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3KUC

Complex of Rap1A(E30D/K31E)GDP with RafRBD(A85K/N71R)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0007399biological_processnervous system development
A0010008cellular_componentendosome membrane
A0010976biological_processpositive regulation of neuron projection development
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030033biological_processmicrovillus assembly
A0030054cellular_componentcell junction
A0031267molecular_functionsmall GTPase binding
A0032045cellular_componentguanyl-nucleotide exchange factor complex
A0032486biological_processRap protein signal transduction
A0035579cellular_componentspecific granule membrane
A0038180biological_processnerve growth factor signaling pathway
A0043005cellular_componentneuron projection
A0043547biological_processpositive regulation of GTPase activity
A0044877molecular_functionprotein-containing complex binding
A0045860biological_processpositive regulation of protein kinase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0061028biological_processestablishment of endothelial barrier
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071320biological_processcellular response to cAMP
A0072659biological_processprotein localization to plasma membrane
A0097225cellular_componentsperm midpiece
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A1901888biological_processregulation of cell junction assembly
A1990090biological_processcellular response to nerve growth factor stimulus
A2000301biological_processnegative regulation of synaptic vesicle exocytosis
A2001214biological_processpositive regulation of vasculogenesis
B0007165biological_processsignal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GDP A 170
ChainResidue
AGLY13
ATYR32
AASN116
ALYS117
AASP119
ALEU120
ASER147
AALA148
ALYS149
AMG171
AHOH202
AVAL14
AHOH204
AHOH206
AHOH227
AHOH231
AHOH237
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29
AASP30

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 171
ChainResidue
ASER17
ATHR35
AGDP170
AHOH202
AHOH204
AHOH231

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 172
ChainResidue
BASP80
BGLY123
BGLU125
BHOH238
BHOH242
BHOH249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:7791872, ECO:0000269|PubMed:8756332
ChainResidueDetails
AGLY10
AVAL29
AGLY60
AASN116

222624

PDB entries from 2024-07-17

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