3JB9

Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003676	molecular_function	nucleic acid binding
a	0003723	molecular_function	RNA binding
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000974	cellular_component	Prp19 complex
A	0003723	molecular_function	RNA binding
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071014	cellular_component	post-mRNA release spliceosomal complex
A	0097157	molecular_function	pre-mRNA intronic binding
b	0000395	biological_process	mRNA 5'-splice site recognition
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005634	cellular_component	nucleus
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0045292	biological_process	mRNA cis splicing, via spliceosome
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0070990	molecular_function	snRNP binding
b	0071004	cellular_component	U2-type prespliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0071014	cellular_component	post-mRNA release spliceosomal complex
b	0120114	cellular_component	Sm-like protein family complex
b	1990904	cellular_component	ribonucleoprotein complex
B	0000166	molecular_function	nucleotide binding
B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0000974	cellular_component	Prp19 complex
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0005721	cellular_component	pericentric heterochromatin
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0030623	molecular_function	U5 snRNA binding
B	0031047	biological_process	regulatory ncRNA-mediated gene silencing
B	0045292	biological_process	mRNA cis splicing, via spliceosome
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0071014	cellular_component	post-mRNA release spliceosomal complex
B	0140727	biological_process	siRNA-mediated pericentric heterochromatin formation
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0000974	cellular_component	Prp19 complex
c	0003674	molecular_function	molecular_function
c	0005634	cellular_component	nucleus
c	0005681	cellular_component	spliceosomal complex
c	0005684	cellular_component	U2-type spliceosomal complex
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0045292	biological_process	mRNA cis splicing, via spliceosome
c	0071014	cellular_component	post-mRNA release spliceosomal complex
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0000413	biological_process	protein peptidyl-prolyl isomerization
d	0000974	cellular_component	Prp19 complex
d	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005829	cellular_component	cytosol
d	0006457	biological_process	protein folding
d	0016853	molecular_function	isomerase activity
d	0045292	biological_process	mRNA cis splicing, via spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0071014	cellular_component	post-mRNA release spliceosomal complex
D	0000243	cellular_component	commitment complex
D	0000387	biological_process	spliceosomal snRNP assembly
D	0000395	biological_process	mRNA 5'-splice site recognition
D	0003723	molecular_function	RNA binding
D	0003729	molecular_function	mRNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0005685	cellular_component	U1 snRNP
D	0005686	cellular_component	U2 snRNP
D	0005687	cellular_component	U4 snRNP
D	0005829	cellular_component	cytosol
D	0006396	biological_process	RNA processing
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0034719	cellular_component	SMN-Sm protein complex
D	0045292	biological_process	mRNA cis splicing, via spliceosome
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
D	0071004	cellular_component	U2-type prespliceosome
D	0071011	cellular_component	precatalytic spliceosome
D	0071013	cellular_component	catalytic step 2 spliceosome
D	0071014	cellular_component	post-mRNA release spliceosomal complex
D	0097526	cellular_component	spliceosomal tri-snRNP complex
D	1990904	cellular_component	ribonucleoprotein complex
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0000974	cellular_component	Prp19 complex
e	0003674	molecular_function	molecular_function
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005684	cellular_component	U2-type spliceosomal complex
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0045292	biological_process	mRNA cis splicing, via spliceosome
e	0071014	cellular_component	post-mRNA release spliceosomal complex
E	0000395	biological_process	mRNA 5'-splice site recognition
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005634	cellular_component	nucleus
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0005685	cellular_component	U1 snRNP
E	0005686	cellular_component	U2 snRNP
E	0005687	cellular_component	U4 snRNP
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0045292	biological_process	mRNA cis splicing, via spliceosome
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0070990	molecular_function	snRNP binding
E	0071004	cellular_component	U2-type prespliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
E	0071014	cellular_component	post-mRNA release spliceosomal complex
E	0120114	cellular_component	Sm-like protein family complex
