASP128 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME B 158 |
| Chain | Residue |
| B | PHE105 |
| B | PHE126 |
| B | ALA129 |
| B | VAL131 |
| B | HOH171 |
| D | GLU78 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 101 |
| Chain | Residue |
| C | CYS6 |
| C | CYS9 |
| C | CYS18 |
| C | CYS21 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 153 |
| Chain | Residue |
| C | TRP30 |
| D | GLU16 |
| D | SER40 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 154 |
| Chain | Residue |
| D | ARG9 |
| D | VAL10 |
| D | HIS12 |
| D | GLY44 |
| D | TYR45 |
| D | HOH164 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME D 155 |
| Chain | Residue |
| B | GLU78 |
| D | PHE126 |
| D | ALA129 |
| D | VAL131 |
| D | ILE133 |
| D | HOH190 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME D 156 |
| Chain | Residue |
| B | THR136 |
| B | ILE137 |
| B | LYS138 |
| B | TYR141 |
| D | ARG41 |
Functional Information from PROSITE/UniProt
| site_id | PS01108 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L24 Ribosomal protein L24 signature. GDlVeVIaGpfKGqk.AkV |
| Chain | Residue | Details |
| B | GLY95-VAL112 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00949","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21187417","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21386817","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Domain: {"description":"KOW","evidences":[{"source":"HAMAP-Rule","id":"MF_00950","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
