3HTX

Crystal structure of small RNA methyltransferase HEN1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0003723	molecular_function	RNA binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008168	molecular_function	methyltransferase activity
A	0008171	molecular_function	O-methyltransferase activity
A	0008173	molecular_function	RNA methyltransferase activity
A	0009616	biological_process	RNAi-mediated antiviral immune response
A	0009909	biological_process	regulation of flower development
A	0010093	biological_process	specification of floral organ identity
A	0010267	biological_process	ta-siRNA processing
A	0010305	biological_process	leaf vascular tissue pattern formation
A	0010589	biological_process	leaf proximal/distal pattern formation
A	0016070	biological_process	RNA metabolic process
A	0016740	molecular_function	transferase activity
A	0030422	biological_process	siRNA processing
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0032259	biological_process	methylation
A	0034587	biological_process	piRNA processing
A	0035196	biological_process	miRNA processing
A	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
A	0046872	molecular_function	metal ion binding
A	0090486	molecular_function	small RNA 2'-O-methyltransferase activity
D	0001510	biological_process	RNA methylation
D	0003723	molecular_function	RNA binding
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0008168	molecular_function	methyltransferase activity
D	0008171	molecular_function	O-methyltransferase activity
D	0008173	molecular_function	RNA methyltransferase activity
D	0009616	biological_process	RNAi-mediated antiviral immune response
D	0009909	biological_process	regulation of flower development
D	0010093	biological_process	specification of floral organ identity
D	0010267	biological_process	ta-siRNA processing
D	0010305	biological_process	leaf vascular tissue pattern formation
D	0010589	biological_process	leaf proximal/distal pattern formation
D	0016070	biological_process	RNA metabolic process
D	0016740	molecular_function	transferase activity
D	0030422	biological_process	siRNA processing
D	0031047	biological_process	regulatory ncRNA-mediated gene silencing
D	0032259	biological_process	methylation
D	0034587	biological_process	piRNA processing
D	0035196	biological_process	miRNA processing
D	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
D	0046872	molecular_function	metal ion binding
D	0090486	molecular_function	small RNA 2'-O-methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 950

Chain	Residue
A	GLU796
A	GLU799
A	HIS800
A	HIS860
B	G22

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH A 951

Chain	Residue
A	ASP745
A	ILE746
A	SER747
A	GLY777
A	SER778
A	ILE779
A	LEU780
A	LEU795
A	GLU796
A	VAL797
A	HIS800
B	G22
A	ARG701
A	GLY721
A	GLY723
A	SER726

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 950

Chain	Residue
D	GLU796
D	GLU799
D	HIS800
D	HIS860
E	G22

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH D 951

Chain	Residue
D	GLY721
D	CYS722
D	SER724
D	SER726
D	ASP745
D	ILE746
D	SER747
D	GLY777
D	SER778
D	ILE779
D	LEU795
D	GLU796
D	VAL797
D	HOH949
E	G22

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Domain: {"description":"DRBM"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	222
Details	Domain: {"description":"HTH La-type RNA-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00332","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19812675","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HTX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---