3P48

Structure of the yeast dUTPase DUT1 in complex with dUMPNPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006226	biological_process	dUMP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035863	biological_process	dITP catabolic process
A	0035870	molecular_function	dITP diphosphatase activity
A	0046081	biological_process	dUTP catabolic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004170	molecular_function	dUTP diphosphatase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006226	biological_process	dUMP biosynthetic process
B	0009117	biological_process	nucleotide metabolic process
B	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035863	biological_process	dITP catabolic process
B	0035870	molecular_function	dITP diphosphatase activity
B	0046081	biological_process	dUTP catabolic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004170	molecular_function	dUTP diphosphatase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006226	biological_process	dUMP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
C	0016787	molecular_function	hydrolase activity
C	0035863	biological_process	dITP catabolic process
C	0035870	molecular_function	dITP diphosphatase activity
C	0046081	biological_process	dUTP catabolic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DUP A 148

Chain	Residue
A	ARG68
A	HOH186
A	HOH211
A	HOH246
A	HOH247
A	HOH260
A	HOH406
C	LYS74
C	ALA81
C	GLY82
C	VAL83
A	SER69
C	ASP85
C	TYR88
C	LYS93
A	GLY70
A	GLN114
A	MG149
A	HOH164
A	HOH168
A	HOH176
A	HOH178

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 149

Chain	Residue
A	DUP148
A	HOH168
A	HOH246
A	HOH247

---

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE DUP B 148

Chain	Residue
A	ALA81
A	GLY82
A	VAL83
A	ASP85
A	TYR88
A	VAL92
A	LYS93
B	ARG68
B	SER69
B	GLY70
B	GLN114
B	MG150
B	HOH161
B	HOH175
B	HOH180
B	HOH207
B	HOH214
B	HOH219
B	HOH248
B	HOH249
B	HOH250
B	HOH257
B	HOH396

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DUP B 149

Chain	Residue
B	ALA81
B	GLY82
B	VAL83
B	ASP85
B	TYR88
B	VAL92
B	LYS93
B	HOH190
B	HOH225
B	HOH234
B	HOH276
B	HOH377
C	MET48
C	ARG68
C	SER69
C	GLY70
C	GLN114
C	MG148

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 150

Chain	Residue
B	DUP148
B	HOH248
B	HOH249
B	HOH250

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 148

Chain	Residue
B	DUP149
B	HOH276
C	ASP32

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21548881","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3F4F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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