3O4S
Crystal Structure of HePTP with a Closed WPD Loop and an Ordered E-Loop
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | ASP236 |
| A | HOH425 |
| A | CYS270 |
| A | SER271 |
| A | ALA272 |
| A | GLY273 |
| A | ILE274 |
| A | GLY275 |
| A | ARG276 |
| A | GLN314 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | THR174 |
| A | GLN175 |
| A | LYS182 |
| A | ASP236 |
| A | SER271 |
| A | ARG276 |
| A | HOH428 |
| A | HOH444 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | PRO60 |
| A | LEU61 |
| A | THR62 |
| A | ALA65 |
| A | GLU241 |
| A | SER242 |
| A | ALA243 |
| A | HIS324 |
| A | HOH553 |
| A | HOH631 |
| A | HOH635 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4 |
| Chain | Residue |
| A | HIS185 |
| A | TRP187 |
| A | PRO188 |
| A | THR189 |
| A | ARG213 |
| A | HOH431 |
| A | HOH620 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | ARG55 |
| A | ARG135 |
| A | GLU241 |
| A | LEU307 |
| A | HOH585 |
| A | HOH639 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | GLN121 |
| A | SER122 |
| A | GLN123 |
| A | GLY195 |
| A | PRO196 |
| A | HOH625 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 7 |
| Chain | Residue |
| A | PRO96 |
| A | GLY97 |
| A | HIS98 |
| A | ALA99 |
| A | GLU192 |
| A | TYR194 |
| A | HOH474 |
| A | HOH480 |
| A | HOH498 |
| A | HOH629 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 8 |
| Chain | Residue |
| A | TYR104 |
| A | LYS182 |
| A | ASP236 |
| A | HIS237 |
| A | HOH623 |
| A | HOH660 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 9 |
| Chain | Residue |
| A | PHE53 |
| A | THR56 |
| A | ALA57 |
| A | ARG63 |
| A | ALA330 |
| A | GLY331 |
| A | LEU333 |
| A | GLU335 |
| A | HOH472 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 10 |
| Chain | Residue |
| A | LEU66 |
| A | PRO70 |
| A | ARG293 |
| A | GLU295 |
| A | HIS323 |
| A | ALA327 |
| A | HOH479 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 11 |
| Chain | Residue |
| A | ASP94 |
| A | ARG114 |
| A | GLN123 |
| A | GLY179 |
| A | LYS180 |
| A | HOH616 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG |
| Chain | Residue | Details |
| A | VAL268-GLY278 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 253 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9624114","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"10206983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10206983","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
