3OOI

Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 232

Chain	Residue
A	CYS172
A	CYS219
A	CYS221
A	CYS226

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 233

Chain	Residue
A	CYS44
A	CYS46
A	CYS54
A	CYS60

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 234

Chain	Residue
A	CYS69
A	CYS74
A	CYS80
A	CYS54

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 235

Chain	Residue
A	GLY77
A	GLY78
A	THR98
A	LEU99
A	GLN100
A	ARG101
A	HOH322
A	HOH383
A	HOH585
A	HOH607

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 236

Chain	Residue
A	ILE22
A	LYS23
A	VAL24
A	ARG26
A	HOH414

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAM A 237

Chain	Residue
A	ARG101
A	TRP103
A	THR143
A	ASN144
A	PHE145
A	TYR146
A	ARG166
A	ASN169
A	HIS170
A	TYR207
A	ASN214
A	VAL218
A	CYS219
A	LYS220
A	LEU230
A	HOH277
A	HOH278
A	HOH366
A	HOH401
A	HOH458

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Domain: {"description":"AWS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00562","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	117
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Region: {"description":"Inhibits enzyme activity in the absence of bound histone"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21196496","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---