Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3HHQ

Crystal structure of apo dUT1p from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006226	biological_process	dUMP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035863	biological_process	dITP catabolic process
A	0035870	molecular_function	dITP diphosphatase activity
A	0046081	biological_process	dUTP catabolic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004170	molecular_function	dUTP diphosphatase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006226	biological_process	dUMP biosynthetic process
B	0009117	biological_process	nucleotide metabolic process
B	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035863	biological_process	dITP catabolic process
B	0035870	molecular_function	dITP diphosphatase activity
B	0046081	biological_process	dUTP catabolic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004170	molecular_function	dUTP diphosphatase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006226	biological_process	dUMP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
C	0016787	molecular_function	hydrolase activity
C	0035863	biological_process	dITP catabolic process
C	0035870	molecular_function	dITP diphosphatase activity
C	0046081	biological_process	dUTP catabolic process
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004170	molecular_function	dUTP diphosphatase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006226	biological_process	dUMP biosynthetic process
D	0009117	biological_process	nucleotide metabolic process
D	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
D	0016787	molecular_function	hydrolase activity
D	0035863	biological_process	dITP catabolic process
D	0035870	molecular_function	dITP diphosphatase activity
D	0046081	biological_process	dUTP catabolic process
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0004170	molecular_function	dUTP diphosphatase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006226	biological_process	dUMP biosynthetic process
E	0009117	biological_process	nucleotide metabolic process
E	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
E	0016787	molecular_function	hydrolase activity
E	0035863	biological_process	dITP catabolic process
E	0035870	molecular_function	dITP diphosphatase activity
E	0046081	biological_process	dUTP catabolic process
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0004170	molecular_function	dUTP diphosphatase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006226	biological_process	dUMP biosynthetic process
F	0009117	biological_process	nucleotide metabolic process
F	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
F	0016787	molecular_function	hydrolase activity
F	0035863	biological_process	dITP catabolic process
F	0035870	molecular_function	dITP diphosphatase activity
F	0046081	biological_process	dUTP catabolic process
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0004170	molecular_function	dUTP diphosphatase activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006226	biological_process	dUMP biosynthetic process
G	0009117	biological_process	nucleotide metabolic process
G	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
G	0016787	molecular_function	hydrolase activity
G	0035863	biological_process	dITP catabolic process
G	0035870	molecular_function	dITP diphosphatase activity
G	0046081	biological_process	dUTP catabolic process
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0004170	molecular_function	dUTP diphosphatase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006226	biological_process	dUMP biosynthetic process
H	0009117	biological_process	nucleotide metabolic process
H	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
H	0016787	molecular_function	hydrolase activity
H	0035863	biological_process	dITP catabolic process
H	0035870	molecular_function	dITP diphosphatase activity
H	0046081	biological_process	dUTP catabolic process
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0004170	molecular_function	dUTP diphosphatase activity
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0006226	biological_process	dUMP biosynthetic process
I	0009117	biological_process	nucleotide metabolic process
I	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
I	0016787	molecular_function	hydrolase activity
I	0035863	biological_process	dITP catabolic process
I	0035870	molecular_function	dITP diphosphatase activity
I	0046081	biological_process	dUTP catabolic process
I	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0004170	molecular_function	dUTP diphosphatase activity
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006226	biological_process	dUMP biosynthetic process
J	0009117	biological_process	nucleotide metabolic process
J	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
J	0016787	molecular_function	hydrolase activity
J	0035863	biological_process	dITP catabolic process
J	0035870	molecular_function	dITP diphosphatase activity
J	0046081	biological_process	dUTP catabolic process
J	0046872	molecular_function	metal ion binding
K	0000287	molecular_function	magnesium ion binding
K	0004170	molecular_function	dUTP diphosphatase activity
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006226	biological_process	dUMP biosynthetic process
K	0009117	biological_process	nucleotide metabolic process
K	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
K	0016787	molecular_function	hydrolase activity
K	0035863	biological_process	dITP catabolic process
K	0035870	molecular_function	dITP diphosphatase activity
K	0046081	biological_process	dUTP catabolic process
K	0046872	molecular_function	metal ion binding
L	0000287	molecular_function	magnesium ion binding
L	0004170	molecular_function	dUTP diphosphatase activity
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0006226	biological_process	dUMP biosynthetic process
L	0009117	biological_process	nucleotide metabolic process
L	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
L	0016787	molecular_function	hydrolase activity
L	0035863	biological_process	dITP catabolic process
L	0035870	molecular_function	dITP diphosphatase activity
L	0046081	biological_process	dUTP catabolic process
L	0046872	molecular_function	metal ion binding
M	0000287	molecular_function	magnesium ion binding
M	0004170	molecular_function	dUTP diphosphatase activity
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006226	biological_process	dUMP biosynthetic process
M	0009117	biological_process	nucleotide metabolic process
M	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
M	0016787	molecular_function	hydrolase activity
M	0035863	biological_process	dITP catabolic process
