3FVK
Crystal structure of the human glutamate receptor, GluR5, ligand-binding core in complex with 8-deoxy-neodysiherbaine A in space group P1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 3968 |
| Chain | Residue |
| A | HOH4 |
| A | HOH22 |
| A | HOH54 |
| A | HOH212 |
| A | THR505 |
| A | THR677 |
| A | PHE678 |
| A | LYS747 |
| B | HOH41 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 3971 |
| Chain | Residue |
| A | HOH196 |
| A | HOH198 |
| A | PRO517 |
| A | SER746 |
| A | GLY748 |
| B | THR520 |
| B | GLN771 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 3974 |
| Chain | Residue |
| A | ILE420 |
| A | THR422 |
| A | LYS467 |
| A | LEU468 |
| A | VAL469 |
| A | PRO470 |
| A | GLU489 |
| A | ARG494 |
| A | ALA495 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 3975 |
| Chain | Residue |
| A | HOH301 |
| A | ASP657 |
| A | THR686 |
| A | TYR687 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 3976 |
| Chain | Residue |
| A | HOH224 |
| A | ASP672 |
| A | LYS680 |
| A | TRP691 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 8DX A 1 |
| Chain | Residue |
| A | HOH40 |
| A | GLU426 |
| A | TYR474 |
| A | PRO501 |
| A | LEU502 |
| A | THR503 |
| A | ARG508 |
| A | VAL670 |
| A | GLY673 |
| A | SER674 |
| A | THR675 |
| A | SER706 |
| A | MET722 |
| A | GLU723 |
| A | SER726 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 791 |
| Chain | Residue |
| A | HOH68 |
| A | HOH120 |
| A | HOH345 |
| A | ARG444 |
| A | LYS467 |
| A | LEU468 |
| B | ARG704 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 3969 |
| Chain | Residue |
| A | HOH198 |
| A | THR520 |
| A | GLN771 |
| B | HOH195 |
| B | PRO517 |
| B | SER746 |
| B | GLY748 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 3970 |
| Chain | Residue |
| A | HOH12 |
| A | HOH39 |
| B | HOH16 |
| B | HOH242 |
| B | THR505 |
| B | SER674 |
| B | THR677 |
| B | PHE678 |
| B | LYS747 |
| B | HOH792 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 3972 |
| Chain | Residue |
| B | HOH147 |
| B | HOH243 |
| B | HOH287 |
| B | LYS454 |
| B | TYR464 |
| B | ALA660 |
| B | LYS661 |
| B | THR663 |
| B | LYS689 |
| B | PHE693 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 8DX B 2 |
| Chain | Residue |
| B | HOH13 |
| B | GLU426 |
| B | TYR474 |
| B | PRO501 |
| B | LEU502 |
| B | THR503 |
| B | ARG508 |
| B | VAL670 |
| B | GLY673 |
| B | SER674 |
| B | THR675 |
| B | SER706 |
| B | MET722 |
| B | GLU723 |
| B | SER726 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 791 |
| Chain | Residue |
| B | ASN787 |
| B | ARG417 |
| B | TYR759 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3 |
| Chain | Residue |
| B | HOH218 |
| B | ARG444 |
| B | VAL466 |
| B | LYS467 |
| B | LEU468 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21893069","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ZNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
