Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3IK9

Human GST A1-1-GIMF with GSDHN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004601	molecular_function	peroxidase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0004769	molecular_function	steroid Delta-isomerase activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0030855	biological_process	epithelial cell differentiation
A	0042167	biological_process	heme catabolic process
A	0043651	biological_process	linoleic acid metabolic process
A	0070062	cellular_component	extracellular exosome
A	0098869	biological_process	cellular oxidant detoxification
A	0140104	molecular_function	molecular carrier activity
A	1901687	biological_process	glutathione derivative biosynthetic process
B	0004364	molecular_function	glutathione transferase activity
B	0004601	molecular_function	peroxidase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0004769	molecular_function	steroid Delta-isomerase activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016853	molecular_function	isomerase activity
B	0030855	biological_process	epithelial cell differentiation
B	0042167	biological_process	heme catabolic process
B	0043651	biological_process	linoleic acid metabolic process
B	0070062	cellular_component	extracellular exosome
B	0098869	biological_process	cellular oxidant detoxification
B	0140104	molecular_function	molecular carrier activity
B	1901687	biological_process	glutathione derivative biosynthetic process
C	0004364	molecular_function	glutathione transferase activity
C	0004601	molecular_function	peroxidase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0004769	molecular_function	steroid Delta-isomerase activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016853	molecular_function	isomerase activity
C	0030855	biological_process	epithelial cell differentiation
C	0042167	biological_process	heme catabolic process
C	0043651	biological_process	linoleic acid metabolic process
C	0070062	cellular_component	extracellular exosome
C	0098869	biological_process	cellular oxidant detoxification
C	0140104	molecular_function	molecular carrier activity
C	1901687	biological_process	glutathione derivative biosynthetic process
D	0004364	molecular_function	glutathione transferase activity
D	0004601	molecular_function	peroxidase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0004769	molecular_function	steroid Delta-isomerase activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0016853	molecular_function	isomerase activity
D	0030855	biological_process	epithelial cell differentiation
D	0042167	biological_process	heme catabolic process
D	0043651	biological_process	linoleic acid metabolic process
D	0070062	cellular_component	extracellular exosome
D	0098869	biological_process	cellular oxidant detoxification
D	0140104	molecular_function	molecular carrier activity
D	1901687	biological_process	glutathione derivative biosynthetic process
E	0004364	molecular_function	glutathione transferase activity
E	0004601	molecular_function	peroxidase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0004769	molecular_function	steroid Delta-isomerase activity
E	0005504	molecular_function	fatty acid binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006693	biological_process	prostaglandin metabolic process
E	0006749	biological_process	glutathione metabolic process
E	0006805	biological_process	xenobiotic metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016853	molecular_function	isomerase activity
E	0030855	biological_process	epithelial cell differentiation
E	0042167	biological_process	heme catabolic process
E	0043651	biological_process	linoleic acid metabolic process
E	0070062	cellular_component	extracellular exosome
E	0098869	biological_process	cellular oxidant detoxification
E	0140104	molecular_function	molecular carrier activity
E	1901687	biological_process	glutathione derivative biosynthetic process
F	0004364	molecular_function	glutathione transferase activity
F	0004601	molecular_function	peroxidase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0004769	molecular_function	steroid Delta-isomerase activity
F	0005504	molecular_function	fatty acid binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006693	biological_process	prostaglandin metabolic process
F	0006749	biological_process	glutathione metabolic process
F	0006805	biological_process	xenobiotic metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0016853	molecular_function	isomerase activity
F	0030855	biological_process	epithelial cell differentiation
F	0042167	biological_process	heme catabolic process
F	0043651	biological_process	linoleic acid metabolic process
F	0070062	cellular_component	extracellular exosome
F	0098869	biological_process	cellular oxidant detoxification
F	0140104	molecular_function	molecular carrier activity
F	1901687	biological_process	glutathione derivative biosynthetic process
G	0004364	molecular_function	glutathione transferase activity
G	0004601	molecular_function	peroxidase activity
G	0004602	molecular_function	glutathione peroxidase activity
G	0004769	molecular_function	steroid Delta-isomerase activity
G	0005504	molecular_function	fatty acid binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006629	biological_process	lipid metabolic process
G	0006693	biological_process	prostaglandin metabolic process
G	0006749	biological_process	glutathione metabolic process
G	0006805	biological_process	xenobiotic metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016740	molecular_function	transferase activity
G	0016853	molecular_function	isomerase activity
G	0030855	biological_process	epithelial cell differentiation
G	0042167	biological_process	heme catabolic process
G	0043651	biological_process	linoleic acid metabolic process
G	0070062	cellular_component	extracellular exosome
G	0098869	biological_process	cellular oxidant detoxification
G	0140104	molecular_function	molecular carrier activity
G	1901687	biological_process	glutathione derivative biosynthetic process
H	0004364	molecular_function	glutathione transferase activity
H	0004601	molecular_function	peroxidase activity
H	0004602	molecular_function	glutathione peroxidase activity
H	0004769	molecular_function	steroid Delta-isomerase activity
H	0005504	molecular_function	fatty acid binding
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006629	biological_process	lipid metabolic process
H	0006693	biological_process	prostaglandin metabolic process
H	0006749	biological_process	glutathione metabolic process
H	0006805	biological_process	xenobiotic metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016740	molecular_function	transferase activity
H	0016853	molecular_function	isomerase activity
H	0030855	biological_process	epithelial cell differentiation
H	0042167	biological_process	heme catabolic process
H	0043651	biological_process	linoleic acid metabolic process
H	0070062	cellular_component	extracellular exosome
H	0098869	biological_process	cellular oxidant detoxification
H	0140104	molecular_function	molecular carrier activity
H	1901687	biological_process	glutathione derivative biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BOB A 501