M	0035870	molecular_function	dITP diphosphatase activity
M	0046081	biological_process	dUTP catabolic process
M	0046872	molecular_function	metal ion binding
N	0000287	molecular_function	magnesium ion binding
N	0004170	molecular_function	dUTP diphosphatase activity
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0006226	biological_process	dUMP biosynthetic process
N	0009117	biological_process	nucleotide metabolic process
N	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
N	0016787	molecular_function	hydrolase activity
N	0035863	biological_process	dITP catabolic process
N	0035870	molecular_function	dITP diphosphatase activity
N	0046081	biological_process	dUTP catabolic process
N	0046872	molecular_function	metal ion binding
O	0000287	molecular_function	magnesium ion binding
O	0004170	molecular_function	dUTP diphosphatase activity
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0006226	biological_process	dUMP biosynthetic process
O	0009117	biological_process	nucleotide metabolic process
O	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
O	0016787	molecular_function	hydrolase activity
O	0035863	biological_process	dITP catabolic process
O	0035870	molecular_function	dITP diphosphatase activity
O	0046081	biological_process	dUTP catabolic process
O	0046872	molecular_function	metal ion binding
P	0000287	molecular_function	magnesium ion binding
P	0004170	molecular_function	dUTP diphosphatase activity
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0006226	biological_process	dUMP biosynthetic process
P	0009117	biological_process	nucleotide metabolic process
P	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
P	0016787	molecular_function	hydrolase activity
P	0035863	biological_process	dITP catabolic process
P	0035870	molecular_function	dITP diphosphatase activity
P	0046081	biological_process	dUTP catabolic process
P	0046872	molecular_function	metal ion binding
Q	0000287	molecular_function	magnesium ion binding
Q	0004170	molecular_function	dUTP diphosphatase activity
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0006226	biological_process	dUMP biosynthetic process
Q	0009117	biological_process	nucleotide metabolic process
Q	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
Q	0016787	molecular_function	hydrolase activity
Q	0035863	biological_process	dITP catabolic process
Q	0035870	molecular_function	dITP diphosphatase activity
Q	0046081	biological_process	dUTP catabolic process
Q	0046872	molecular_function	metal ion binding
R	0000287	molecular_function	magnesium ion binding
R	0004170	molecular_function	dUTP diphosphatase activity
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0006226	biological_process	dUMP biosynthetic process
R	0009117	biological_process	nucleotide metabolic process
R	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
R	0016787	molecular_function	hydrolase activity
R	0035863	biological_process	dITP catabolic process
R	0035870	molecular_function	dITP diphosphatase activity
R	0046081	biological_process	dUTP catabolic process
R	0046872	molecular_function	metal ion binding
S	0000287	molecular_function	magnesium ion binding
S	0004170	molecular_function	dUTP diphosphatase activity
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0006226	biological_process	dUMP biosynthetic process
S	0009117	biological_process	nucleotide metabolic process
S	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
S	0016787	molecular_function	hydrolase activity
S	0035863	biological_process	dITP catabolic process
S	0035870	molecular_function	dITP diphosphatase activity
S	0046081	biological_process	dUTP catabolic process
S	0046872	molecular_function	metal ion binding
T	0000287	molecular_function	magnesium ion binding
T	0004170	molecular_function	dUTP diphosphatase activity
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0006226	biological_process	dUMP biosynthetic process
T	0009117	biological_process	nucleotide metabolic process
T	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
T	0016787	molecular_function	hydrolase activity
T	0035863	biological_process	dITP catabolic process
T	0035870	molecular_function	dITP diphosphatase activity
T	0046081	biological_process	dUTP catabolic process
T	0046872	molecular_function	metal ion binding
U	0000287	molecular_function	magnesium ion binding
U	0004170	molecular_function	dUTP diphosphatase activity
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0006226	biological_process	dUMP biosynthetic process
U	0009117	biological_process	nucleotide metabolic process
U	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
U	0016787	molecular_function	hydrolase activity
U	0035863	biological_process	dITP catabolic process
U	0035870	molecular_function	dITP diphosphatase activity
U	0046081	biological_process	dUTP catabolic process
U	0046872	molecular_function	metal ion binding
V	0000287	molecular_function	magnesium ion binding
V	0004170	molecular_function	dUTP diphosphatase activity
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0006226	biological_process	dUMP biosynthetic process
V	0009117	biological_process	nucleotide metabolic process
V	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
V	0016787	molecular_function	hydrolase activity
V	0035863	biological_process	dITP catabolic process
V	0035870	molecular_function	dITP diphosphatase activity
V	0046081	biological_process	dUTP catabolic process
V	0046872	molecular_function	metal ion binding
W	0000287	molecular_function	magnesium ion binding
W	0004170	molecular_function	dUTP diphosphatase activity
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0006226	biological_process	dUMP biosynthetic process
W	0009117	biological_process	nucleotide metabolic process
W	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
W	0016787	molecular_function	hydrolase activity
W	0035863	biological_process	dITP catabolic process
W	0035870	molecular_function	dITP diphosphatase activity
W	0046081	biological_process	dUTP catabolic process
W	0046872	molecular_function	metal ion binding
X	0000287	molecular_function	magnesium ion binding
X	0004170	molecular_function	dUTP diphosphatase activity
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0006226	biological_process	dUMP biosynthetic process
X	0009117	biological_process	nucleotide metabolic process
X	0009213	biological_process	pyrimidine deoxyribonucleoside triphosphate catabolic process
X	0016787	molecular_function	hydrolase activity
X	0035863	biological_process	dITP catabolic process
X	0035870	molecular_function	dITP diphosphatase activity
X	0046081	biological_process	dUTP catabolic process
X	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 148

