Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006955 | biological_process | immune response |
| B | 0004908 | molecular_function | interleukin-1 receptor activity |
| C | 0004908 | molecular_function | interleukin-1 receptor activity |
| C | 0004910 | molecular_function | interleukin-1, type II, blocking receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00253 |
| Number of Residues | 21 |
| Details | INTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV |
| Chain | Residue | Details |
| A | PHE112-VAL132 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Motif: {"description":"Involved in interaction with TMED10 C-terminus","evidences":[{"source":"PubMed","id":"32272059","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in receptor binding"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"29030430","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 178 |
| Details | Domain: {"description":"Ig-like C2-type 2"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Region: {"description":"Contains proteolytic cleavage site","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20802483","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Region: {"description":"Essential for interaction with PTPRD","evidences":[{"source":"UniProtKB","id":"Q61730","evidenceCode":"ECO:0000250"}]} |
