3I54
Crystal structure of MtbCRP in complex with cAMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0030552 | molecular_function | cAMP binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0030552 | molecular_function | cAMP binding |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0030552 | molecular_function | cAMP binding |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CMP A 301 |
| Chain | Residue |
| A | PHE38 |
| A | ARG89 |
| A | THR90 |
| A | SER91 |
| A | ARG130 |
| A | THR134 |
| B | ASN135 |
| A | ILE57 |
| A | LEU69 |
| A | MET72 |
| A | PHE78 |
| A | GLY79 |
| A | GLU80 |
| A | LEU81 |
| A | SER82 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CMP B 301 |
| Chain | Residue |
| A | ASN135 |
| B | PHE38 |
| B | ILE57 |
| B | LEU69 |
| B | THR70 |
| B | MET72 |
| B | PHE78 |
| B | GLY79 |
| B | GLU80 |
| B | LEU81 |
| B | SER82 |
| B | ARG89 |
| B | THR90 |
| B | SER91 |
| B | ARG130 |
| B | THR134 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CMP C 301 |
| Chain | Residue |
| C | PHE38 |
| C | ILE57 |
| C | LEU69 |
| C | MET72 |
| C | PHE78 |
| C | GLY79 |
| C | GLU80 |
| C | LEU81 |
| C | SER82 |
| C | ARG89 |
| C | THR90 |
| C | SER91 |
| C | ARG130 |
| C | THR134 |
| D | ASN135 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CMP D 301 |
| Chain | Residue |
| C | ASN135 |
| D | PHE38 |
| D | ILE57 |
| D | LEU69 |
| D | THR70 |
| D | MET72 |
| D | PHE78 |
| D | GLY79 |
| D | GLU80 |
| D | LEU81 |
| D | SER82 |
| D | ARG89 |
| D | THR90 |
| D | SER91 |
| D | ARG130 |
| D | THR134 |
| D | HOH242 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 292 |
| Details | Domain: {"description":"HTH crp-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00387","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 76 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00387","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 62 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0ACJ8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of cAMP receptor protein from Mycobacterium tuberculosis in complex with DNA and cAMP.","authors":["Akhter Y.","Pogenberg V.","Hasnain S.E.","Wilmanns M."]}}]} |
| Chain | Residue | Details |
