3N3Z

Crystal structure of PDE9A (E406A) mutant in complex with IBMX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IBM A 1

Chain	Residue
A	ILE403
A	ASN405
A	LEU420
A	TYR424
A	ALA452
A	GLN453
A	PHE456

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	ASP293
A	ASP402
A	MG508
A	HIS256
A	HIS292

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 508

Chain	Residue
A	HOH89
A	HOH90
A	HOH91
A	HOH92
A	HOH93
A	ASP293
A	ZN507

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	MG1
B	HOH94
B	HIS256
B	HIS292
B	ASP293
B	ASP402

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 1

Chain	Residue
B	ZN2
B	HOH94
B	HOH95
B	HOH96
B	HOH97
B	HOH100
B	ASP293

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IBM B 507

Chain	Residue
B	LEU420
B	TYR424
B	PHE441
B	PHE456

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 508

Chain	Residue
B	ARG487

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGynNtY

Chain	Residue	Details
A	HIS292-TYR303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19919087","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21483814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22985069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23025719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HD1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YY2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DYN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K3H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GH6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8QZV1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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