Chain	Residue
A	ARG68
A	SER69
A	GLY70
A	HOH1209

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 149

Chain	Residue
A	LYS119
C	LYS119

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 150

Chain	Residue
A	HOH156
A	PRO67
A	ARG68
A	VAL112

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 148

Chain	Residue
A	GLN78
A	PHE97
A	HIS99
B	GLN78
B	PHE97
B	HIS99
C	GLN78
C	PHE97
C	HIS99

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 149

Chain	Residue
B	ARG68
B	SER69
B	GLY70
B	HOH432

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 150

Chain	Residue
B	GLN101

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 148

Chain	Residue
C	GLN101

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 149

Chain	Residue
C	ILE120
C	ASP122

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 148

Chain	Residue
D	ARG68
D	SER69
D	GLY70
D	HOH889
D	HOH2011

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 149

Chain	Residue
D	GLN101

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 150

Chain	Residue
D	VAL73
D	LYS74

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 151

Chain	Residue
D	ALA18
D	THR19
D	TYR34
D	THR51

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 152

Chain	Residue
D	ARG64
D	ILE65
D	ALA81
D	GLY82
D	VAL83
F	ARG64

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 148

Chain	Residue
E	SER100
E	GLN101
E	ARG102

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 149

Chain	Residue
E	LYS7
F	ASP123

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 150

Chain	Residue
D	THR89
E	GLU133
K	ALA16

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 F 148

Chain	Residue
D	GLN78
D	PHE97
D	HIS99
E	GLN78
E	PHE97
E	HIS99
F	GLN78
F	PHE97
F	HIS99