E	1990904	cellular_component	ribonucleoprotein complex
f	0000243	cellular_component	commitment complex
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000395	biological_process	mRNA 5'-splice site recognition
f	0003723	molecular_function	RNA binding
f	0003729	molecular_function	mRNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006396	biological_process	RNA processing
f	0006397	biological_process	mRNA processing
f	0008380	biological_process	RNA splicing
f	0034715	cellular_component	pICln-Sm protein complex
f	0034719	cellular_component	SMN-Sm protein complex
f	0045292	biological_process	mRNA cis splicing, via spliceosome
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071004	cellular_component	U2-type prespliceosome
f	0071011	cellular_component	precatalytic spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0071014	cellular_component	post-mRNA release spliceosomal complex
f	0097525	cellular_component	spliceosomal snRNP complex
f	0097526	cellular_component	spliceosomal tri-snRNP complex
f	1990904	cellular_component	ribonucleoprotein complex
F	0000243	cellular_component	commitment complex
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000395	biological_process	mRNA 5'-splice site recognition
F	0003723	molecular_function	RNA binding
F	0003729	molecular_function	mRNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005681	cellular_component	spliceosomal complex
F	0005682	cellular_component	U5 snRNP
F	0005685	cellular_component	U1 snRNP
F	0005686	cellular_component	U2 snRNP
F	0005687	cellular_component	U4 snRNP
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006396	biological_process	RNA processing
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0034715	cellular_component	pICln-Sm protein complex
F	0034719	cellular_component	SMN-Sm protein complex
F	0045292	biological_process	mRNA cis splicing, via spliceosome
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071004	cellular_component	U2-type prespliceosome
F	0071011	cellular_component	precatalytic spliceosome
F	0071013	cellular_component	catalytic step 2 spliceosome
F	0071014	cellular_component	post-mRNA release spliceosomal complex
F	0097525	cellular_component	spliceosomal snRNP complex
F	0097526	cellular_component	spliceosomal tri-snRNP complex
F	1990904	cellular_component	ribonucleoprotein complex
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0000974	cellular_component	Prp19 complex
g	0003729	molecular_function	mRNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0045292	biological_process	mRNA cis splicing, via spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0071014	cellular_component	post-mRNA release spliceosomal complex
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000395	biological_process	mRNA 5'-splice site recognition
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0000974	cellular_component	Prp19 complex
G	0003723	molecular_function	RNA binding
G	0005634	cellular_component	nucleus
G	0005681	cellular_component	spliceosomal complex
G	0005682	cellular_component	U5 snRNP
G	0005685	cellular_component	U1 snRNP
G	0005686	cellular_component	U2 snRNP
G	0005829	cellular_component	cytosol
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0030532	cellular_component	small nuclear ribonucleoprotein complex
G	0034715	cellular_component	pICln-Sm protein complex
G	0045292	biological_process	mRNA cis splicing, via spliceosome
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0071004	cellular_component	U2-type prespliceosome
G	0071011	cellular_component	precatalytic spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
G	0071014	cellular_component	post-mRNA release spliceosomal complex
G	1990904	cellular_component	ribonucleoprotein complex
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0000974	cellular_component	Prp19 complex
h	0003723	molecular_function	RNA binding
h	0005634	cellular_component	nucleus
h	0005681	cellular_component	spliceosomal complex
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0045292	biological_process	mRNA cis splicing, via spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0071014	cellular_component	post-mRNA release spliceosomal complex
H	0000387	biological_process	spliceosomal snRNP assembly
H	0000395	biological_process	mRNA 5'-splice site recognition
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003723	molecular_function	RNA binding
H	0005634	cellular_component	nucleus
H	0005681	cellular_component	spliceosomal complex
H	0005682	cellular_component	U5 snRNP
H	0005685	cellular_component	U1 snRNP
H	0005686	cellular_component	U2 snRNP
H	0005687	cellular_component	U4 snRNP
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0034715	cellular_component	pICln-Sm protein complex
H	0045292	biological_process	mRNA cis splicing, via spliceosome
H	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
H	0071004	cellular_component	U2-type prespliceosome
H	0071011	cellular_component	precatalytic spliceosome
