3I54

Crystal structure of MtbCRP in complex with cAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0030552	molecular_function	cAMP binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006355	biological_process	regulation of DNA-templated transcription
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0030552	molecular_function	cAMP binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006355	biological_process	regulation of DNA-templated transcription
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0030552	molecular_function	cAMP binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006355	biological_process	regulation of DNA-templated transcription
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0030552	molecular_function	cAMP binding
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CMP A 301

Chain	Residue
A	PHE38
A	ARG89
A	THR90
A	SER91
A	ARG130
A	THR134
B	ASN135
A	ILE57
A	LEU69
A	MET72
A	PHE78
A	GLY79
A	GLU80
A	LEU81
A	SER82

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CMP B 301

Chain	Residue
A	ASN135
B	PHE38
B	ILE57
B	LEU69
B	THR70
B	MET72
B	PHE78
B	GLY79
B	GLU80
B	LEU81
B	SER82
B	ARG89
B	THR90
B	SER91
B	ARG130
B	THR134

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CMP C 301

Chain	Residue
C	PHE38
C	ILE57
C	LEU69
C	MET72
C	PHE78
C	GLY79
C	GLU80
C	LEU81
C	SER82
C	ARG89
C	THR90
C	SER91
C	ARG130
C	THR134
D	ASN135

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CMP D 301

Chain	Residue
C	ASN135
D	PHE38
D	ILE57
D	LEU69
D	THR70
D	MET72
D	PHE78
D	GLY79
D	GLU80
D	LEU81
D	SER82
D	ARG89
D	THR90
D	SER91
D	ARG130
D	THR134
D	HOH242

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387

Chain	Residue	Details
A	GLN177-ALA196
B	GLN177-ALA196
C	GLN177-ALA196
D	GLN177-ALA196

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0ACJ8

Chain	Residue	Details
A	GLY64
D	GLY64
D	ILE142
D	GLU178
A	ILE142
A	GLU178
B	GLY64
B	ILE142
B	GLU178
C	GLY64
C	ILE142
C	GLU178

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|Ref.9

Chain	Residue	Details
A	GLY79
D	GLY79
D	ARG89
D	THR134
A	ARG89
A	THR134
B	GLY79
B	ARG89
B	THR134
C	GLY79
C	ARG89
C	THR134

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