3JBQ
Domain Organization and Conformational Plasticity of the G Protein Effector, PDE6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007601 | biological_process | visual perception |
| D | 0030553 | molecular_function | cGMP binding |
| F | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| F | 0007165 | biological_process | signal transduction |
| F | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| X | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| X | 0007601 | biological_process | visual perception |
| X | 0030553 | molecular_function | cGMP binding |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY |
| Chain | Residue | Details |
| B | HIS653-TYR664 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR90-HIS96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O76074","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q922S4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 298 |
| Details | Domain: {"description":"GAF 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18614542","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
