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3OEF

Crystal structure of Y323F inactive mutant of p38alpha MAP kinase

Functional Information from GO Data
ChainGOidnamespacecontents
X0000077biological_processDNA damage checkpoint signaling
X0000165biological_processMAPK cascade
X0000166molecular_functionnucleotide binding
X0000902biological_processcell morphogenesis
X0000922cellular_componentspindle pole
X0001502biological_processcartilage condensation
X0001525biological_processangiogenesis
X0001649biological_processosteoblast differentiation
X0001890biological_processplacenta development
X0002021biological_processresponse to dietary excess
X0002062biological_processchondrocyte differentiation
X0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
X0004672molecular_functionprotein kinase activity
X0004674molecular_functionprotein serine/threonine kinase activity
X0004707molecular_functionMAP kinase activity
X0004708molecular_functionMAP kinase kinase activity
X0005515molecular_functionprotein binding
X0005524molecular_functionATP binding
X0005576cellular_componentextracellular region
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005737cellular_componentcytoplasm
X0005739cellular_componentmitochondrion
X0005829cellular_componentcytosol
X0006006biological_processglucose metabolic process
X0006355biological_processregulation of DNA-templated transcription
X0006357biological_processregulation of transcription by RNA polymerase II
X0006366biological_processtranscription by RNA polymerase II
X0006468biological_processprotein phosphorylation
X0006915biological_processapoptotic process
X0006935biological_processchemotaxis
X0006974biological_processDNA damage response
X0007165biological_processsignal transduction
X0007166biological_processcell surface receptor signaling pathway
X0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
X0007519biological_processskeletal muscle tissue development
X0010628biological_processpositive regulation of gene expression
X0010831biological_processpositive regulation of myotube differentiation
X0016301molecular_functionkinase activity
X0016310biological_processphosphorylation
X0016607cellular_componentnuclear speck
X0016740molecular_functiontransferase activity
X0018105biological_processpeptidyl-serine phosphorylation
X0019395biological_processfatty acid oxidation
X0019899molecular_functionenzyme binding
X0019903molecular_functionprotein phosphatase binding
X0030168biological_processplatelet activation
X0030278biological_processregulation of ossification
X0030316biological_processosteoclast differentiation
X0031098biological_processstress-activated protein kinase signaling cascade
X0031281biological_processpositive regulation of cyclase activity
X0031663biological_processlipopolysaccharide-mediated signaling pathway
X0032495biological_processresponse to muramyl dipeptide
X0032496biological_processresponse to lipopolysaccharide
X0032735biological_processpositive regulation of interleukin-12 production
X0032868biological_processresponse to insulin
X0033554biological_processcellular response to stress
X0034774cellular_componentsecretory granule lumen
X0035331biological_processnegative regulation of hippo signaling
X0035556biological_processintracellular signal transduction
X0035924biological_processcellular response to vascular endothelial growth factor stimulus
X0035994biological_processresponse to muscle stretch
X0038066biological_processp38MAPK cascade
X0042307biological_processpositive regulation of protein import into nucleus
X0042770biological_processsignal transduction in response to DNA damage
X0043536biological_processpositive regulation of blood vessel endothelial cell migration
X0045648biological_processpositive regulation of erythrocyte differentiation
X0045663biological_processpositive regulation of myoblast differentiation
X0045944biological_processpositive regulation of transcription by RNA polymerase II
X0046323biological_processglucose import
X0046326biological_processpositive regulation of glucose import
X0048010biological_processvascular endothelial growth factor receptor signaling pathway
X0048273molecular_functionmitogen-activated protein kinase p38 binding
X0048863biological_processstem cell differentiation
X0051146biological_processstriated muscle cell differentiation
X0051149biological_processpositive regulation of muscle cell differentiation
X0051403biological_processstress-activated MAPK cascade
X0051525molecular_functionNFAT protein binding
X0060045biological_processpositive regulation of cardiac muscle cell proliferation
X0060348biological_processbone development
X0070935biological_process3'-UTR-mediated mRNA stabilization
X0071222biological_processcellular response to lipopolysaccharide
X0071223biological_processcellular response to lipoteichoic acid
X0071356biological_processcellular response to tumor necrosis factor
X0071479biological_processcellular response to ionizing radiation
X0071493biological_processcellular response to UV-B
X0090090biological_processnegative regulation of canonical Wnt signaling pathway
X0090336biological_processpositive regulation of brown fat cell differentiation
X0090398biological_processcellular senescence
X0090400biological_processstress-induced premature senescence
X0098586biological_processcellular response to virus
X0098978cellular_componentglutamatergic synapse
X0099179biological_processregulation of synaptic membrane adhesion
X0106310molecular_functionprotein serine kinase activity
X1900015biological_processregulation of cytokine production involved in inflammatory response
X1901741biological_processpositive regulation of myoblast fusion
X1904813cellular_componentficolin-1-rich granule lumen
X2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK
ChainResidueDetails
XVAL30-LYS54

site_idPS01351
Number of Residues104
DetailsMAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
ChainResidueDetails
XPHE59-CYS162

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
XASP168

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
XVAL30
XLYS53

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
XSER2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
XTHR16

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21444723
ChainResidueDetails
XLYS53
XLYS152

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
XTHR180

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000269|PubMed:7535770, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
XTYR182

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17525332
ChainResidueDetails
XTHR263

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by ZAP70 => ECO:0000269|PubMed:15735648
ChainResidueDetails
XPHE323

218853

PDB entries from 2024-04-24

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