Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3K8Y

Allosteric modulation of H-Ras GTPase

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues31
DetailsBINDING SITE FOR RESIDUE GNP A 528
ChainResidue
AGLY12
AASP30
AGLU31
APRO34
ATHR35
AGLY60
AASN116
ALYS117
AASP119
ALEU120
ASER145
AGLY13
AALA146
ALYS147
AMG168
AHOH171
AHOH172
AHOH173
AHOH175
AHOH184
AHOH189
AHOH198
AVAL14
AHOH209
AHOH288
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 167
ChainResidue
APHE28
AASP30
AGLU31
AASP33
AHOH200
AHOH233

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 168
ChainResidue
ASER17
ATHR35
AHOH172
AHOH173
AGNP528

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 169
ChainResidue
AASP107
ATYR137
AHOH232
AHOH366
AHOH392
AACT719

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 170
ChainResidue
AHOH178
AHOH178
AHOH178
AHOH182
AHOH182
AHOH182

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ACT A 719
ChainResidue
AARG97
ALYS101
AASP107
AASP108
AVAL109
AMET111
ACA169
AHOH232

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:16698776
ChainResidueDetails
AGLY13
AVAL29
AALA59
AASN116
ASER145

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12
ChainResidueDetails
AMET1

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12
ChainResidueDetails
ATHR2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151
ChainResidueDetails
ACYS118

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667
ChainResidueDetails
ATHR35

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon