3OJU

Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing c5 modified thymidies

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001882	molecular_function	nucleoside binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE SSJ A 1

Chain	Residue
A	MG2
A	SER612
A	GLN613
A	ILE614
A	GLU615
A	HIS639
A	ARG659
A	ARG660
A	LYS663
A	THR664
A	PHE667
A	MG3
A	ASP785
B	DC111
B	DOC112
C	DA204
C	DG205
A	HOH33
A	HOH70
A	HOH126
A	ARG573
A	ARG587
A	ASP610
A	TYR611

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 2

Chain	Residue
A	SSJ1
A	ASP610
A	TYR611
A	ASP785

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 3

Chain	Residue
A	SSJ1
A	HOH33
A	ASP610
A	ASP785

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 4

Chain	Residue
A	HOH163
A	LYS354
A	ASP355
A	ASN565
A	GLN566

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 5

Chain	Residue
A	THR544
A	PRO579
A	ASN580
A	ASN583
C	HOH22
C	DC209
C	DC210

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 6

Chain	Residue
A	GOL9
A	HOH157
A	ASN485
B	DG107
C	DG211
C	DT212

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE A 7

Chain	Residue
A	GLU347
A	ARG349
A	GLY370
A	ASP371

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE A 8

Chain	Residue
A	GLU745
A	ARG746

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 9

Chain	Residue
A	GOL6
A	ASN485
A	SER486
A	ARG487
A	ASP488
B	HOH31
C	DG211
C	DT212
C	DG213

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGE A 10

Chain	Residue
A	HOH42
A	HOH131
A	HOH131
A	LYS767
A	LYS767
A	ARG771
A	VAL810

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE A 11

Chain	Residue
A	ASP371
A	ARG435

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE A 12

Chain	Residue
A	ARG313
A	GLU315
A	TRP318
A	LEU552

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE A 13

Chain	Residue
A	GLY396
A	GLU397
A	GLU404
A	ARG411

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE A 14

Chain	Residue
A	SER460
A	LYS542

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 15

Chain	Residue
A	ARG425
A	TRP428
A	PHE724

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE A 16

Chain	Residue
A	THR447
A	ARG778

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGE A 17

Chain	Residue
A	GLY479

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE A 18

Chain	Residue
A	HOH124
A	LYS508
A	THR509
A	GLU734
A	ALA735

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 1

Chain	Residue
C	DC207
A	ARG728
A	MET747
C	PGE2
C	DG206

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE C 2

Chain	Residue
C	GOL1
C	HOH31
C	DG205
C	DG206
C	DC207

---

Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RraAKtinFGvlYgmSahrL

Chain	Residue	Details
A	ARG659-LEU678

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	422
Details	Region: {"description":"Polymerase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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