3JAB
Domain organization and conformational plasticity of the G protein effector, PDE6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0097381 | cellular_component | photoreceptor disc membrane |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007601 | biological_process | visual perception |
| D | 0030553 | molecular_function | cGMP binding |
| M | 0097381 | cellular_component | photoreceptor disc membrane |
| O | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| O | 0007165 | biological_process | signal transduction |
| O | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| P | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| P | 0007601 | biological_process | visual perception |
| P | 0030553 | molecular_function | cGMP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IBM C 901 |
| Chain | Residue |
| C | LEU765 |
| C | VAL782 |
| C | PHE786 |
| C | GLN817 |
| C | PHE820 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IBM C 902 |
| Chain | Residue |
| C | ILE706 |
| C | TYR709 |
| C | GLN699 |
| C | LEU701 |
| C | SER702 |
| C | LEU704 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IBM O 901 |
| Chain | Residue |
| O | LEU765 |
| O | VAL782 |
| O | PHE786 |
| O | GLN817 |
| O | PHE820 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IBM O 902 |
| Chain | Residue |
| O | GLN699 |
| O | LEU701 |
| O | SER702 |
| O | LEU704 |
| O | ILE706 |
| O | TYR709 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY |
| Chain | Residue | Details |
| C | HIS653-TYR664 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YYCNAGH |
| Chain | Residue | Details |
| H | TYR90-HIS96 | |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q922S4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O76074","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
