3L5I

Crystal structure of FnIII domains of human GP130 (Domains 4-6)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004896	molecular_function	cytokine receptor activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1

Chain	Residue
A	EDO10
A	HOH53
A	THR366
A	VAL437
A	TYR470
A	HOH612

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 2

Chain	Residue
A	ALA490
A	TYR491
A	GLN494
A	PHE528
A	HOH55
A	HOH112
A	PRO412

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 3

Chain	Residue
A	PHE535
A	ARG537
A	GLU543
A	MSE567
A	VAL568
A	ARG569
A	GLU583

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 4

Chain	Residue
A	HOH51
A	HOH295
A	PHE399
A	ALA401
A	THR402
A	TYR478
A	ASP480
A	PRO482
A	GLY483

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 5

Chain	Residue
A	ARG569
A	TYR573
A	ASP580

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 6

Chain	Residue
A	GLU426
A	VAL428
A	GLY453

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 7

Chain	Residue
A	HOH125
A	HIS403
A	PRO404
A	ASN542
A	THR544

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 8

Chain	Residue
A	GLU434
A	LEU471
A	THR473

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 9

Chain	Residue
A	VAL328
A	GLU434
A	THR446
A	TRP448
A	HOH638

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 10

Chain	Residue
A	EDO1
A	HOH72
A	ASN368
A	TRP435
A	VAL437
A	ILE445
A	ASP447

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 11

Chain	Residue
A	HOH92
A	ILE341
A	ASN361

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 12

Chain	Residue
A	HOH292
A	TRP311
A	TYR312

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 13

Chain	Residue
A	PRO316
A	SER317
A	ALA362
A	THR363

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 591

Chain	Residue
A	LYS510
A	ASN511
A	GLU512

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 14

Chain	Residue
A	MSE416
A	LEU417
A	LEU460
A	GLY462
A	LEU464
A	HOH648

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 592

Chain	Residue
A	ILE488
A	LYS489

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 15

Chain	Residue
A	ARG457
A	GLY509
A	GLU512
A	VAL514
A	THR556

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 16

Chain	Residue
A	THR402
A	SER559
A	LEU560
A	THR561
A	TYR566

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 593

Chain	Residue
A	SER309
A	GLN450
A	ARG461
A	HOH606

---

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 17

Chain	Residue
A	TYR555
A	THR556

---

Functional Information from PROSITE/UniProt

site_id	PS01353
Number of Residues	54
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW

Chain	Residue	Details
A	ASN382-TRP435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	95
Details	Domain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---