3HY6

Structure of human MTHFS with ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005542	molecular_function	folic acid binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006536	biological_process	glutamate metabolic process
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0015942	biological_process	formate metabolic process
A	0016874	molecular_function	ligase activity
A	0030272	molecular_function	5-formyltetrahydrofolate cyclo-ligase activity
A	0035999	biological_process	tetrahydrofolate interconversion
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046655	biological_process	folic acid metabolic process
A	0046657	biological_process	folic acid catabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 204

Chain	Residue
A	HIS89
A	ASP91
A	HIS163
A	HOH225
A	HOH237
A	HOH294

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 205

Chain	Residue
A	PHE85
A	GLN86

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 206

Chain	Residue
A	HOH276
A	HOH277
A	HOH324
A	HOH334
A	HIS142

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 207

Chain	Residue
A	ARG29
A	GLN59
A	GLU61

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 208

Chain	Residue
A	HIS89
A	MET90
A	ARG159
A	HOH264
A	HOH322

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 209

Chain	Residue
A	LEU104
A	LEU104
A	LYS106
A	HOH318

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 210

Chain	Residue
A	CYS180
A	LEU181
A	HOH255
A	HOH313

---

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 211

Chain	Residue
A	ARG145
A	GLY147
A	ARG148
A	LYS150
A	GLY151
A	TYR152
A	TYR153
A	HOH254
A	ADP302
A	HOH306

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 212

Chain	Residue
A	MET92
A	ALA123
A	LEU124
A	TYR156
A	ARG159

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 213

Chain	Residue
A	ARG145
A	ASP154
A	ASP189
A	ADP302
A	HOH307

---

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP A 302

Chain	Residue
A	LYS10
A	ARG14
A	GLY147
A	ARG148
A	GLY149
A	LYS150
A	GLY151
A	ASP154
A	ASP189
A	PO4211
A	MG213
A	HOH306
A	HOH307
A	HOH321
A	HOH330
A	HOH343

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 214

Chain	Residue
A	ASN144
A	VAL185
A	ASP189
A	LYS191
A	HOH298

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 215

Chain	Residue
A	GLU45

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 216

Chain	Residue
A	ALA2
A	GLU96
A	GLU100
A	ARG120

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 217

Chain	Residue
A	TYR197
A	GLU198
A	HOH268

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NI A 218

Chain	Residue
A	GLU96

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 219

Chain	Residue
A	ASP193

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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