3JCM

Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000243	cellular_component	commitment complex
a	0000245	biological_process	spliceosomal complex assembly
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000395	biological_process	mRNA 5'-splice site recognition
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003674	molecular_function	molecular_function
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005737	cellular_component	cytoplasm
a	0006397	biological_process	mRNA processing
a	0008150	biological_process	biological_process
a	0008380	biological_process	RNA splicing
a	0032991	cellular_component	protein-containing complex
a	0034719	cellular_component	SMN-Sm protein complex
a	0036261	biological_process	7-methylguanosine cap hypermethylation
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0071001	cellular_component	U4/U6 snRNP
a	0071004	cellular_component	U2-type prespliceosome
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	0097526	cellular_component	spliceosomal tri-snRNP complex
a	1903241	biological_process	U2-type prespliceosome assembly
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
A	0000386	molecular_function	second spliceosomal transesterification activity
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000389	biological_process	mRNA 3'-splice site recognition
A	0000395	biological_process	mRNA 5'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0003729	molecular_function	mRNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005681	cellular_component	spliceosomal complex
b	0005688	cellular_component	U6 snRNP
b	0005730	cellular_component	nucleolus
b	0005737	cellular_component	cytoplasm
b	0006364	biological_process	rRNA processing
b	0006397	biological_process	mRNA processing
b	0008033	biological_process	tRNA processing
b	0008380	biological_process	RNA splicing
b	0032991	cellular_component	protein-containing complex
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071001	cellular_component	U4/U6 snRNP
b	0071011	cellular_component	precatalytic spliceosome
B	0000245	biological_process	spliceosomal complex assembly
B	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005687	cellular_component	U4 snRNP
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0017070	molecular_function	U6 snRNA binding
B	0030621	molecular_function	U4 snRNA binding
B	0034247	biological_process	snoRNA splicing
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0071001	cellular_component	U4/U6 snRNP
c	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0000932	cellular_component	P-body
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005681	cellular_component	spliceosomal complex
c	0005688	cellular_component	U6 snRNP
c	0005730	cellular_component	nucleolus
c	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
c	0005737	cellular_component	cytoplasm
c	0006364	biological_process	rRNA processing
c	0006397	biological_process	mRNA processing
c	0008033	biological_process	tRNA processing
c	0008380	biological_process	RNA splicing
c	0032991	cellular_component	protein-containing complex
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0071001	cellular_component	U4/U6 snRNP
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	1990726	cellular_component	Lsm1-7-Pat1 complex
d	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0000932	cellular_component	P-body
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005688	cellular_component	U6 snRNP
d	0005730	cellular_component	nucleolus
d	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
d	0005737	cellular_component	cytoplasm
d	0006364	biological_process	rRNA processing
d	0006397	biological_process	mRNA processing
d	0008033	biological_process	tRNA processing
d	0008380	biological_process	RNA splicing
d	0032991	cellular_component	protein-containing complex
d	0033962	biological_process	P-body assembly
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071001	cellular_component	U4/U6 snRNP
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	1990726	cellular_component	Lsm1-7-Pat1 complex
e	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0000932	cellular_component	P-body
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005688	cellular_component	U6 snRNP
e	0005730	cellular_component	nucleolus
e	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
e	0005737	cellular_component	cytoplasm
e	0006364	biological_process	rRNA processing
e	0006397	biological_process	mRNA processing
e	0008033	biological_process	tRNA processing
e	0008380	biological_process	RNA splicing
e	0030490	biological_process	maturation of SSU-rRNA
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071001	cellular_component	U4/U6 snRNP
e	0120114	cellular_component	Sm-like protein family complex
e	1990726	cellular_component	Lsm1-7-Pat1 complex
f	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0000932	cellular_component	P-body
