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3G33

Crystal structure of CDK4/cyclin D3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000166molecular_functionnucleotide binding
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000785cellular_componentchromatin
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005923cellular_componentbicellular tight junction
A0006468biological_processprotein phosphorylation
A0007165biological_processsignal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010468biological_processregulation of gene expression
A0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
A0016740molecular_functiontransferase activity
A0030332molecular_functioncyclin binding
A0031965cellular_componentnuclear membrane
A0048146biological_processpositive regulation of fibroblast proliferation
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0060260biological_processregulation of transcription initiation by RNA polymerase II
A0061469biological_processregulation of type B pancreatic cell proliferation
A0071222biological_processcellular response to lipopolysaccharide
A0071353biological_processcellular response to interleukin-4
A0097128cellular_componentcyclin D1-CDK4 complex
A0097129cellular_componentcyclin D2-CDK4 complex
A0097130cellular_componentcyclin D3-CDK4 complex
A0106310molecular_functionprotein serine kinase activity
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
A1904637biological_processcellular response to ionomycin
B0000082biological_processG1/S transition of mitotic cell cycle
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005815cellular_componentmicrotubule organizing center
B0005829cellular_componentcytosol
B0007165biological_processsignal transduction
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0019901molecular_functionprotein kinase binding
B0042098biological_processT cell proliferation
B0042127biological_processregulation of cell population proliferation
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
B0097130cellular_componentcyclin D3-CDK4 complex
B0097133cellular_componentcyclin D3-CDK6 complex
B1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
C0000082biological_processG1/S transition of mitotic cell cycle
C0000166molecular_functionnucleotide binding
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0000785cellular_componentchromatin
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005667cellular_componenttranscription regulator complex
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005923cellular_componentbicellular tight junction
C0006468biological_processprotein phosphorylation
C0007165biological_processsignal transduction
C0008284biological_processpositive regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0010389biological_processregulation of G2/M transition of mitotic cell cycle
C0010468biological_processregulation of gene expression
C0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
C0016740molecular_functiontransferase activity
C0030332molecular_functioncyclin binding
C0031965cellular_componentnuclear membrane
C0048146biological_processpositive regulation of fibroblast proliferation
C0051301biological_processcell division
C0051726biological_processregulation of cell cycle
C0060260biological_processregulation of transcription initiation by RNA polymerase II
C0061469biological_processregulation of type B pancreatic cell proliferation
C0071222biological_processcellular response to lipopolysaccharide
C0071353biological_processcellular response to interleukin-4
C0097128cellular_componentcyclin D1-CDK4 complex
C0097129cellular_componentcyclin D2-CDK4 complex
C0097130cellular_componentcyclin D3-CDK4 complex
C0106310molecular_functionprotein serine kinase activity
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C1904637biological_processcellular response to ionomycin
D0000082biological_processG1/S transition of mitotic cell cycle
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
D0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005815cellular_componentmicrotubule organizing center
D0005829cellular_componentcytosol
D0007165biological_processsignal transduction
D0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
D0019901molecular_functionprotein kinase binding
D0042098biological_processT cell proliferation
D0042127biological_processregulation of cell population proliferation
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0051301biological_processcell division
D0051726biological_processregulation of cell cycle
D0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
D0097130cellular_componentcyclin D3-CDK4 complex
D0097133cellular_componentcyclin D3-CDK6 complex
D1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGVGAYGTVYkArdphsghf..........VALK
ChainResidueDetails
AILE17-LYS40

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV
ChainResidueDetails
AILE141-VAL153

site_idPS00292
Number of Residues32
DetailsCYCLINS Cyclins signature. RkmLayWMlevceeqrCeeevFplAMnYLDRY
ChainResidueDetails
BARG57-TYR88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P30282
ChainResidueDetails
BSER264
DSER264

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
BSER279
DSER279
CILE17
CLYS40

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P24385
ChainResidueDetails
BTHR283
DTHR283

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:19237555, ECO:0000269|PubMed:19237565, ECO:0000269|PubMed:19487459, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATHR177
CTHR177

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP145
AGLU149

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP145
CGLU149

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP145
ALYS147

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP145
CLYS147

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP145
ATHR182
ALYS147

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP145
CTHR182
CLYS147

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP145
ALYS147
AASN150

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP145
CLYS147
CASN150

237992

PDB entries from 2025-06-25

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