3IG8

Saccharomyces cerevisiae glutamate cysteine ligase in complex with Mg2+, L-glutamate and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004357	molecular_function	glutamate-cysteine ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006750	biological_process	glutathione biosynthetic process
A	0016874	molecular_function	ligase activity
A	0042542	biological_process	response to hydrogen peroxide
A	0046686	biological_process	response to cadmium ion

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU A 693

Chain	Residue
A	GLU52
A	MG695
A	HOH806
A	HOH807
A	GLU96
A	CYS264
A	CYS266
A	GLN268
A	ARG313
A	ILE317
A	TYR362
A	ARG472

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP A 694

Chain	Residue
A	PHE46
A	GLY48
A	ASP49
A	GLU50
A	GLU103
A	THR270
A	GLN272
A	ARG468
A	GLU470
A	MG696
A	MG697
A	HOH766
A	HOH798
A	HOH803
A	HOH805

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 695

Chain	Residue
A	GLU52
A	GLU96
A	GLU103
A	GLN268
A	GLU693
A	MG697

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 696

Chain	Residue
A	GLU50
A	GLN268
A	GLU470
A	ADP694

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 697

Chain	Residue
A	GLU50
A	GLU103
A	ADP694
A	MG695
A	HOH808

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site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE A 698

Chain	Residue
A	GLY163
A	CYS164
A	PRO165
A	ASP166
A	PRO173
A	TRP174
A	PHE185
A	TYR232

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