f	0000956	biological_process	nuclear-transcribed mRNA catabolic process
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005688	cellular_component	U6 snRNP
f	0005730	cellular_component	nucleolus
f	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
f	0006364	biological_process	rRNA processing
f	0006397	biological_process	mRNA processing
f	0008033	biological_process	tRNA processing
f	0008380	biological_process	RNA splicing
f	0032991	cellular_component	protein-containing complex
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071001	cellular_component	U4/U6 snRNP
f	1990726	cellular_component	Lsm1-7-Pat1 complex
g	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0000932	cellular_component	P-body
g	0000956	biological_process	nuclear-transcribed mRNA catabolic process
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005688	cellular_component	U6 snRNP
g	0005730	cellular_component	nucleolus
g	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
g	0005737	cellular_component	cytoplasm
g	0006364	biological_process	rRNA processing
g	0006397	biological_process	mRNA processing
g	0008033	biological_process	tRNA processing
g	0008380	biological_process	RNA splicing
g	0030490	biological_process	maturation of SSU-rRNA
g	0032991	cellular_component	protein-containing complex
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071001	cellular_component	U4/U6 snRNP
g	0071004	cellular_component	U2-type prespliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1990726	cellular_component	Lsm1-7-Pat1 complex
G	0000244	biological_process	spliceosomal tri-snRNP complex assembly
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003674	molecular_function	molecular_function
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005681	cellular_component	spliceosomal complex
G	0005682	cellular_component	U5 snRNP
G	0006396	biological_process	RNA processing
G	0006397	biological_process	mRNA processing
G	0008150	biological_process	biological_process
G	0008380	biological_process	RNA splicing
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0071001	cellular_component	U4/U6 snRNP
G	0071013	cellular_component	catalytic step 2 spliceosome
h	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0000932	cellular_component	P-body
h	0000956	biological_process	nuclear-transcribed mRNA catabolic process
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005681	cellular_component	spliceosomal complex
h	0005688	cellular_component	U6 snRNP
h	0005730	cellular_component	nucleolus
h	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
h	0005737	cellular_component	cytoplasm
h	0006364	biological_process	rRNA processing
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0008033	biological_process	tRNA processing
h	0008380	biological_process	RNA splicing
h	0017070	molecular_function	U6 snRNA binding
h	0033962	biological_process	P-body assembly
h	0042149	biological_process	cellular response to glucose starvation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0071001	cellular_component	U4/U6 snRNP
h	0097525	cellular_component	spliceosomal snRNP complex
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1990726	cellular_component	Lsm1-7-Pat1 complex
H	0000244	biological_process	spliceosomal tri-snRNP complex assembly
H	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
H	0000387	biological_process	spliceosomal snRNP assembly
H	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003924	molecular_function	GTPase activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005681	cellular_component	spliceosomal complex
H	0005682	cellular_component	U5 snRNP
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0030623	molecular_function	U5 snRNA binding
H	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
H	0071007	cellular_component	U2-type catalytic step 2 spliceosome
I	0000244	biological_process	spliceosomal tri-snRNP complex assembly
I	0000387	biological_process	spliceosomal snRNP assembly
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003674	molecular_function	molecular_function
I	0003723	molecular_function	RNA binding
I	0005634	cellular_component	nucleus
I	0005681	cellular_component	spliceosomal complex
I	0005687	cellular_component	U4 snRNP
I	0005739	cellular_component	mitochondrion
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
I	0071001	cellular_component	U4/U6 snRNP
I	0071011	cellular_component	precatalytic spliceosome
I	0097526	cellular_component	spliceosomal tri-snRNP complex
J	0000243	cellular_component	commitment complex
J	0000245	biological_process	spliceosomal complex assembly
J	0000387	biological_process	spliceosomal snRNP assembly
J	0000395	biological_process	mRNA 5'-splice site recognition
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003723	molecular_function	RNA binding
