Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3IGQ

Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 701

Chain	Residue
A	PRO74
A	GLU75
A	ILE76
A	ARG77
A	ARG85
A	HOH237

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 801

Chain	Residue
A	PRO68
A	ILE71
A	HOH226

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG A 700

Chain	Residue
A	CYS27
A	HOH314

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 901

Chain	Residue
A	PHE78
A	ARG85

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY B 701

Chain	Residue
B	PRO74
B	GLU75
B	ILE76
B	ARG77
B	ARG85
B	TYR102

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 801

Chain	Residue
B	PRO68
B	ILE71
B	HOH430

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG B 700

Chain	Residue
B	CYS27
B	HOH313

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 901

Chain	Residue
B	PHE78
B	ALA84
B	ARG85

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY C 701

Chain	Residue
C	PRO74
C	GLU75
C	ILE76
C	ARG77
C	ARG85
C	TYR102
C	HOH327

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA C 801

Chain	Residue
C	PRO68
C	ILE71
C	HOH234

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG C 700

Chain	Residue
C	CYS27
C	HOH232

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 901

Chain	Residue
C	PHE78
C	ALA84
C	ARG85

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY D 701

Chain	Residue
D	PRO74
D	GLU75
D	ILE76
D	ARG85
D	HOH225

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 801

Chain	Residue
D	PRO68
D	ILE71
D	HOH205

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG D 700

Chain	Residue
D	LEU24
D	CYS27
D	HOH311

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 901

Chain	Residue
D	PHE78
D	ALA84
D	ARG85

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY E 701

Chain	Residue
E	PRO74
E	ILE76
E	ARG77
E	ARG85
E	HOH213

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA E 801

Chain	Residue
E	PRO68
E	ILE71
E	HOH403

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG E 700

Chain	Residue
E	CYS27
E	HOH312

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 901

Chain	Residue
E	PHE78
E	ARG85

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY F 701

Chain	Residue
F	PRO74
F	GLU75
F	ILE76
F	ARG85
F	HOH208
F	HOH234
F	HOH350

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA F 801

Chain	Residue
F	PRO68
F	ILE71
F	HOH237
F	HOH245

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE HG F 700

Chain	Residue
F	LEU24
F	CYS27

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 901

Chain	Residue
F	PHE78
F	ARG85

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1146
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
B	GLN2-GLN193
C	GLN2-GLN193
D	GLN2-GLN193
E	GLN2-GLN193
F	GLN2-GLN193

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)