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 149

Chain	Residue
D	LYS119
E	LYS119
F	LYS119

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 150

Chain	Residue
F	ARG68
F	SER69
F	GLY70

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL F 151

Chain	Residue
F	GLN37
F	ILE39
F	VAL49
F	SER50
F	HOH2175

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F 152

Chain	Residue
E	THR27
E	ALA29
F	THR61
F	TYR62
F	ASP85
F	ARG86

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO F 153

Chain	Residue
E	SER69
F	VAL83
F	ASP85
F	TYR88
F	HOH2282

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 G 148

Chain	Residue
G	SER100
G	GLN101
G	ARG102
K	ASN75
K	ARG102
K	EDO152

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 149

Chain	Residue
G	LYS119
H	LYS119
I	LYS119

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 150

Chain	Residue
G	ARG68
G	GLY70
G	HOH152

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO G 151

Chain	Residue
G	ALA72
G	ILE77
G	VAL112
G	ALA113
G	PRO67
G	ARG68
G	LEU71

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 148

Chain	Residue
H	SER100
H	GLN101
H	ARG102
X	ALA16

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PEG H 149

Chain	Residue
H	GLN37
H	ASP38
H	ILE39
H	MET48
H	VAL49
H	SER50
H	HOH1409
K	THR19
K	TYR34
K	GLY109

site_id	DC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 I 148

Chain	Residue
G	GLN78
G	PHE97
G	HIS99
H	GLN78
H	PHE97
H	HIS99
I	GLN78
I	PHE97
I	HIS99

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL I 149

Chain	Residue
I	GLN101

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 J 148

Chain	Residue
J	ARG68
J	SER69
J	GLY70
J	ARG111
J	HOH1358
J	HOH1548

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO J 150

Chain	Residue
J	ARG64
J	ILE65
J	ALA81
J	GLY82
J	VAL83
J	HOH158
L	ARG64

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO J 151

Chain	Residue
D	THR40
J	LYS74
J	ASN75
J	ARG102

site_id	DC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG J 152

Chain	Residue
J	ALA81
J	GLY82
J	TYR88
J	GLU91
J	LYS93
J	VAL95
L	SER69

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG J 153

Chain	Residue
J	LYS7
J	VAL8
J	THR56
J	VAL57
J	PRO58
J	VAL59
J	ARG86

site_id	DC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 K 148

Chain	Residue
J	GLN78
J	PHE97
J	HIS99
K	GLN78
K	PHE97
K	HIS99
L	GLN78
L	PHE97
L	HIS99

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 K 149

Chain	Residue
K	ARG68
K	SER69
K	GLY70
K	HOH159

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO K 150

Chain	Residue
K	PRO67
K	ARG68
K	LEU71
K	ALA72
K	ILE77
K	VAL112
K	ALA113

site_id	EC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO K 151

Chain	Residue
J	ARG64
K	ARG64
K	ILE65
K	THR79
K	ALA81
K	GLY82
K	VAL83
K	HOH157

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO K 152

Chain	Residue
G	GLN101
G	SO4148
K	ARG102
K	ASP103

site_id	EC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG K 153

Chain	Residue
D	GLN37
J	SER69
K	ILE65
K	ALA81
K	GLY82
K	LYS93
K	HOH1202
K	HOH2102

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL L 148

Chain	Residue
L	GLY70

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA L 149

Chain	Residue
L	THR79
L	HOH205
L	HOH208
L	HOH209

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL L 150

Chain	Residue
L	GLN101
L	ARG102

site_id	EC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 M 148

Chain	Residue
M	GLN78
M	HIS99
N	GLN78
N	PHE97
N	HIS99
O	GLN78
O	HIS99

site_id	FC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 M 149

Chain	Residue
M	SER100
M	GLN101
M	ARG102
Q	ASN75
Q	ARG102

site_id	FC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA M 150

Chain	Residue
M	ARG64
M	GLU118
N	ARG64
N	GLU118
O	ARG64
O	GLU118

site_id	FC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO M 151

Chain	Residue
M	PRO67
M	ARG68
M	LEU71
M	ALA72
M	ILE77
M	VAL112
M	ALA113

site_id	FC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO M 152

Chain	Residue
M	ARG64
M	PRO67
M	GLN78
M	HOH164
N	THR79
N	GLY80
N	ALA81
N	EDO153
N	HOH157

