3O78

The structure of Ca2+ Sensor (Case-12)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0006091	biological_process	generation of precursor metabolites and energy
A	0008218	biological_process	bioluminescence
B	0005509	molecular_function	calcium ion binding
B	0006091	biological_process	generation of precursor metabolites and energy
B	0008218	biological_process	bioluminescence

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	ASP289
A	ASP291
A	ASP293
A	THR295
A	GLU300

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	GLU336
A	ASP325
A	ASP327
A	ASN329
A	THR331

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ASP362
A	ASP364
A	ASN366
A	TYR368
A	GLU373

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 504

Chain	Residue
A	ASP398
A	ASP400
A	ASP402
A	GLN404
A	GLU409
A	HOH448

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 501

Chain	Residue
B	ASP289
B	ASP291
B	ASP293
B	THR295
B	GLU300

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 502

Chain	Residue
B	ASP325
B	ASP327
B	ASN329
B	THR331
B	GLU336

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 503

Chain	Residue
B	ASP362
B	ASP364
B	ASN366
B	TYR368
B	GLU373

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 504

Chain	Residue
B	ASP398
B	ASP400
B	ASP402
B	GLN404
B	GLU409

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
A	ASP291-THR303
A	ASP327-THR339
A	ASP364-HIS376
A	ASP400-GLN412

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:12176732

Chain	Residue	Details
A	ASN37
B	ASN37

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132

Chain	Residue	Details
A	LEU192
B	LEU192

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132

Chain	Residue	Details
A	CR2190
A	LYS193
B	CR2190
B	LYS193

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03

Chain	Residue	Details
A	ASP289
A	GLU336
B	ASP289
B	ASP291
B	ASP293
B	THR295
B	GLU300
B	ASP325
B	ASP327
B	ASN329
B	THR331
A	ASP291
B	GLU336
A	ASP293
A	THR295
A	GLU300
A	ASP325
A	ASP327
A	ASN329
A	THR331

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03

Chain	Residue	Details
A	ASP362
A	GLU409
B	ASP362
B	ASP364
B	ASN366
B	TYR368
B	GLU373
B	ASP398
B	ASP400
B	ASP402
B	GLN404
A	ASP364
B	GLU409
A	ASN366
A	TYR368
A	GLU373
A	ASP398
A	ASP400
A	ASP402
A	GLN404

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS290
B	LYS290

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
A	THR313
B	THR313

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER350
B	SER350

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS363
B	LYS363

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	TYR368
B	TYR368

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER370
B	SER370

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR379
B	THR379

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
A	LYS384
B	LYS384

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	TYR407
B	TYR407

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
A	LYS290
B	LYS290

---