3H2X
Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 900 |
| Chain | Residue |
| A | CYS227 |
| A | HOH929 |
| A | SER228 |
| A | ALA229 |
| A | GLY230 |
| A | CYS231 |
| A | GLY232 |
| A | ARG233 |
| A | THR234 |
| A | GLN274 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 901 |
| Chain | Residue |
| A | MET130 |
| A | GLU131 |
| A | TYR132 |
| A | HIS189 |
| A | LYS191 |
| A | HOH321 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 902 |
| Chain | Residue |
| A | VAL48 |
| A | LYS51 |
| A | LYS53 |
| A | ASN54 |
| A | SER82 |
| A | SER83 |
| A | HOH931 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 903 |
| Chain | Residue |
| A | GLU131 |
| A | TYR132 |
| A | LYS137 |
| A | HOH314 |
| A | HOH923 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 904 |
| Chain | Residue |
| A | ARG233 |
| A | GLN278 |
| A | HOH338 |
| A | HOH987 |
| A | HOH1107 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCsaGcgRTG |
| Chain | Residue | Details |
| A | ILE225-GLY235 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 265 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2009","submissionDatabase":"PDB data bank","title":"Lyp/PTPN22 phosphatase domain: substrate recognition and specificity for Src family kinases.","authors":["Seidel R.D.","Love J.","Piserchio A.","Cowburn D."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCD","evidences":[{"source":"PubMed","id":"18056643","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | HIS226 | |
| A | THR234 | |
| A | GLU133 | |
| A | ASP195 | |
| A | ARG233 | |
| A | CYS227 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ytw |
| Chain | Residue | Details |
| A | ASP195 | |
| A | THR234 | |
| A | ARG233 | |
| A | CYS227 |