J	0003729	molecular_function	mRNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0005682	cellular_component	U5 snRNP
J	0005685	cellular_component	U1 snRNP
J	0005686	cellular_component	U2 snRNP
J	0005687	cellular_component	U4 snRNP
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006396	biological_process	RNA processing
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0034715	cellular_component	pICln-Sm protein complex
J	0034719	cellular_component	SMN-Sm protein complex
J	0036261	biological_process	7-methylguanosine cap hypermethylation
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0071001	cellular_component	U4/U6 snRNP
J	0071004	cellular_component	U2-type prespliceosome
J	0071011	cellular_component	precatalytic spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
J	0097525	cellular_component	spliceosomal snRNP complex
J	0097526	cellular_component	spliceosomal tri-snRNP complex
J	1903241	biological_process	U2-type prespliceosome assembly
J	1990904	cellular_component	ribonucleoprotein complex
K	0000245	biological_process	spliceosomal complex assembly
K	0000387	biological_process	spliceosomal snRNP assembly
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0003674	molecular_function	molecular_function
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005681	cellular_component	spliceosomal complex
K	0005687	cellular_component	U4 snRNP
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
K	0071001	cellular_component	U4/U6 snRNP
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003674	molecular_function	molecular_function
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0005682	cellular_component	U5 snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0000245	biological_process	spliceosomal complex assembly
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000452	biological_process	snoRNA guided rRNA 2'-O-methylation
M	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0005687	cellular_component	U4 snRNP
M	0005730	cellular_component	nucleolus
M	0006364	biological_process	rRNA processing
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0030490	biological_process	maturation of SSU-rRNA
M	0030621	molecular_function	U4 snRNA binding
M	0031428	cellular_component	box C/D methylation guide snoRNP complex
M	0032040	cellular_component	small-subunit processome
M	0034511	molecular_function	U3 snoRNA binding
M	0042254	biological_process	ribosome biogenesis
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0071001	cellular_component	U4/U6 snRNP
M	0071011	cellular_component	precatalytic spliceosome
M	1990904	cellular_component	ribonucleoprotein complex
N	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0003676	molecular_function	nucleic acid binding
N	0003724	molecular_function	RNA helicase activity
N	0004386	molecular_function	helicase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0005682	cellular_component	U5 snRNP
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0042802	molecular_function	identical protein binding
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0000243	cellular_component	commitment complex
O	0000245	biological_process	spliceosomal complex assembly
O	0000387	biological_process	spliceosomal snRNP assembly
O	0000395	biological_process	mRNA 5'-splice site recognition
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0003674	molecular_function	molecular_function
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005682	cellular_component	U5 snRNP
O	0005685	cellular_component	U1 snRNP
O	0005686	cellular_component	U2 snRNP
O	0005687	cellular_component	U4 snRNP
O	0005737	cellular_component	cytoplasm
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0032991	cellular_component	protein-containing complex
O	0036261	biological_process	7-methylguanosine cap hypermethylation
O	0043229	cellular_component	intracellular organelle
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0070990	molecular_function	snRNP binding
O	0071001	cellular_component	U4/U6 snRNP
O	0071004	cellular_component	U2-type prespliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	1903241	biological_process	U2-type prespliceosome assembly
O	1990904	cellular_component	ribonucleoprotein complex
P	0000243	cellular_component	commitment complex
P	0000245	biological_process	spliceosomal complex assembly
P	0000387	biological_process	spliceosomal snRNP assembly
P	0000395	biological_process	mRNA 5'-splice site recognition
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003723	molecular_function	RNA binding
P	0003729	molecular_function	mRNA binding
P	0005634	cellular_component	nucleus
P	0005681	cellular_component	spliceosomal complex
P	0005682	cellular_component	U5 snRNP
P	0005685	cellular_component	U1 snRNP
P	0005686	cellular_component	U2 snRNP
P	0005687	cellular_component	U4 snRNP
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006396	biological_process	RNA processing
