3OQ3
Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002286 | biological_process | T cell activation involved in immune response |
| A | 0002312 | biological_process | B cell activation involved in immune response |
| A | 0002323 | biological_process | natural killer cell activation involved in immune response |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005126 | molecular_function | cytokine receptor binding |
| A | 0005132 | molecular_function | type I interferon receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006952 | biological_process | defense response |
| A | 0006959 | biological_process | humoral immune response |
| A | 0043330 | biological_process | response to exogenous dsRNA |
| A | 0051607 | biological_process | defense response to virus |
| A | 0060337 | biological_process | type I interferon-mediated signaling pathway |
| B | 0005576 | cellular_component | extracellular region |
| B | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 167 |
| Chain | Residue |
| A | HIS7 |
| A | CL168 |
| B | HIS140 |
| B | ACT329 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 168 |
| Chain | Residue |
| A | HIS7 |
| A | ZN167 |
| B | HIS140 |
| B | ACT329 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 169 |
| Chain | Residue |
| A | GLN92 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 170 |
| Chain | Residue |
| A | ASN11 |
| A | THR61 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 329 |
| Chain | Residue |
| A | HIS7 |
| A | ZN167 |
| A | CL168 |
| B | HIS140 |
| B | ILE145 |
| B | ASP146 |
| B | HOH515 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 330 |
| Chain | Residue |
| B | ARG195 |
| B | ASN246 |
| B | TYR295 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 331 |
| Chain | Residue |
| B | SER285 |
| B | EPE333 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 332 |
| Chain | Residue |
| B | HOH585 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EPE B 333 |
| Chain | Residue |
| A | ARG22 |
| A | HOH171 |
| B | ASN165 |
| B | ASN166 |
| B | ARG195 |
| B | THR248 |
| B | THR284 |
| B | GLU291 |
| B | EDO331 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EPE B 334 |
| Chain | Residue |
| B | TYR163 |
| B | ASN166 |
| B | TYR199 |
| B | HIS201 |
| B | SER286 |
Functional Information from PROSITE/UniProt
| site_id | PS00252 |
| Number of Residues | 19 |
| Details | INTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFhRItvYLrekkhspCAW |
| Chain | Residue | Details |
| A | TYR123-TRP141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
