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3OTK

Structure and mechanisim of core 2 beta1,6-n-acetylglucosaminyltransferase: a Metal-ion independent gt-a glycosyltransferase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0003829molecular_functionbeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
A0005615cellular_componentextracellular space
A0005794cellular_componentGolgi apparatus
A0005802cellular_componenttrans-Golgi network
A0006486biological_processprotein glycosylation
A0009101biological_processglycoprotein biosynthetic process
A0016020cellular_componentmembrane
A0016268biological_processO-glycan processing, core 2
A0016757molecular_functionglycosyltransferase activity
A0031985cellular_componentGolgi cisterna
A0032868biological_processresponse to insulin
A0048729biological_processtissue morphogenesis
A0050901biological_processleukocyte tethering or rolling
A0060352biological_processcell adhesion molecule production
A0060993biological_processkidney morphogenesis
A1903238biological_processpositive regulation of leukocyte tethering or rolling
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0003829molecular_functionbeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
B0005615cellular_componentextracellular space
B0005794cellular_componentGolgi apparatus
B0005802cellular_componenttrans-Golgi network
B0006486biological_processprotein glycosylation
B0009101biological_processglycoprotein biosynthetic process
B0016020cellular_componentmembrane
B0016268biological_processO-glycan processing, core 2
B0016757molecular_functionglycosyltransferase activity
B0031985cellular_componentGolgi cisterna
B0032868biological_processresponse to insulin
B0048729biological_processtissue morphogenesis
B0050901biological_processleukocyte tethering or rolling
B0060352biological_processcell adhesion molecule production
B0060993biological_processkidney morphogenesis
B1903238biological_processpositive regulation of leukocyte tethering or rolling
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0003829molecular_functionbeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
C0005615cellular_componentextracellular space
C0005794cellular_componentGolgi apparatus
C0005802cellular_componenttrans-Golgi network
C0006486biological_processprotein glycosylation
C0009101biological_processglycoprotein biosynthetic process
C0016020cellular_componentmembrane
C0016268biological_processO-glycan processing, core 2
C0016757molecular_functionglycosyltransferase activity
C0031985cellular_componentGolgi cisterna
C0032868biological_processresponse to insulin
C0048729biological_processtissue morphogenesis
C0050901biological_processleukocyte tethering or rolling
C0060352biological_processcell adhesion molecule production
C0060993biological_processkidney morphogenesis
C1903238biological_processpositive regulation of leukocyte tethering or rolling
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0003829molecular_functionbeta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
D0005615cellular_componentextracellular space
D0005794cellular_componentGolgi apparatus
D0005802cellular_componenttrans-Golgi network
D0006486biological_processprotein glycosylation
D0009101biological_processglycoprotein biosynthetic process
D0016020cellular_componentmembrane
D0016268biological_processO-glycan processing, core 2
D0016757molecular_functionglycosyltransferase activity
D0031985cellular_componentGolgi cisterna
D0032868biological_processresponse to insulin
D0048729biological_processtissue morphogenesis
D0050901biological_processleukocyte tethering or rolling
D0060352biological_processcell adhesion molecule production
D0060993biological_processkidney morphogenesis
D1903238biological_processpositive regulation of leukocyte tethering or rolling
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:16829524
ChainResidueDetails
AGLU320
BGLU320
CGLU320
DGLU320

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:22056345, ECO:0007744|PDB:3OTK
ChainResidueDetails
AVAL128
BLYS401
CVAL128
CASP155
CTYR187
CARG378
CLYS401
DVAL128
DASP155
DTYR187
DARG378
AASP155
DLYS401
ATYR187
AARG378
ALYS401
BVAL128
BASP155
BTYR187
BARG378

site_idSWS_FT_FI3
Number of Residues28
DetailsBINDING: BINDING => ECO:0000269|PubMed:16829524, ECO:0007744|PDB:2GAM
ChainResidueDetails
AGLU243
BLYS251
BARG254
BGLU320
BLYS341
BTYR358
CGLU243
CASN250
CLYS251
CARG254
CGLU320
AASN250
CLYS341
CTYR358
DGLU243
DASN250
DLYS251
DARG254
DGLU320
DLYS341
DTYR358
ALYS251
AARG254
AGLU320
ALYS341
ATYR358
BGLU243
BASN250

site_idSWS_FT_FI4
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12954635, ECO:0000269|PubMed:16829524, ECO:0000269|PubMed:22056345, ECO:0007744|PDB:2GAK, ECO:0007744|PDB:3OTK
ChainResidueDetails
AASN58
AASN95
BASN58
BASN95
CASN58
CASN95
DASN58
DASN95

222624

PDB entries from 2024-07-17

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