Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3G33

Crystal structure of CDK4/cyclin D3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0000166	molecular_function	nucleotide binding
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000785	cellular_component	chromatin
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005923	cellular_component	bicellular tight junction
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009410	biological_process	response to xenobiotic stimulus
A	0010468	biological_process	regulation of gene expression
A	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
A	0016301	molecular_function	kinase activity
A	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
A	0016740	molecular_function	transferase activity
A	0030332	molecular_function	cyclin binding
A	0031965	cellular_component	nuclear membrane
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0051301	biological_process	cell division
A	0051726	biological_process	regulation of cell cycle
A	0060260	biological_process	regulation of transcription initiation by RNA polymerase II
A	0097128	cellular_component	cyclin D1-CDK4 complex
A	0097129	cellular_component	cyclin D2-CDK4 complex
A	0097130	cellular_component	cyclin D3-CDK4 complex
A	0106310	molecular_function	protein serine kinase activity
B	0000082	biological_process	G1/S transition of mitotic cell cycle
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005815	cellular_component	microtubule organizing center
B	0005829	cellular_component	cytosol
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0019901	molecular_function	protein kinase binding
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0051301	biological_process	cell division
B	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
B	0097130	cellular_component	cyclin D3-CDK4 complex
B	0097133	cellular_component	cyclin D3-CDK6 complex
B	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000166	molecular_function	nucleotide binding
C	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
C	0000785	cellular_component	chromatin
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005667	cellular_component	transcription regulator complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005923	cellular_component	bicellular tight junction
C	0006468	biological_process	protein phosphorylation
C	0007165	biological_process	signal transduction
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009410	biological_process	response to xenobiotic stimulus
C	0010468	biological_process	regulation of gene expression
C	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
C	0016301	molecular_function	kinase activity
C	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
C	0016740	molecular_function	transferase activity
C	0030332	molecular_function	cyclin binding
C	0031965	cellular_component	nuclear membrane
C	0048146	biological_process	positive regulation of fibroblast proliferation
C	0051301	biological_process	cell division
C	0051726	biological_process	regulation of cell cycle
C	0060260	biological_process	regulation of transcription initiation by RNA polymerase II
C	0097128	cellular_component	cyclin D1-CDK4 complex
C	0097129	cellular_component	cyclin D2-CDK4 complex
C	0097130	cellular_component	cyclin D3-CDK4 complex
C	0106310	molecular_function	protein serine kinase activity
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
D	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005815	cellular_component	microtubule organizing center
D	0005829	cellular_component	cytosol
D	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
D	0019901	molecular_function	protein kinase binding
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0051301	biological_process	cell division
D	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
D	0097130	cellular_component	cyclin D3-CDK4 complex
D	0097133	cellular_component	cyclin D3-CDK6 complex
D	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGVGAYGTVYkArdphsghf..........VALK

Chain	Residue	Details
A	ILE17-LYS40

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV

Chain	Residue	Details
A	ILE141-VAL153

site_id	PS00292
Number of Residues	32
Details	CYCLINS Cyclins signature. RkmLayWMlevceeqrCeeevFplAMnYLDRY

Chain	Residue	Details
B	ARG57-TYR88

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	578
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"Required for binding D-type cyclins"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16782892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19237555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19237565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19487459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	250
Details	Domain: {"description":"Cyclin N-terminal"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	GLU149

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP145
C	GLU149

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	LYS147

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP145
C	LYS147

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	THR182
A	LYS147

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP145
C	THR182
C	LYS147

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	LYS147
A	ASN150

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP145
C	LYS147
C	ASN150

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)