3P35
Polo-like kinase I Polo-box domain in complex with MQSpSPL phosphopeptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 595 |
| Chain | Residue |
| A | ASN385 |
| A | PRO389 |
| A | ALA577 |
| A | ARG581 |
| B | GLU504 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 596 |
| Chain | Residue |
| B | GLN536 |
| B | ASP537 |
| B | HIS538 |
| A | ARG507 |
| A | LEU508 |
| A | TYR510 |
| A | SER526 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 595 |
| Chain | Residue |
| B | THR459 |
| B | GLU460 |
| B | HOH601 |
| C | HOH10 |
| C | TRP414 |
| C | LEU490 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 596 |
| Chain | Residue |
| B | LEU566 |
| B | GLU569 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 597 |
| Chain | Residue |
| B | TYR421 |
| B | PHE436 |
| B | ASN437 |
| B | ASP438 |
| B | LYS475 |
| B | HOH598 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 234 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 246 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Region: {"description":"Linker"} |
| Chain | Residue | Details |
