3NAI
Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 1 |
| Chain | Residue |
| A | ASP245 |
| A | TYR246 |
| A | ASP346 |
| A | URF521 |
| A | HOH529 |
| A | HOH559 |
| A | HOH657 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE URF A 521 |
| Chain | Residue |
| A | ASP245 |
| A | ASP346 |
| A | ASP347 |
| A | ARG395 |
| A | HOH529 |
| A | HOH559 |
| A | MG1 |
| A | ARG185 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN3 A 522 |
| Chain | Residue |
| A | LYS210 |
| A | CYS213 |
| A | GLY221 |
| A | MN3523 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN3 A 523 |
| Chain | Residue |
| A | GLU211 |
| A | CYS213 |
| A | ILE214 |
| A | MN3522 |
| A | HOH539 |
| A | HOH656 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 524 |
| Chain | Residue |
| A | GLY51 |
| A | SER52 |
| A | SER61 |
| A | LEU62 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | PRO82 |
| A | GLN83 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | THR120 |
| A | LYS130 |
| A | MET195 |
| A | GLY304 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 525 |
| Chain | Residue |
| A | TRP134 |
| A | GLY136 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 526 |
| Chain | Residue |
| A | ASN237 |
| A | GLY400 |
| A | ASP401 |
| A | TRP405 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 527 |
| Chain | Residue |
| A | ARG385 |
| A | GLN386 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 528 |
| Chain | Residue |
| A | ARG7 |
| A | PRO8 |
| A | SER9 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 2 |
| Chain | Residue |
| B | ASP245 |
| B | TYR246 |
| B | ASP346 |
| B | URF521 |
| B | HOH581 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE URF B 521 |
| Chain | Residue |
| B | MG2 |
| B | ARG185 |
| B | ASP245 |
| B | ASP346 |
| B | ASP347 |
| B | HOH576 |
| B | HOH635 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN3 B 522 |
| Chain | Residue |
| B | LYS210 |
| B | CYS213 |
| B | GLY221 |
| B | MN3523 |
| B | HOH551 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN3 B 523 |
| Chain | Residue |
| B | CYS213 |
| B | ILE214 |
| B | MN3522 |
| B | HOH554 |
| B | HOH634 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 524 |
| Chain | Residue |
| B | THR28 |
| B | GLY51 |
| B | SER52 |
| B | SER61 |
| B | LEU62 |
| B | HOH577 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 525 |
| Chain | Residue |
| B | ASP117 |
| B | THR120 |
| B | LYS130 |
| B | MET195 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 526 |
| Chain | Residue |
| B | HIS149 |
| B | ASN152 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 527 |
| Chain | Residue |
| B | TYR20 |
| B | ASP292 |
| B | TYR293 |
| C | TYR20 |
| C | ASP292 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 528 |
| Chain | Residue |
| A | THR328 |
| A | GLU355 |
| B | THR328 |
| B | VAL330 |
| B | GLU355 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 3 |
| Chain | Residue |
| C | ASP245 |
| C | TYR246 |
| C | ASP346 |
| C | URF521 |
| C | HOH563 |
| C | HOH632 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE URF C 521 |
| Chain | Residue |
| C | ASP346 |
| C | ASP347 |
| C | ARG395 |
| C | HOH632 |
| C | HOH636 |
| C | HOH638 |
| C | MG3 |
| C | ARG185 |
| C | ASP245 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN3 C 522 |
| Chain | Residue |
| C | LYS210 |
| C | CYS213 |
| C | MN3523 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN3 C 523 |
| Chain | Residue |
| C | GLU211 |
| C | CYS213 |
| C | ILE214 |
| C | MN3522 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 524 |
| Chain | Residue |
| C | GLY51 |
| C | SER52 |
| C | SER61 |
| C | LEU62 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 525 |
| Chain | Residue |
| C | HIS149 |
| C | ASN152 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 526 |
| Chain | Residue |
| C | GLY400 |
| C | ASP401 |
| C | TRP405 |
| C | HOH602 |
| site_id | DC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL C 2 |
| Chain | Residue |
| C | THR11 |
| C | ALA13 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP243 | |
| A | GLU348 | |
| B | ASP243 | |
| B | GLU348 | |
| C | ASP243 | |
| C | GLU348 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315 |
| Chain | Residue | Details |
| A | ASP245 | |
| B | ASP245 | |
| C | ASP245 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP347 | |
| B | ASP347 | |
| C | ASP347 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | SER392 | |
| B | SER392 | |
| C | SER392 |
