3K3E
Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691
Summary for 3K3E
Entry DOI | 10.2210/pdb3k3e/pdb |
Related | 3K3H |
Descriptor | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde9, catalytic domain, cgmp, hydrolase, manganese, metal-binding, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform PDE9A1: Cell projection, ruffle membrane. Isoform PDE9A2: Cell projection, ruffle membrane. Isoform PDE9A3: Cytoplasm. Isoform PDE9A17: Cytoplasm: O76083 |
Total number of polymer chains | 2 |
Total formula weight | 77986.03 |
Authors | |
Primary citation | Wang, H.,Luo, X.,Ye, M.,Hou, J.,Robinson, H.,Ke, H. Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis J.Med.Chem., 53:1726-1731, 2010 Cited by PubMed: 20121115DOI: 10.1021/jm901519f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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