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3KUC

Complex of Rap1A(E30D/K31E)GDP with RafRBD(A85K/N71R)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007399biological_processnervous system development
A0009743biological_processresponse to carbohydrate
A0010008cellular_componentendosome membrane
A0010976biological_processpositive regulation of neuron projection development
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0030054cellular_componentcell junction
A0030073biological_processinsulin secretion
A0031045cellular_componentdense core granule
A0031267molecular_functionsmall GTPase binding
A0032045cellular_componentguanyl-nucleotide exchange factor complex
A0032486biological_processRap protein signal transduction
A0032966biological_processnegative regulation of collagen biosynthetic process
A0035579cellular_componentspecific granule membrane
A0038180biological_processnerve growth factor signaling pathway
A0043005cellular_componentneuron projection
A0043547biological_processpositive regulation of GTPase activity
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045860biological_processpositive regulation of protein kinase activity
A0046326biological_processpositive regulation of D-glucose import
A0048471cellular_componentperinuclear region of cytoplasm
A0050766biological_processpositive regulation of phagocytosis
A0060369biological_processpositive regulation of Fc receptor mediated stimulatory signaling pathway
A0061028biological_processestablishment of endothelial barrier
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071320biological_processcellular response to cAMP
A0072659biological_processprotein localization to plasma membrane
A0097225cellular_componentsperm midpiece
A0097327biological_processresponse to antineoplastic agent
A0097421biological_processliver regeneration
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A1901888biological_processregulation of cell junction assembly
A1904322biological_processcellular response to forskolin
A1990090biological_processcellular response to nerve growth factor stimulus
A2000301biological_processnegative regulation of synaptic vesicle exocytosis
A2001214biological_processpositive regulation of vasculogenesis
B0007165biological_processsignal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GDP A 170
ChainResidue
AGLY13
ATYR32
AASN116
ALYS117
AASP119
ALEU120
ASER147
AALA148
ALYS149
AMG171
AHOH202
AVAL14
AHOH204
AHOH206
AHOH227
AHOH231
AHOH237
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29
AASP30

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 171
ChainResidue
ASER17
ATHR35
AGDP170
AHOH202
AHOH204
AHOH231

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 172
ChainResidue
BASP80
BGLY123
BGLU125
BHOH238
BHOH242
BHOH249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7791872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8756332","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues75
DetailsDomain: {"description":"RBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00262","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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