3NAI

Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0006351	biological_process	DNA-templated transcription
B	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0004386	molecular_function	helicase activity
C	0005524	molecular_function	ATP binding
C	0006351	biological_process	DNA-templated transcription
C	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 1

Chain	Residue
A	ASP245
A	TYR246
A	ASP346
A	URF521
A	HOH529
A	HOH559
A	HOH657

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE URF A 521

Chain	Residue
A	ASP245
A	ASP346
A	ASP347
A	ARG395
A	HOH529
A	HOH559
A	MG1
A	ARG185

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN3 A 522

Chain	Residue
A	LYS210
A	CYS213
A	GLY221
A	MN3523

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN3 A 523

Chain	Residue
A	GLU211
A	CYS213
A	ILE214
A	MN3522
A	HOH539
A	HOH656

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 524

Chain	Residue
A	GLY51
A	SER52
A	SER61
A	LEU62

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	PRO82
A	GLN83

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	THR120
A	LYS130
A	MET195
A	GLY304

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 525

Chain	Residue
A	TRP134
A	GLY136

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 526

Chain	Residue
A	ASN237
A	GLY400
A	ASP401
A	TRP405

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 527

Chain	Residue
A	ARG385
A	GLN386

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 528

Chain	Residue
A	ARG7
A	PRO8
A	SER9

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 2

Chain	Residue
B	ASP245
B	TYR246
B	ASP346
B	URF521
B	HOH581

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE URF B 521

Chain	Residue
B	MG2
B	ARG185
B	ASP245
B	ASP346
B	ASP347
B	HOH576
B	HOH635

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN3 B 522

Chain	Residue
B	LYS210
B	CYS213
B	GLY221
B	MN3523
B	HOH551

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN3 B 523

Chain	Residue
B	CYS213
B	ILE214
B	MN3522
B	HOH554
B	HOH634

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 524

Chain	Residue
B	THR28
B	GLY51
B	SER52
B	SER61
B	LEU62
B	HOH577

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 525

Chain	Residue
B	ASP117
B	THR120
B	LYS130
B	MET195

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 526

Chain	Residue
B	HIS149
B	ASN152

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 527

Chain	Residue
B	TYR20
B	ASP292
B	TYR293
C	TYR20
C	ASP292

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 528

Chain	Residue
A	THR328
A	GLU355
B	THR328
B	VAL330
B	GLU355

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 3

Chain	Residue
C	ASP245
C	TYR246
C	ASP346
C	URF521
C	HOH563
C	HOH632

---

site_id	CC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE URF C 521

Chain	Residue
C	ASP346
C	ASP347
C	ARG395
C	HOH632
C	HOH636
C	HOH638
C	MG3
C	ARG185
C	ASP245

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN3 C 522

Chain	Residue
C	LYS210
C	CYS213
C	MN3523

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN3 C 523

Chain	Residue
C	GLU211
C	CYS213
C	ILE214
C	MN3522

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 524

Chain	Residue
C	GLY51
C	SER52
C	SER61
C	LEU62

---

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 525

Chain	Residue
C	HIS149
C	ASN152

---

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 526

Chain	Residue
C	GLY400
C	ASP401
C	TRP405
C	HOH602

---

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 2

Chain	Residue
C	THR11
C	ALA13

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	363
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---