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO M 153

Chain	Residue
M	VAL83
M	ASP85
O	SER69

site_id	FC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO M 154

Chain	Residue
M	GLN101
M	ASP103

site_id	FC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PEG M 155

Chain	Residue
M	MET44
M	GLY45
M	ASN98
M	HIS99
M	HOH165
N	MET44
N	GLY45
N	ASN98
N	HIS99
O	HIS99

site_id	FC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 N 148

Chain	Residue
M	LYS119
N	LYS119

site_id	FC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 N 149

Chain	Residue
N	SER100
N	GLN101
N	ARG102

site_id	GC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA N 150

Chain	Residue
N	ASN75
N	ASN98
N	SER100
N	ARG102

site_id	GC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL N 151

Chain	Residue
N	THR19
N	TYR34

site_id	GC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL N 152

Chain	Residue
N	GLY70
N	HOH158

site_id	GC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO N 153

Chain	Residue
M	EDO152
N	ARG64
N	PRO67
N	THR79
N	HOH157
N	HOH590
N	HOH1781
O	EDO153

site_id	GC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 O 148

Chain	Residue
O	SER100
O	GLN101
O	ARG102
X	SER100
X	GLN101
X	ARG102

site_id	GC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA O 149

Chain	Residue
M	VAL121
O	ALA29
O	LEU117

site_id	GC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO O 150

Chain	Residue
N	SER69
O	VAL83
O	ASP85

site_id	GC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA O 151

Chain	Residue
O	ALA16
O	ALA18

site_id	GC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO O 152

Chain	Residue
O	ARG68
O	GLY70
O	LEU71
O	HOH2309

site_id	HC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO O 153

Chain	Residue
N	ARG64
N	PRO67
N	EDO153
O	ARG64
O	ILE65
O	ALA81
O	GLY82
O	VAL83

site_id	HC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 P 148

Chain	Residue
P	ARG68
P	GLY70
P	LEU71
P	HOH157

site_id	HC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 P 149

Chain	Residue
P	LYS119
Q	LYS119
R	LYS119

site_id	HC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA P 150

Chain	Residue
P	ALA29
P	LEU117
Q	VAL121

site_id	HC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO P 151

Chain	Residue
P	PRO67
P	ARG68
P	LEU71
P	ALA72
P	ILE77
P	THR79
P	VAL112
P	ALA113

site_id	HC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 Q 148

Chain	Residue
P	GLN78
P	PHE97
P	HIS99
Q	GLN78
Q	PHE97
Q	HIS99
R	GLN78
R	PHE97
R	HIS99

site_id	HC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL Q 149

Chain	Residue
N	ARG14

site_id	HC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO Q 150

Chain	Residue
P	ARG64
P	HOH1195
Q	ARG64
Q	ILE65
Q	ALA81
Q	GLY82
Q	VAL83
Q	HOH157

site_id	HC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO Q 151

Chain	Residue
Q	ALA18
Q	THR19
Q	ILE33
Q	TYR34
Q	THR51

site_id	IC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO Q 152

Chain	Residue
Q	ARG68
Q	GLY70
Q	LEU71

site_id	IC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO Q 153

Chain	Residue
M	LYS74
Q	GLY70
Q	VAL73
Q	LYS74

site_id	IC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 R 148

Chain	Residue
R	SER100
R	GLN101
R	ARG102
R	HOH1303

site_id	IC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO R 150

Chain	Residue
R	TYR88
R	GLU91
R	VAL92
R	LYS93

site_id	IC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO R 151

Chain	Residue
Q	SER69
R	VAL83
R	ASP85
R	TYR88

site_id	IC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 S 148

Chain	Residue
S	GLN78
S	PHE97
S	HIS99
T	GLN78
T	PHE97
T	HIS99
U	GLN78
U	PHE97
U	HIS99

