3P45

Crystal structure of apo-caspase-6 at physiological pH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0008234	molecular_function	cysteine-type peptidase activity
F	0004197	molecular_function	cysteine-type endopeptidase activity
F	0006508	biological_process	proteolysis
F	0008234	molecular_function	cysteine-type peptidase activity
G	0004197	molecular_function	cysteine-type endopeptidase activity
G	0006508	biological_process	proteolysis
G	0008234	molecular_function	cysteine-type peptidase activity
H	0004197	molecular_function	cysteine-type endopeptidase activity
H	0006508	biological_process	proteolysis
H	0008234	molecular_function	cysteine-type peptidase activity
I	0004197	molecular_function	cysteine-type endopeptidase activity
I	0006508	biological_process	proteolysis
I	0008234	molecular_function	cysteine-type peptidase activity
J	0004197	molecular_function	cysteine-type endopeptidase activity
J	0006508	biological_process	proteolysis
J	0008234	molecular_function	cysteine-type peptidase activity
K	0004197	molecular_function	cysteine-type endopeptidase activity
K	0006508	biological_process	proteolysis
K	0008234	molecular_function	cysteine-type peptidase activity
L	0004197	molecular_function	cysteine-type endopeptidase activity
L	0006508	biological_process	proteolysis
L	0008234	molecular_function	cysteine-type peptidase activity
M	0004197	molecular_function	cysteine-type endopeptidase activity
M	0006508	biological_process	proteolysis
M	0008234	molecular_function	cysteine-type peptidase activity
N	0004197	molecular_function	cysteine-type endopeptidase activity
N	0006508	biological_process	proteolysis
N	0008234	molecular_function	cysteine-type peptidase activity
O	0004197	molecular_function	cysteine-type endopeptidase activity
O	0006508	biological_process	proteolysis
O	0008234	molecular_function	cysteine-type peptidase activity
P	0004197	molecular_function	cysteine-type endopeptidase activity
P	0006508	biological_process	proteolysis
P	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HadadCfvCvFLSHG

Chain	Residue	Details
A	HIS108-GLY122

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site_id	PS01122
Number of Residues	12
Details	CASPASE_CYS Caspase family cysteine active site. KPKIFIIQACRG

Chain	Residue	Details
A	LYS154-GLY165

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: Phosphoserine; by NUAK1 and AMPK => ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:22483120, ECO:0000269|PubMed:32029622

Chain	Residue	Details
B	SER257
D	SER257
F	SER257
H	SER257
J	SER257
L	SER257
N	SER257
P	SER257

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site_id	SWS_FT_FI2
Number of Residues	16
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:27911442

Chain	Residue	Details
B	CYS264
J	CYS277
L	CYS264
L	CYS277
N	CYS264
N	CYS277
P	CYS264
P	CYS277
B	CYS277
D	CYS264
D	CYS277
F	CYS264
F	CYS277
H	CYS264
H	CYS277
J	CYS264

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site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08738

Chain	Residue	Details
A	SER79
C	SER79
E	SER79
G	SER79
I	SER79
K	SER79
M	SER79
O	SER79

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