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3O4L

Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0002376biological_processimmune system process
A0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
A0005886cellular_componentplasma membrane
A0012507cellular_componentER to Golgi transport vesicle membrane
A0016020cellular_componentmembrane
A0030670cellular_componentphagocytic vesicle membrane
A0031901cellular_componentearly endosome membrane
A0042612cellular_componentMHC class I protein complex
A0055038cellular_componentrecycling endosome membrane
A0098553cellular_componentlumenal side of endoplasmic reticulum membrane
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010038biological_processresponse to metal ion
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0033077biological_processT cell differentiation in thymus
B0033572biological_processtransferrin transport
B0034756biological_processregulation of iron ion transport
B0034757biological_processnegative regulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 277
ChainResidue
AARG35
AHOH336
DLYS148

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 278
ChainResidue
ALYS127
AGLU128
AASP129

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 279
ChainResidue
ATHR142
AHIS145
ALYS146

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 280
ChainResidue
AARG131
AARG219
AARG256
EARG207

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 281
ChainResidue
AGLU232
ATHR233
ALYS243
AHOH295

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MES B 100
ChainResidue
BSER57
BLYS58
BASP59

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 101
ChainResidue
BGLN2
BARG3
BTHR4

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 102
ChainResidue
AARG21
BHIS51
BHOH169

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 103
ChainResidue
BASN17
BGLU74
BARG97

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL D 6
ChainResidue
DSER127
DSER131
DHOH205

site_idBC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL D 202
ChainResidue
CTHR4
DASP27
DSER29
DSER30
DTHR31
DASP93
DASN94
DASN95

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL E 1
ChainResidue
EARG112
ELEU113
ETHR114
EPRO154
EASP155
ETYR190

site_idBC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL E 247
ChainResidue
CTHR4
CLEU5
CVAL6
DTYR34
DASP93
DALA96
EARG98
EGLY102
EASN103
ETYR105

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL E 248
ChainResidue
ESER220
EASN222
EASP223
EHOH345

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL E 249
ChainResidue
EPHE29
EGLN30
EGLY100
EHOH264

site_idBC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL E 250
ChainResidue
ETRP11
EVAL12
EILE13
EHIS156
ETYR217
EGLY218
EHOH272

site_idBC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 E 251
ChainResidue
EGLU167
EVAL168
EHIS169
ESER170
EHOH323
EHOH338

site_idBC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 E 252
ChainResidue
DLYS130
ETHR150
EGLU181

site_idCC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 E 253
ChainResidue
EHIS8
EPRO9
ESER10

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
ATYR257-HIS263
BTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
EASN186
DASN177

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
DASN188

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
BLYS19
BLYS41
BLYS48
BLYS58
BCYS91
BLYS94

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PDB entries from 2025-06-11

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