3MJH

Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GTP A 200

Chain	Residue
A	HOH6
A	HIS46
A	GLU47
A	GLN49
A	SER51
A	THR52
A	GLY78
A	ASN133
A	LYS134
A	ASP136
A	SER163
A	SER29
A	ALA164
A	LYS165
A	HOH196
A	MG201
A	HOH259
A	HOH302
A	HOH306
A	ALA30
A	VAL31
A	GLY32
A	LYS33
A	SER34
A	SER35
A	PHE45

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	SER34
A	THR52
A	GTP200
A	HOH302
A	HOH306

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 70

Chain	Residue
B	CYS43
B	CYS46
B	HIS59
B	HIS64

---

site_id	AC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GTP C 200

Chain	Residue
C	HOH12
C	SER29
C	ALA30
C	VAL31
C	GLY32
C	LYS33
C	SER34
C	SER35
C	PHE45
C	HIS46
C	GLU47
C	GLN49
C	THR52
C	GLY78
C	ASN133
C	LYS134
C	ASP136
C	LEU137
C	SER163
C	ALA164
C	LYS165
C	HOH193
C	MG201
C	HOH272
C	HOH274
C	HOH306

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 201

Chain	Residue
C	SER34
C	THR52
C	GTP200
C	HOH272
C	HOH274

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 70

Chain	Residue
D	CYS43
D	CYS46
D	HIS59
D	HIS64

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	22
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpq..CmksLgsadelfkHyeav.H

Chain	Residue	Details
B	CYS43-HIS64

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12433916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12433916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14684892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"32974215","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	46
Details	Zinc finger: {"description":"C2H2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---