Chain	Residue
A	TYR9
A	TYR212
A	HOH6039
B	ASP101
B	ARG131
A	GLY14
A	ARG15
A	ARG45
A	GLN54
A	VAL55
A	GLN67
A	THR68
A	MET108

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BOB B 502

Chain	Residue
A	ASP101
A	ARG131
B	TYR9
B	GLY14
B	ARG15
B	GLN54
B	VAL55
B	GLN67
B	THR68
B	MET108
B	TYR212
B	PHE220

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BOB C 503

Chain	Residue
C	TYR9
C	GLY14
C	ARG15
C	ARG45
C	GLN54
C	VAL55
C	GLN67
C	THR68
C	TYR212
C	PHE220
D	ASP101
D	ARG131

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BOB D 504

Chain	Residue
C	ASP101
C	ARG131
D	TYR9
D	GLY14
D	ARG15
D	ARG45
D	GLN54
D	VAL55
D	GLN67
D	THR68
D	ILE107
D	PHE111
D	TYR212
D	TYR217
D	PHE220

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BOB E 505

Chain	Residue
E	TYR9
E	ARG15
E	ARG45
E	GLN54
E	VAL55
E	PRO56
E	GLN67
E	THR68
E	PHE111
E	TYR212
E	PHE220
F	ASP101
F	ARG131

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BOB F 506

Chain	Residue
E	ASP101
E	ARG131
F	TYR9
F	GLY14
F	ARG15
F	GLN54
F	VAL55
F	GLN67
F	THR68
F	PHE111
F	TYR212

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BOB G 507

Chain	Residue
G	TYR9
G	GLY14
G	ARG15
G	ARG45
G	GLN54
G	VAL55
G	GLN67
G	THR68
G	PHE111
G	TYR212
G	PHE220
H	ASP101
H	ARG131

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BOB H 508

Chain	Residue
H	THR68
H	PHE111
H	TYR212
H	PHE220
G	ASP101
G	ARG131
H	TYR9
H	GLY14
H	ARG15
H	ARG45
H	GLN54
H	VAL55
H	PRO56
H	GLN67

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	976
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16421451","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19618965","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)