H	0071014	cellular_component	post-mRNA release spliceosomal complex
H	0120114	cellular_component	Sm-like protein family complex
H	1990904	cellular_component	ribonucleoprotein complex
i	0000974	cellular_component	Prp19 complex
i	0003674	molecular_function	molecular_function
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005681	cellular_component	spliceosomal complex
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0045292	biological_process	mRNA cis splicing, via spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0071014	cellular_component	post-mRNA release spliceosomal complex
I	0000395	biological_process	mRNA 5'-splice site recognition
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003723	molecular_function	RNA binding
I	0005634	cellular_component	nucleus
I	0005681	cellular_component	spliceosomal complex
I	0005682	cellular_component	U5 snRNP
I	0005685	cellular_component	U1 snRNP
I	0005686	cellular_component	U2 snRNP
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0022618	biological_process	protein-RNA complex assembly
I	0034715	cellular_component	pICln-Sm protein complex
I	0045292	biological_process	mRNA cis splicing, via spliceosome
I	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
I	0071013	cellular_component	catalytic step 2 spliceosome
I	0071014	cellular_component	post-mRNA release spliceosomal complex
I	1990904	cellular_component	ribonucleoprotein complex
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0005634	cellular_component	nucleus
j	0005681	cellular_component	spliceosomal complex
j	0005686	cellular_component	U2 snRNP
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030620	molecular_function	U2 snRNA binding
j	0045292	biological_process	mRNA cis splicing, via spliceosome
j	0071004	cellular_component	U2-type prespliceosome
j	0071014	cellular_component	post-mRNA release spliceosomal complex
J	0000395	biological_process	mRNA 5'-splice site recognition
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003723	molecular_function	RNA binding
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0005682	cellular_component	U5 snRNP
J	0005685	cellular_component	U1 snRNP
J	0005686	cellular_component	U2 snRNP
J	0005687	cellular_component	U4 snRNP
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0034719	cellular_component	SMN-Sm protein complex
J	0045292	biological_process	mRNA cis splicing, via spliceosome
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0071004	cellular_component	U2-type prespliceosome
J	0071011	cellular_component	precatalytic spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
J	0071014	cellular_component	post-mRNA release spliceosomal complex
J	0097526	cellular_component	spliceosomal tri-snRNP complex
J	0120114	cellular_component	Sm-like protein family complex
J	1990904	cellular_component	ribonucleoprotein complex
k	0003676	molecular_function	nucleic acid binding
k	0003723	molecular_function	RNA binding
k	0005634	cellular_component	nucleus
k	0005681	cellular_component	spliceosomal complex
k	0005686	cellular_component	U2 snRNP
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030620	molecular_function	U2 snRNA binding
k	0045292	biological_process	mRNA cis splicing, via spliceosome
k	0071004	cellular_component	U2-type prespliceosome
k	1990904	cellular_component	ribonucleoprotein complex
K	0000398	biological_process	mRNA splicing, via spliceosome
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000395	biological_process	mRNA 5'-splice site recognition
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0000974	cellular_component	Prp19 complex
l	0003723	molecular_function	RNA binding
l	0005634	cellular_component	nucleus
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034715	cellular_component	pICln-Sm protein complex
l	0045292	biological_process	mRNA cis splicing, via spliceosome
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0071004	cellular_component	U2-type prespliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0071014	cellular_component	post-mRNA release spliceosomal complex
l	1990904	cellular_component	ribonucleoprotein complex
L	0000375	biological_process	RNA splicing, via transesterification reactions
L	0003674	molecular_function	molecular_function
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0005682	cellular_component	U5 snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0045292	biological_process	mRNA cis splicing, via spliceosome
L	0071013	cellular_component	catalytic step 2 spliceosome
L	0071014	cellular_component	post-mRNA release spliceosomal complex
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000395	biological_process	mRNA 5'-splice site recognition
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005634	cellular_component	nucleus
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0034715	cellular_component	pICln-Sm protein complex
m	0045292	biological_process	mRNA cis splicing, via spliceosome
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0071004	cellular_component	U2-type prespliceosome