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0030532	cellular_component	small nuclear ribonucleoprotein complex
P	0034715	cellular_component	pICln-Sm protein complex
P	0034719	cellular_component	SMN-Sm protein complex
P	0036261	biological_process	7-methylguanosine cap hypermethylation
P	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
P	0071001	cellular_component	U4/U6 snRNP
P	0071004	cellular_component	U2-type prespliceosome
P	0071011	cellular_component	precatalytic spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0097525	cellular_component	spliceosomal snRNP complex
P	0097526	cellular_component	spliceosomal tri-snRNP complex
P	1903241	biological_process	U2-type prespliceosome assembly
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000243	cellular_component	commitment complex
Q	0000245	biological_process	spliceosomal complex assembly
Q	0000387	biological_process	spliceosomal snRNP assembly
Q	0000395	biological_process	mRNA 5'-splice site recognition
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003674	molecular_function	molecular_function
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005681	cellular_component	spliceosomal complex
Q	0005682	cellular_component	U5 snRNP
Q	0005685	cellular_component	U1 snRNP
Q	0005686	cellular_component	U2 snRNP
Q	0005687	cellular_component	U4 snRNP
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006397	biological_process	mRNA processing
Q	0008150	biological_process	biological_process
Q	0008380	biological_process	RNA splicing
Q	0030532	cellular_component	small nuclear ribonucleoprotein complex
Q	0032991	cellular_component	protein-containing complex
Q	0034715	cellular_component	pICln-Sm protein complex
Q	0036261	biological_process	7-methylguanosine cap hypermethylation
Q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Q	0071001	cellular_component	U4/U6 snRNP
Q	0071004	cellular_component	U2-type prespliceosome
Q	0071011	cellular_component	precatalytic spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
Q	1903241	biological_process	U2-type prespliceosome assembly
Q	1990904	cellular_component	ribonucleoprotein complex
R	0000243	cellular_component	commitment complex
R	0000245	biological_process	spliceosomal complex assembly
R	0000387	biological_process	spliceosomal snRNP assembly
R	0000395	biological_process	mRNA 5'-splice site recognition
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003723	molecular_function	RNA binding
R	0003729	molecular_function	mRNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005681	cellular_component	spliceosomal complex
R	0005682	cellular_component	U5 snRNP
R	0005685	cellular_component	U1 snRNP
R	0005686	cellular_component	U2 snRNP
R	0005687	cellular_component	U4 snRNP
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006396	biological_process	RNA processing
R	0006397	biological_process	mRNA processing
R	0008380	biological_process	RNA splicing
R	0034715	cellular_component	pICln-Sm protein complex
R	0034719	cellular_component	SMN-Sm protein complex
R	0036261	biological_process	7-methylguanosine cap hypermethylation
R	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
R	0071001	cellular_component	U4/U6 snRNP
R	0071004	cellular_component	U2-type prespliceosome
R	0071011	cellular_component	precatalytic spliceosome
R	0071013	cellular_component	catalytic step 2 spliceosome
R	0097525	cellular_component	spliceosomal snRNP complex
R	0097526	cellular_component	spliceosomal tri-snRNP complex
R	1903241	biological_process	U2-type prespliceosome assembly
R	1990904	cellular_component	ribonucleoprotein complex
S	0000243	cellular_component	commitment complex
S	0000245	biological_process	spliceosomal complex assembly
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000395	biological_process	mRNA 5'-splice site recognition
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003674	molecular_function	molecular_function
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005681	cellular_component	spliceosomal complex
S	0005682	cellular_component	U5 snRNP
S	0005685	cellular_component	U1 snRNP
S	0005686	cellular_component	U2 snRNP
S	0005687	cellular_component	U4 snRNP
S	0005737	cellular_component	cytoplasm
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0032991	cellular_component	protein-containing complex
S	0036261	biological_process	7-methylguanosine cap hypermethylation
S	0043229	cellular_component	intracellular organelle
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0070990	molecular_function	snRNP binding
S	0071001	cellular_component	U4/U6 snRNP
S	0071004	cellular_component	U2-type prespliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
S	1903241	biological_process	U2-type prespliceosome assembly
S	1990904	cellular_component	ribonucleoprotein complex
T	0000243	cellular_component	commitment complex
T	0000245	biological_process	spliceosomal complex assembly
