3KHJ
C. parvum inosine monophosphate dehydrogenase bound by inhibitor C64
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003938 | molecular_function | IMP dehydrogenase activity |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003938 | molecular_function | IMP dehydrogenase activity |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003938 | molecular_function | IMP dehydrogenase activity |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003938 | molecular_function | IMP dehydrogenase activity |
| E | 0006164 | biological_process | purine nucleotide biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003938 | molecular_function | IMP dehydrogenase activity |
| F | 0006164 | biological_process | purine nucleotide biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0003938 | molecular_function | IMP dehydrogenase activity |
| G | 0006164 | biological_process | purine nucleotide biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003938 | molecular_function | IMP dehydrogenase activity |
| H | 0006164 | biological_process | purine nucleotide biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE IMP A 801 |
| Chain | Residue |
| A | SER48 |
| A | GLY275 |
| A | SER276 |
| A | HOH401 |
| A | HOH409 |
| A | MET50 |
| A | GLY216 |
| A | SER217 |
| A | ILE218 |
| A | ASP252 |
| A | GLY253 |
| A | GLY254 |
| A | MET273 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE IMP B 804 |
| Chain | Residue |
| B | SER48 |
| B | MET50 |
| B | GLY216 |
| B | SER217 |
| B | ILE218 |
| B | CYS219 |
| B | ASP252 |
| B | GLY253 |
| B | GLY254 |
| B | GLY275 |
| B | SER276 |
| B | TYR299 |
| B | GLY301 |
| B | MET302 |
| B | GLY303 |
| B | GLU329 |
| B | GLY330 |
| B | HOH406 |
| B | HOH414 |
| B | HOH419 |
| B | C64901 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE C64 B 901 |
| Chain | Residue |
| A | SER354 |
| A | GLY357 |
| A | TYR358 |
| B | ALA165 |
| B | MET302 |
| B | GLY303 |
| B | GLU329 |
| B | IMP804 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE IMP C 803 |
| Chain | Residue |
| C | SER48 |
| C | MET50 |
| C | GLY216 |
| C | SER217 |
| C | ILE218 |
| C | CYS219 |
| C | ASP252 |
| C | GLY253 |
| C | GLY254 |
| C | MET273 |
| C | GLY275 |
| C | SER276 |
| C | TYR299 |
| C | HOH401 |
| C | HOH408 |
| C | HOH431 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE IMP D 802 |
| Chain | Residue |
| D | SER48 |
| D | MET50 |
| D | GLY216 |
| D | SER217 |
| D | ILE218 |
| D | CYS219 |
| D | ASP252 |
| D | GLY253 |
| D | GLY254 |
| D | MET273 |
| D | GLY275 |
| D | SER276 |
| D | TYR299 |
| D | GLY301 |
| D | MET302 |
| D | GLY303 |
| D | GLU329 |
| D | GLY330 |
| D | HOH408 |
| D | HOH410 |
| D | HOH430 |
| D | C64902 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D 401 |
| Chain | Residue |
| D | GLU287 |
| D | LYS297 |
| D | TYR298 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE C64 D 902 |
| Chain | Residue |
| C | SER354 |
| C | GLY357 |
| C | TYR358 |
| D | ALA165 |
| D | MET302 |
| D | GLY303 |
| D | MET308 |
| D | MET326 |
| D | GLU329 |
| D | IMP802 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE IMP E 805 |
| Chain | Residue |
| E | GLY275 |
| E | SER276 |
| E | SER48 |
| E | THR220 |
| E | THR221 |
| E | ASP252 |
| E | GLY253 |
| E | GLY254 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IMP F 808 |
| Chain | Residue |
| F | SER48 |
| F | MET50 |
| F | HOH111 |
| F | GLY216 |
| F | SER217 |
| F | ASP252 |
| F | GLY253 |
| F | GLY254 |
| F | MET273 |
| F | ILE274 |
| F | GLY275 |
| F | SER276 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IMP G 807 |
| Chain | Residue |
| G | SER48 |
| G | SER164 |
| G | ALA165 |
| G | ASN191 |
| G | GLY216 |
| G | ASP252 |
| G | GLY254 |
| G | ILE255 |
| G | GLY275 |
| G | SER276 |
| site_id | BC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE IMP H 806 |
| Chain | Residue |
| H | SER48 |
| H | MET50 |
| H | GLY216 |
| H | SER217 |
| H | ILE218 |
| H | CYS219 |
| H | ASP252 |
| H | GLY253 |
| H | GLY254 |
| H | GLY275 |
| H | SER276 |
| H | TYR299 |
| H | GLY301 |
| H | MET302 |
| H | GLY303 |
| H | GLU329 |
| H | GLY330 |
| H | HOH410 |
| H | C64903 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE C64 H 903 |
| Chain | Residue |
| G | PRO26 |
| G | GLY357 |
| G | TYR358 |
| H | ALA165 |
| H | HIS166 |
| H | MET302 |
| H | GLY303 |
| H | MET308 |
| H | MET326 |
| H | GLU329 |
| H | IMP806 |
Functional Information from PROSITE/UniProt
| site_id | PS00487 |
| Number of Residues | 13 |
| Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKVGIGpGSICtT |
| Chain | Residue | Details |
| A | ILE209-THR221 |