m	0071011	cellular_component	precatalytic spliceosome
m	0071014	cellular_component	post-mRNA release spliceosomal complex
m	0120114	cellular_component	Sm-like protein family complex
m	1990904	cellular_component	ribonucleoprotein complex
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0045292	biological_process	mRNA cis splicing, via spliceosome
M	0060090	molecular_function	molecular adaptor activity
M	0071014	cellular_component	post-mRNA release spliceosomal complex
n	0000395	biological_process	mRNA 5'-splice site recognition
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005634	cellular_component	nucleus
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0022618	biological_process	protein-RNA complex assembly
n	0034715	cellular_component	pICln-Sm protein complex
n	0045292	biological_process	mRNA cis splicing, via spliceosome
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0071014	cellular_component	post-mRNA release spliceosomal complex
n	1990904	cellular_component	ribonucleoprotein complex
o	0000395	biological_process	mRNA 5'-splice site recognition
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003723	molecular_function	RNA binding
o	0005634	cellular_component	nucleus
o	0005681	cellular_component	spliceosomal complex
o	0005682	cellular_component	U5 snRNP
o	0005685	cellular_component	U1 snRNP
o	0005686	cellular_component	U2 snRNP
o	0005687	cellular_component	U4 snRNP
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0006397	biological_process	mRNA processing
o	0008380	biological_process	RNA splicing
o	0034719	cellular_component	SMN-Sm protein complex
o	0045292	biological_process	mRNA cis splicing, via spliceosome
o	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
o	0071004	cellular_component	U2-type prespliceosome
o	0071011	cellular_component	precatalytic spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
o	0071014	cellular_component	post-mRNA release spliceosomal complex
o	0097526	cellular_component	spliceosomal tri-snRNP complex
o	0120114	cellular_component	Sm-like protein family complex
o	1990904	cellular_component	ribonucleoprotein complex
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0006396	biological_process	RNA processing
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0006396	biological_process	RNA processing
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000974	cellular_component	Prp19 complex
S	0004842	molecular_function	ubiquitin-protein transferase activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005635	cellular_component	nuclear envelope
S	0005681	cellular_component	spliceosomal complex
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006281	biological_process	DNA repair
S	0006397	biological_process	mRNA processing
S	0006974	biological_process	DNA damage response
S	0008380	biological_process	RNA splicing
S	0016567	biological_process	protein ubiquitination
S	0016740	molecular_function	transferase activity
S	0045292	biological_process	mRNA cis splicing, via spliceosome
S	0061630	molecular_function	ubiquitin protein ligase activity
S	0070534	biological_process	protein K63-linked ubiquitination
S	0071006	cellular_component	U2-type catalytic step 1 spliceosome
S	0071014	cellular_component	post-mRNA release spliceosomal complex
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000974	cellular_component	Prp19 complex
T	0004842	molecular_function	ubiquitin-protein transferase activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005635	cellular_component	nuclear envelope
T	0005681	cellular_component	spliceosomal complex
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006281	biological_process	DNA repair
T	0006397	biological_process	mRNA processing
T	0006974	biological_process	DNA damage response
T	0008380	biological_process	RNA splicing
T	0016567	biological_process	protein ubiquitination
T	0016740	molecular_function	transferase activity
T	0045292	biological_process	mRNA cis splicing, via spliceosome
T	0061630	molecular_function	ubiquitin protein ligase activity
T	0070534	biological_process	protein K63-linked ubiquitination
T	0071006	cellular_component	U2-type catalytic step 1 spliceosome
T	0071014	cellular_component	post-mRNA release spliceosomal complex
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0000974	cellular_component	Prp19 complex
U	0004842	molecular_function	ubiquitin-protein transferase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005635	cellular_component	nuclear envelope
U	0005681	cellular_component	spliceosomal complex
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006281	biological_process	DNA repair
U	0006397	biological_process	mRNA processing
U	0006974	biological_process	DNA damage response
U	0008380	biological_process	RNA splicing
U	0016567	biological_process	protein ubiquitination
U	0016740	molecular_function	transferase activity
U	0045292	biological_process	mRNA cis splicing, via spliceosome