T	0000387	biological_process	spliceosomal snRNP assembly
T	0000395	biological_process	mRNA 5'-splice site recognition
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0003723	molecular_function	RNA binding
T	0003729	molecular_function	mRNA binding
T	0005634	cellular_component	nucleus
T	0005681	cellular_component	spliceosomal complex
T	0005682	cellular_component	U5 snRNP
T	0005685	cellular_component	U1 snRNP
T	0005686	cellular_component	U2 snRNP
T	0005687	cellular_component	U4 snRNP
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006396	biological_process	RNA processing
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0030532	cellular_component	small nuclear ribonucleoprotein complex
T	0034715	cellular_component	pICln-Sm protein complex
T	0034719	cellular_component	SMN-Sm protein complex
T	0036261	biological_process	7-methylguanosine cap hypermethylation
T	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
T	0071001	cellular_component	U4/U6 snRNP
T	0071004	cellular_component	U2-type prespliceosome
T	0071011	cellular_component	precatalytic spliceosome
T	0071013	cellular_component	catalytic step 2 spliceosome
T	0097525	cellular_component	spliceosomal snRNP complex
T	0097526	cellular_component	spliceosomal tri-snRNP complex
T	1903241	biological_process	U2-type prespliceosome assembly
T	1990904	cellular_component	ribonucleoprotein complex
U	0000243	cellular_component	commitment complex
U	0000245	biological_process	spliceosomal complex assembly
U	0000387	biological_process	spliceosomal snRNP assembly
U	0000395	biological_process	mRNA 5'-splice site recognition
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0003674	molecular_function	molecular_function
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005681	cellular_component	spliceosomal complex
U	0005682	cellular_component	U5 snRNP
U	0005685	cellular_component	U1 snRNP
U	0005686	cellular_component	U2 snRNP
U	0005687	cellular_component	U4 snRNP
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006397	biological_process	mRNA processing
U	0008150	biological_process	biological_process
U	0008380	biological_process	RNA splicing
U	0030532	cellular_component	small nuclear ribonucleoprotein complex
U	0032991	cellular_component	protein-containing complex
U	0034715	cellular_component	pICln-Sm protein complex
U	0036261	biological_process	7-methylguanosine cap hypermethylation
U	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
U	0071001	cellular_component	U4/U6 snRNP
U	0071004	cellular_component	U2-type prespliceosome
U	0071011	cellular_component	precatalytic spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
U	1903241	biological_process	U2-type prespliceosome assembly
U	1990904	cellular_component	ribonucleoprotein complex
V	0000243	cellular_component	commitment complex
V	0000245	biological_process	spliceosomal complex assembly
V	0000387	biological_process	spliceosomal snRNP assembly
V	0000395	biological_process	mRNA 5'-splice site recognition
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005681	cellular_component	spliceosomal complex
V	0005682	cellular_component	U5 snRNP
V	0005685	cellular_component	U1 snRNP
V	0005686	cellular_component	U2 snRNP
V	0005687	cellular_component	U4 snRNP
V	0005737	cellular_component	cytoplasm
V	0006397	biological_process	mRNA processing
V	0008380	biological_process	RNA splicing
V	0032991	cellular_component	protein-containing complex
V	0034715	cellular_component	pICln-Sm protein complex
V	0036261	biological_process	7-methylguanosine cap hypermethylation
V	0043229	cellular_component	intracellular organelle
V	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
V	0071001	cellular_component	U4/U6 snRNP
V	0071004	cellular_component	U2-type prespliceosome
V	0071011	cellular_component	precatalytic spliceosome
V	1903241	biological_process	U2-type prespliceosome assembly
V	1990935	molecular_function	splicing factor binding
W	0000243	cellular_component	commitment complex
W	0000245	biological_process	spliceosomal complex assembly
W	0000387	biological_process	spliceosomal snRNP assembly
W	0000395	biological_process	mRNA 5'-splice site recognition
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005681	cellular_component	spliceosomal complex
W	0005682	cellular_component	U5 snRNP
W	0005685	cellular_component	U1 snRNP
W	0005686	cellular_component	U2 snRNP
W	0005687	cellular_component	U4 snRNP
W	0005737	cellular_component	cytoplasm
W	0006397	biological_process	mRNA processing
W	0008266	molecular_function	poly(U) RNA binding
W	0008380	biological_process	RNA splicing
W	0034715	cellular_component	pICln-Sm protein complex
W	0036261	biological_process	7-methylguanosine cap hypermethylation
W	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
W	0071001	cellular_component	U4/U6 snRNP
W	0071013	cellular_component	catalytic step 2 spliceosome
