3P48
Structure of the yeast dUTPase DUT1 in complex with dUMPNPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004170 | molecular_function | dUTP diphosphatase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006226 | biological_process | dUMP biosynthetic process |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0009213 | biological_process | pyrimidine deoxyribonucleoside triphosphate catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035863 | biological_process | dITP catabolic process |
| A | 0035870 | molecular_function | dITP diphosphatase activity |
| A | 0046081 | biological_process | dUTP catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004170 | molecular_function | dUTP diphosphatase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006226 | biological_process | dUMP biosynthetic process |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0009213 | biological_process | pyrimidine deoxyribonucleoside triphosphate catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0035863 | biological_process | dITP catabolic process |
| B | 0035870 | molecular_function | dITP diphosphatase activity |
| B | 0046081 | biological_process | dUTP catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004170 | molecular_function | dUTP diphosphatase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006226 | biological_process | dUMP biosynthetic process |
| C | 0009117 | biological_process | nucleotide metabolic process |
| C | 0009213 | biological_process | pyrimidine deoxyribonucleoside triphosphate catabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0035863 | biological_process | dITP catabolic process |
| C | 0035870 | molecular_function | dITP diphosphatase activity |
| C | 0046081 | biological_process | dUTP catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE DUP A 148 |
| Chain | Residue |
| A | ARG68 |
| A | HOH186 |
| A | HOH211 |
| A | HOH246 |
| A | HOH247 |
| A | HOH260 |
| A | HOH406 |
| C | LYS74 |
| C | ALA81 |
| C | GLY82 |
| C | VAL83 |
| A | SER69 |
| C | ASP85 |
| C | TYR88 |
| C | LYS93 |
| A | GLY70 |
| A | GLN114 |
| A | MG149 |
| A | HOH164 |
| A | HOH168 |
| A | HOH176 |
| A | HOH178 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 149 |
| Chain | Residue |
| A | DUP148 |
| A | HOH168 |
| A | HOH246 |
| A | HOH247 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE DUP B 148 |
| Chain | Residue |
| A | ALA81 |
| A | GLY82 |
| A | VAL83 |
| A | ASP85 |
| A | TYR88 |
| A | VAL92 |
| A | LYS93 |
| B | ARG68 |
| B | SER69 |
| B | GLY70 |
| B | GLN114 |
| B | MG150 |
| B | HOH161 |
| B | HOH175 |
| B | HOH180 |
| B | HOH207 |
| B | HOH214 |
| B | HOH219 |
| B | HOH248 |
| B | HOH249 |
| B | HOH250 |
| B | HOH257 |
| B | HOH396 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE DUP B 149 |
| Chain | Residue |
| B | ALA81 |
| B | GLY82 |
| B | VAL83 |
| B | ASP85 |
| B | TYR88 |
| B | VAL92 |
| B | LYS93 |
| B | HOH190 |
| B | HOH225 |
| B | HOH234 |
| B | HOH276 |
| B | HOH377 |
| C | MET48 |
| C | ARG68 |
| C | SER69 |
| C | GLY70 |
| C | GLN114 |
| C | MG148 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 150 |
| Chain | Residue |
| B | DUP148 |
| B | HOH248 |
| B | HOH249 |
| B | HOH250 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 148 |
| Chain | Residue |
| B | DUP149 |
| B | HOH276 |
| C | ASP32 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21548881, ECO:0007744|PDB:3F4F |
| Chain | Residue | Details |
| A | SER69 | |
| B | GLY82 | |
| B | ASP85 | |
| B | TYR88 | |
| B | LYS93 | |
| B | ARG137 | |
| B | PHE142 | |
| B | GLY143 | |
| C | SER69 | |
| C | GLY82 | |
| C | ASP85 | |
| A | GLY82 | |
| C | TYR88 | |
| C | LYS93 | |
| C | ARG137 | |
| C | PHE142 | |
| C | GLY143 | |
| A | ASP85 | |
| A | TYR88 | |
| A | LYS93 | |
| A | ARG137 | |
| A | PHE142 | |
| A | GLY143 | |
| B | SER69 |
