3MXM
TREX1 3' Exonuclease V201D Aicardi-Goutieres Syndrome Mutant
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 243 |
| Chain | Residue |
| B | ASP18 |
| B | GLU20 |
| B | ASP200 |
| D | DG4 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IOD B 244 |
| Chain | Residue |
| A | GLN95 |
| A | HOH440 |
| B | PRO61 |
| B | ARG62 |
| B | HOH447 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 245 |
| Chain | Residue |
| B | LYS211 |
| B | GLN213 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 246 |
| Chain | Residue |
| B | PRO25 |
| B | TYR233 |
| B | HOH250 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 243 |
| Chain | Residue |
| A | ASP18 |
| A | GLU20 |
| A | ASP200 |
| C | DG4 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD A 244 |
| Chain | Residue |
| A | ARG62 |
| A | HOH269 |
| B | GLN95 |
| B | HOH517 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 246 |
| Chain | Residue |
| A | LYS211 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 247 |
| Chain | Residue |
| B | SER26 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 248 |
| Chain | Residue |
| A | GLY80 |
| C | DG4 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 249 |
| Chain | Residue |
| A | LEU24 |
| C | DG4 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 250 |
| Chain | Residue |
| A | PRO25 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 251 |
| Chain | Residue |
| A | LYS89 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 5 |
| Chain | Residue |
| A | ASP18 |
| A | HOH255 |
| A | HOH257 |
| C | DC3 |
| C | DG4 |
| C | HOH45 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 5 |
| Chain | Residue |
| B | ASP18 |
| B | HOH252 |
| B | HOH256 |
| D | DC3 |
| D | DG4 |
| D | HOH37 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 12 |
| Chain | Residue |
| A | GLY234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17293595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22071149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9NSU2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