W	0120114	cellular_component	Sm-like protein family complex
W	1903241	biological_process	U2-type prespliceosome assembly
W	1990935	molecular_function	splicing factor binding
X	0000243	cellular_component	commitment complex
X	0000245	biological_process	spliceosomal complex assembly
X	0000387	biological_process	spliceosomal snRNP assembly
X	0000395	biological_process	mRNA 5'-splice site recognition
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0003674	molecular_function	molecular_function
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005681	cellular_component	spliceosomal complex
X	0005682	cellular_component	U5 snRNP
X	0005685	cellular_component	U1 snRNP
X	0005686	cellular_component	U2 snRNP
X	0005687	cellular_component	U4 snRNP
X	0005737	cellular_component	cytoplasm
X	0006397	biological_process	mRNA processing
X	0008150	biological_process	biological_process
X	0008380	biological_process	RNA splicing
X	0032991	cellular_component	protein-containing complex
X	0034719	cellular_component	SMN-Sm protein complex
X	0036261	biological_process	7-methylguanosine cap hypermethylation
X	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
X	0071001	cellular_component	U4/U6 snRNP
X	0071004	cellular_component	U2-type prespliceosome
X	0071011	cellular_component	precatalytic spliceosome
X	0071013	cellular_component	catalytic step 2 spliceosome
X	0097526	cellular_component	spliceosomal tri-snRNP complex
X	1903241	biological_process	U2-type prespliceosome assembly
Y	0000243	cellular_component	commitment complex
Y	0000245	biological_process	spliceosomal complex assembly
Y	0000387	biological_process	spliceosomal snRNP assembly
Y	0000395	biological_process	mRNA 5'-splice site recognition
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0003723	molecular_function	RNA binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005681	cellular_component	spliceosomal complex
Y	0005682	cellular_component	U5 snRNP
Y	0005685	cellular_component	U1 snRNP
Y	0005686	cellular_component	U2 snRNP
Y	0005687	cellular_component	U4 snRNP
Y	0005737	cellular_component	cytoplasm
Y	0006397	biological_process	mRNA processing
Y	0008380	biological_process	RNA splicing
Y	0032991	cellular_component	protein-containing complex
Y	0034715	cellular_component	pICln-Sm protein complex
Y	0036261	biological_process	7-methylguanosine cap hypermethylation
Y	0043229	cellular_component	intracellular organelle
Y	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Y	0071001	cellular_component	U4/U6 snRNP
Y	0071004	cellular_component	U2-type prespliceosome
Y	0071011	cellular_component	precatalytic spliceosome
Y	1903241	biological_process	U2-type prespliceosome assembly
Y	1990935	molecular_function	splicing factor binding
Z	0000243	cellular_component	commitment complex
Z	0000245	biological_process	spliceosomal complex assembly
Z	0000387	biological_process	spliceosomal snRNP assembly
Z	0000395	biological_process	mRNA 5'-splice site recognition
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0003723	molecular_function	RNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005681	cellular_component	spliceosomal complex
Z	0005682	cellular_component	U5 snRNP
Z	0005685	cellular_component	U1 snRNP
Z	0005686	cellular_component	U2 snRNP
Z	0005687	cellular_component	U4 snRNP
Z	0005737	cellular_component	cytoplasm
Z	0006397	biological_process	mRNA processing
Z	0008266	molecular_function	poly(U) RNA binding
Z	0008380	biological_process	RNA splicing
Z	0034715	cellular_component	pICln-Sm protein complex
Z	0036261	biological_process	7-methylguanosine cap hypermethylation
Z	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Z	0071001	cellular_component	U4/U6 snRNP
Z	0071013	cellular_component	catalytic step 2 spliceosome
Z	0120114	cellular_component	Sm-like protein family complex
Z	1903241	biological_process	U2-type prespliceosome assembly
Z	1990935	molecular_function	splicing factor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GTP H 1500

Chain	Residue
A	PRO406
H	SER190
H	LYS269
H	ASP271
H	SER315
H	THR316
H	LYS317
H	HIS143
H	SER144
H	GLY145
H	LYS146
H	THR147
H	SER148
H	ARG176
H	LEU189

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE M7M E 201

Chain	Residue
D	U80
D	G81
D	A82
E	A1
K	GLU362
K	LEU363

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. GINIDSLKFNELVKLM

Chain	Residue	Details
N	GLY174-MET189

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IGSAshDmTWRLWDA

Chain	Residue	Details
B	ILE280-ALA294
B	VAL322-ILE336
B	VAL364-ILE378

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVpSRvaLG

Chain	Residue	Details
M	CYS71-GLY88

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269|PubMed:26046779

Chain	Residue	Details
h	ARG119
N	SER1370
H	ASN268

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:33856219

Chain	Residue	Details
h	SER181

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
H	THR88

---