Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0009409 | biological_process | response to cold |
| A | 0009414 | biological_process | response to water deprivation |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0009651 | biological_process | response to salt stress |
| A | 0016229 | molecular_function | steroid dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAP A 401 |
| Chain | Residue |
| A | GLY22 |
| A | TYR202 |
| A | SER203 |
| A | PRO204 |
| A | LEU205 |
| A | GLY206 |
| A | SER207 |
| A | GLN208 |
| A | ARG214 |
| A | ALA235 |
| A | LEU250 |
| A | THR23 |
| A | PRO251 |
| A | LYS252 |
| A | SER253 |
| A | SER254 |
| A | ARG258 |
| A | GLU261 |
| A | ASN262 |
| A | ACT501 |
| A | HOH637 |
| A | HOH836 |
| A | TYR24 |
| A | HOH839 |
| A | HOH972 |
| A | HOH993 |
| A | HOH1002 |
| A | ASP43 |
| A | TYR48 |
| A | HIS110 |
| A | SER154 |
| A | ASN155 |
| A | GLN176 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 501 |
| Chain | Residue |
| A | TYR24 |
| A | TYR48 |
| A | HIS110 |
| A | NAP401 |
| A | HOH692 |
| A | HOH951 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 502 |
| Chain | Residue |
| A | PRO17 |
| A | CYS18 |
| A | VAL19 |
| A | ARG40 |
| A | HIS41 |
| A | HOH787 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 503 |
| Chain | Residue |
| A | GLN185 |
| A | GLY187 |
| A | LEU188 |
| A | GLU310 |
| A | HOH652 |
| A | HOH710 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 504 |
| Chain | Residue |
| A | THR123 |
| A | PRO124 |
| A | THR290 |
| A | GLU291 |
| A | ALA293 |
| A | HIS294 |
| A | HOH747 |
| A | HOH997 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 505 |
| Chain | Residue |
| A | LYS15 |
| A | LEU72 |
| A | PHE73 |
| A | HOH633 |
| A | HOH739 |
| A | HOH926 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 506 |
| Chain | Residue |
| A | ILE35 |
| A | LYS36 |
| A | ILE37 |
| A | ILE37 |
| A | GLY38 |
| A | ARG40 |
| A | PHE66 |
| A | HOH734 |
| A | HOH768 |
| A | HOH948 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 507 |
| Chain | Residue |
| A | ALA141 |
| A | LYS216 |
| A | EDO508 |
| A | HOH845 |
| A | HOH920 |
| A | HOH953 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 508 |
| Chain | Residue |
| A | GLU140 |
| A | ALA141 |
| A | ASP144 |
| A | ARG169 |
| A | LYS216 |
| A | EDO507 |
| A | HOH676 |
| A | HOH766 |
| A | HOH958 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 509 |
| Chain | Residue |
| A | GLU9 |
| A | ASN11 |
| A | LYS52 |
| A | GLY196 |
| A | HOH703 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 510 |
| Chain | Residue |
| A | HOH974 |
| A | GLU125 |
| A | GLU284 |
| A | ARG288 |
| A | HOH905 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 511 |
| Chain | Residue |
| A | LEU127 |
| A | HIS297 |
| A | PHE299 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 512 |
| Chain | Residue |
| A | GLN184 |
| A | GLN186 |
| A | GLN283 |
| A | HOH621 |
| A | HOH765 |
| A | HOH813 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 513 |
| Chain | Residue |
| A | GLU291 |
| A | PHE292 |
| A | HOH692 |
| A | HOH723 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MealydsgkARAIGVSNF |
| Chain | Residue | Details |
| A | MET139-PHE156 | |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. LPKSSSgaRLkENlDV |
| Chain | Residue | Details |
| A | LEU250-VAL265 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAsiygnEkeIG |
| Chain | Residue | Details |
| A | GLY38-GLY55 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR48 | |
| Chain | Residue | Details |
| A | THR23 | |
| A | ASP43 | |
| A | HIS110 | |
| A | SER154 | |
| A | GLN176 | |
| A | SER203 | |
| A | LYS252 | |
| A | ARG258 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | TYR48 | |
| A | ASP43 | |
| A | HIS110 | |
| A | LYS77 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | TYR48 | |
| A | LYS77 | |