site_id	IC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 S 149

Chain	Residue
B	ARG102
S	SER100
S	GLN101
S	ARG102

site_id	IC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA S 150

Chain	Residue
S	THR79
S	HOH232
U	HOH1368

site_id	IC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO S 151

Chain	Residue
S	ARG68
S	SER69
S	GLY70

site_id	JC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 T 148

Chain	Residue
S	LYS119
T	LYS119
U	LYS119

site_id	JC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA T 149

Chain	Residue
T	GLY24
T	GLY30

site_id	JC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA T 150

Chain	Residue
S	HOH155
T	ARG64
T	ILE65
T	HOH161

site_id	JC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL T 151

Chain	Residue
T	GLY70
T	LYS74

site_id	JC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO T 152

Chain	Residue
T	ARG68
T	SER69
T	GLN114
U	VAL83
U	ASP85
U	GOL151

site_id	JC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO T 153

Chain	Residue
S	SER69
T	VAL83
T	VAL84
T	ASP85
T	TYR88
T	EDO154

site_id	JC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO T 154

Chain	Residue
T	ILE65
T	GLY80
T	ALA81
T	GLY82
T	LYS93
T	VAL95
T	EDO153

site_id	JC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 U 148

Chain	Residue
U	SER100
U	GLN101
U	ARG102
U	EDO150

site_id	JC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL U 149

Chain	Residue
U	ASP130

site_id	KC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO U 150

Chain	Residue
S	GLN46
U	VAL73
U	LYS74
U	SER100
U	ARG102
U	SO4148

site_id	KC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL U 151

Chain	Residue
T	SER69
T	EDO152
U	VAL83
U	ASP85
U	TYR88
U	HOH230

site_id	KC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 V 148

Chain	Residue
V	GLN78
V	PHE97
V	HIS99
W	GLN78
W	PHE97
W	HIS99
X	GLN78
X	PHE97
X	HIS99

site_id	KC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 V 149

Chain	Residue
D	ASN75
D	ARG102
V	SER100
V	GLN101
V	ARG102

site_id	KC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 V 150

Chain	Residue
V	LYS119
V	HOH2221
W	LYS119
X	LYS119

site_id	KC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA V 151

Chain	Residue
V	ASN75
V	ASN98
V	SER100
V	ARG102
V	PHE104

site_id	KC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO V 152

Chain	Residue
V	VAL83
V	ASP85
V	TYR88
V	EDO153
V	HOH1029
X	SER69

site_id	KC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO V 153

Chain	Residue
V	TYR88
V	GLU91
V	VAL92
V	LYS93
V	EDO152
V	HOH1029

site_id	KC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA V 154

Chain	Residue
V	VAL57
V	ARG86

site_id	LC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL V 155

Chain	Residue
V	ARG68
V	GLY70

site_id	LC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO V 156

Chain	Residue
V	PRO67
V	ARG68
V	LEU71
V	ALA72
V	ILE77
V	VAL112
V	ALA113

site_id	LC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 W 148

Chain	Residue
W	SER100
W	GLN101
W	ARG102

site_id	LC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 W 149

Chain	Residue
W	ARG68
W	SER69
W	GLY70
W	HOH564
W	HOH1876

site_id	LC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO W 150

Chain	Residue
V	SER69
W	VAL83
W	ASP85
W	TYR88

site_id	LC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG X 148

Chain	Residue
W	SER69
X	VAL83
X	ASP85
X	ASP87
X	TYR88

site_id	LC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG X 149

Chain	Residue
X	ALA16
X	SER17
X	ALA18
X	LYS108
X	HOH157

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21548881","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3F4F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
A	ASP85
A	ASP87

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
J	ASP85
J	ASP87

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
K	ASP85
K	ASP87

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
L	ASP85
L	ASP87

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
M	ASP85
M	ASP87

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
N	ASP85
N	ASP87

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
O	ASP85
O	ASP87

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
P	ASP85
P	ASP87

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
Q	ASP85
Q	ASP87

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
R	ASP85
R	ASP87

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
S	ASP85
S	ASP87

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
B	ASP85
B	ASP87

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
T	ASP85
T	ASP87

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
U	ASP85
U	ASP87

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
V	ASP85
V	ASP87

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
W	ASP85
W	ASP87

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
X	ASP85
X	ASP87

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
C	ASP85
C	ASP87

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
D	ASP85
D	ASP87

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
E	ASP85
E	ASP87

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
F	ASP85
F	ASP87

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
G	ASP85
G	ASP87

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
H	ASP85
H	ASP87

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
I	ASP85
I	ASP87

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)