3LIN
crystal structure of HTLV protease complexed with the inhibitor, KNI-10562
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
| H | 0008233 | molecular_function | peptidase activity |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| I | 0006508 | biological_process | proteolysis |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| J | 0006508 | biological_process | proteolysis |
| J | 0008233 | molecular_function | peptidase activity |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| K | 0006508 | biological_process | proteolysis |
| K | 0008233 | molecular_function | peptidase activity |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| L | 0006508 | biological_process | proteolysis |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE E13 B 117 |
| Chain | Residue |
| A | ARG10 |
| B | ASP32 |
| B | GLY34 |
| B | ALA35 |
| B | ASP36 |
| B | MET37 |
| B | VAL56 |
| B | LEU57 |
| B | GLY58 |
| B | ALA59 |
| B | TRP98 |
| A | ASP32 |
| B | HOH123 |
| B | HOH146 |
| B | HOH374 |
| A | GLY34 |
| A | ALA35 |
| A | MET37 |
| A | VAL39 |
| A | LEU57 |
| A | HOH117 |
| B | LEU30 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE E13 C 117 |
| Chain | Residue |
| C | ARG10 |
| C | LEU30 |
| C | ASP32 |
| C | GLY34 |
| C | ALA35 |
| C | ASP36 |
| C | MET37 |
| C | VAL39 |
| C | VAL56 |
| C | LEU57 |
| C | GLY58 |
| C | ALA59 |
| C | TRP98 |
| C | HOH118 |
| C | HOH835 |
| C | HOH836 |
| C | HOH837 |
| C | HOH840 |
| C | HOH841 |
| C | HOH842 |
| C | HOH843 |
| C | HOH844 |
| D | ARG10 |
| D | ASP32 |
| D | GLY34 |
| D | ALA35 |
| D | ASP36 |
| D | MET37 |
| D | VAL56 |
| D | LEU57 |
| D | GLY58 |
| D | ALA59 |
| D | LEU91 |
| D | TRP98 |
| D | HOH571 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE E13 E 117 |
| Chain | Residue |
| E | LEU30 |
| E | ASP32 |
| E | GLY34 |
| E | ALA35 |
| E | ASP36 |
| E | SER55 |
| E | VAL56 |
| E | LEU57 |
| E | GLY58 |
| E | ALA59 |
| E | HOH210 |
| F | ARG10 |
| F | ASP32 |
| F | GLY34 |
| F | ALA35 |
| F | MET37 |
| F | VAL39 |
| F | LEU57 |
| F | ALA59 |
| F | TRP98 |
| F | HOH117 |
| site_id | AC4 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE E13 H 117 |
| Chain | Residue |
| H | LEU57 |
| H | GLY58 |
| H | ALA59 |
| H | LEU91 |
| H | TRP98 |
| H | HOH118 |
| H | HOH529 |
| H | HOH838 |
| H | HOH839 |
| G | ARG10 |
| G | LEU30 |
| G | ASP32 |
| G | GLY34 |
| G | ALA35 |
| G | ASP36 |
| G | MET37 |
| G | VAL56 |
| G | LEU57 |
| G | GLY58 |
| G | ALA59 |
| G | TRP98 |
| G | ILE100 |
| H | ARG10 |
| H | LEU30 |
| H | ASP32 |
| H | GLY34 |
| H | ALA35 |
| H | ASP36 |
| H | VAL39 |
| H | VAL56 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE E13 I 117 |
| Chain | Residue |
| I | ARG10 |
| I | LEU30 |
| I | ASP32 |
| I | GLY34 |
| I | ASP36 |
| I | MET37 |
| I | VAL56 |
| I | LEU57 |
| I | GLY58 |
| I | ALA59 |
| I | LEU91 |
| I | TRP98 |
| J | ARG10 |
| J | LEU30 |
| J | ASP32 |
| J | GLY34 |
| J | ALA35 |
| J | ASP36 |
| J | MET37 |
| J | VAL39 |
| J | VAL56 |
| J | LEU57 |
| J | GLY58 |
| J | ALA59 |
| J | LEU91 |
| J | HOH117 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE E13 L 117 |
| Chain | Residue |
| K | ARG10 |
| K | ASP32 |
| K | GLY34 |
| K | ALA35 |
| K | MET37 |
| K | LEU57 |
| K | ALA59 |
| K | LEU91 |
| K | TRP98 |
| K | HOH124 |
| L | LEU30 |
| L | ASP32 |
| L | GLY34 |
| L | ASP36 |
| L | VAL56 |
| L | LEU57 |
| L | GLY58 |
| L | ALA59 |
| L | TRP98 |
| L | HOH363 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADMTVI |
| Chain | Residue | Details |
| A | ALA29-ILE40 |
