Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3H32

Crystal structure of D-dimer from human fibrin complexed with Gly-His-Arg-Pro-Tyr-amide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005577	cellular_component	fibrinogen complex
A	0007596	biological_process	blood coagulation
A	0030168	biological_process	platelet activation
A	0051258	biological_process	protein polymerization
B	0002250	biological_process	adaptive immune response
B	0005102	molecular_function	signaling receptor binding
B	0005198	molecular_function	structural molecule activity
B	0005201	molecular_function	extracellular matrix structural constituent
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005577	cellular_component	fibrinogen complex
B	0005615	cellular_component	extracellular space
B	0005783	cellular_component	endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0005938	cellular_component	cell cortex
B	0007160	biological_process	cell-matrix adhesion
B	0007596	biological_process	blood coagulation
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0030168	biological_process	platelet activation
B	0031091	cellular_component	platelet alpha granule
B	0031093	cellular_component	platelet alpha granule lumen
B	0031639	biological_process	plasminogen activation
B	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
B	0042730	biological_process	fibrinolysis
B	0043152	biological_process	induction of bacterial agglutination
B	0044320	biological_process	cellular response to leptin stimulus
B	0045087	biological_process	innate immune response
B	0045202	cellular_component	synapse
B	0045907	biological_process	positive regulation of vasoconstriction
B	0045921	biological_process	positive regulation of exocytosis
B	0050714	biological_process	positive regulation of protein secretion
B	0050839	molecular_function	cell adhesion molecule binding
B	0051087	molecular_function	protein-folding chaperone binding
B	0051258	biological_process	protein polymerization
B	0051592	biological_process	response to calcium ion
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0065003	biological_process	protein-containing complex assembly
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0070527	biological_process	platelet aggregation
B	0071347	biological_process	cellular response to interleukin-1
B	0072378	biological_process	blood coagulation, fibrin clot formation
B	0072562	cellular_component	blood microparticle
B	0090277	biological_process	positive regulation of peptide hormone secretion
B	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B	1903561	cellular_component	extracellular vesicle
B	2000352	biological_process	negative regulation of endothelial cell apoptotic process
C	0005102	molecular_function	signaling receptor binding
C	0005577	cellular_component	fibrinogen complex
C	0007596	biological_process	blood coagulation
C	0030168	biological_process	platelet activation
C	0051258	biological_process	protein polymerization
D	0005102	molecular_function	signaling receptor binding
D	0005577	cellular_component	fibrinogen complex
D	0007596	biological_process	blood coagulation
D	0030168	biological_process	platelet activation
D	0051258	biological_process	protein polymerization
E	0002250	biological_process	adaptive immune response
E	0005102	molecular_function	signaling receptor binding
E	0005198	molecular_function	structural molecule activity
E	0005201	molecular_function	extracellular matrix structural constituent
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005577	cellular_component	fibrinogen complex
E	0005615	cellular_component	extracellular space
E	0005783	cellular_component	endoplasmic reticulum
E	0005886	cellular_component	plasma membrane
E	0005938	cellular_component	cell cortex
E	0007160	biological_process	cell-matrix adhesion
E	0007596	biological_process	blood coagulation
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0030168	biological_process	platelet activation
E	0031091	cellular_component	platelet alpha granule
E	0031093	cellular_component	platelet alpha granule lumen
E	0031639	biological_process	plasminogen activation
E	0034116	biological_process	positive regulation of heterotypic cell-cell adhesion
E	0042730	biological_process	fibrinolysis
E	0043152	biological_process	induction of bacterial agglutination
E	0044320	biological_process	cellular response to leptin stimulus
E	0045087	biological_process	innate immune response
E	0045202	cellular_component	synapse
E	0045907	biological_process	positive regulation of vasoconstriction
E	0045921	biological_process	positive regulation of exocytosis
E	0050714	biological_process	positive regulation of protein secretion
E	0050839	molecular_function	cell adhesion molecule binding
E	0051087	molecular_function	protein-folding chaperone binding
E	0051258	biological_process	protein polymerization
E	0051592	biological_process	response to calcium ion
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0065003	biological_process	protein-containing complex assembly
E	0070062	cellular_component	extracellular exosome
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0070527	biological_process	platelet aggregation
E	0071347	biological_process	cellular response to interleukin-1
E	0072378	biological_process	blood coagulation, fibrin clot formation
E	0072562	cellular_component	blood microparticle
E	0090277	biological_process	positive regulation of peptide hormone secretion
E	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
E	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
E	1903561	cellular_component	extracellular vesicle
E	2000352	biological_process	negative regulation of endothelial cell apoptotic process
F	0005102	molecular_function	signaling receptor binding
F	0005577	cellular_component	fibrinogen complex
F	0007596	biological_process	blood coagulation
F	0030168	biological_process	platelet activation
F	0051258	biological_process	protein polymerization

Functional Information from PROSITE/UniProt

site_id	PS00514
Number of Residues	13
Details	FIBRINOGEN_C_1 Fibrinogen C-terminal domain signature. WWMnkChaGhlNG

Chain	Residue	Details
C	TRP334-GLY346
B	TRP402-GLY414

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:10074346, ECO:0000269\|PubMed:19296670, ECO:0000269\|PubMed:9016719, ECO:0000269\|PubMed:9207064, ECO:0000269\|PubMed:9333233, ECO:0000269\|PubMed:9628725, ECO:0007744\|PDB:1FID

Chain	Residue	Details
C	ASP318
C	ASP320
C	PHE322
C	GLY324
F	ASP318
F	ASP320
F	PHE322
F	GLY324

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; in variant Asahi

Chain	Residue	Details
C	ASN308
F	ASN308
E	LYS122
E	LYS133

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-432)

Chain	Residue	Details
C	GLN398
F	GLN398

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-424)

Chain	Residue	Details
B	GLN1
C	LYS406
F	LYS406

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10074346, ECO:0000269\|PubMed:16263699, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:9628725, ECO:0000269\|Ref.11

Chain	Residue	Details
B	ASN364
E	ASN364

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER31
D	SER31

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039

Chain	Residue	Details
A	SER37
D	SER37

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)