U	0061630	molecular_function	ubiquitin protein ligase activity
U	0070534	biological_process	protein K63-linked ubiquitination
U	0071006	cellular_component	U2-type catalytic step 1 spliceosome
U	0071014	cellular_component	post-mRNA release spliceosomal complex
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0000974	cellular_component	Prp19 complex
V	0004842	molecular_function	ubiquitin-protein transferase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005635	cellular_component	nuclear envelope
V	0005681	cellular_component	spliceosomal complex
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006397	biological_process	mRNA processing
V	0006974	biological_process	DNA damage response
V	0008380	biological_process	RNA splicing
V	0016567	biological_process	protein ubiquitination
V	0016740	molecular_function	transferase activity
V	0045292	biological_process	mRNA cis splicing, via spliceosome
V	0061630	molecular_function	ubiquitin protein ligase activity
V	0070534	biological_process	protein K63-linked ubiquitination
V	0071006	cellular_component	U2-type catalytic step 1 spliceosome
V	0071014	cellular_component	post-mRNA release spliceosomal complex
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0000974	cellular_component	Prp19 complex
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005681	cellular_component	spliceosomal complex
W	0005829	cellular_component	cytosol
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0045292	biological_process	mRNA cis splicing, via spliceosome
W	0071014	cellular_component	post-mRNA release spliceosomal complex
W	0140602	cellular_component	nucleolar peripheral inclusion body
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0000974	cellular_component	Prp19 complex
X	0003729	molecular_function	mRNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005681	cellular_component	spliceosomal complex
X	0005684	cellular_component	U2-type spliceosomal complex
X	0006397	biological_process	mRNA processing
X	0008380	biological_process	RNA splicing
X	0045292	biological_process	mRNA cis splicing, via spliceosome
X	0071013	cellular_component	catalytic step 2 spliceosome
X	0071014	cellular_component	post-mRNA release spliceosomal complex
Y	0003676	molecular_function	nucleic acid binding
Y	0003723	molecular_function	RNA binding
Y	0046872	molecular_function	metal ion binding
Z	0000243	cellular_component	commitment complex
Z	0000387	biological_process	spliceosomal snRNP assembly
Z	0000395	biological_process	mRNA 5'-splice site recognition
Z	0003723	molecular_function	RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005681	cellular_component	spliceosomal complex
Z	0005682	cellular_component	U5 snRNP
Z	0005685	cellular_component	U1 snRNP
Z	0005686	cellular_component	U2 snRNP
Z	0005687	cellular_component	U4 snRNP
Z	0005829	cellular_component	cytosol
Z	0006396	biological_process	RNA processing
Z	0006397	biological_process	mRNA processing
Z	0008380	biological_process	RNA splicing
Z	0034719	cellular_component	SMN-Sm protein complex
Z	0045292	biological_process	mRNA cis splicing, via spliceosome
Z	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Z	0071004	cellular_component	U2-type prespliceosome
Z	0071011	cellular_component	precatalytic spliceosome
Z	0071013	cellular_component	catalytic step 2 spliceosome
Z	0071014	cellular_component	post-mRNA release spliceosomal complex
Z	0097526	cellular_component	spliceosomal tri-snRNP complex
Z	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YdgViFHRVIpdFViQGG

Chain	Residue	Details
d	TYR38-GLY55

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTAgrDaVARVWDM

Chain	Residue	Details
K	LEU262-MET276
K	VAL304-LEU318
L	LEU151-SER165
L	VAL192-LEU206
g	LEU282-VAL296
S	VAL391-LEU405

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18257517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	263
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	430
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	39
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	31
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	35
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	11
Details	Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18257517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	280
Details	Domain: {"description":"U-box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	49
Details	Domain: {"description":"HTH myb-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	45
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	27
Details	Zinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	153
Details	Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	15
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	32
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	21
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	21
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	21
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	38
Details	Domain: {"description":"LRRCT"}

Chain

Residue

Details

---